Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome
This study aimed to investigate the effects of administration of xanthan gum-based fluid thickener on the regulation of postprandial blood glucose level, gene expression in the gastrointestinal tract, and gut microbiome. Six-week-old Sprague-Dawley rats were divided into two groups: with (Th group)...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2022-12-01
|
Series: | Journal of Functional Foods |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622003917 |
_version_ | 1811187858742968320 |
---|---|
author | Yuki Nagasawa Sayaka Katagiri Kazuharu Nakagawa Tomomitsu Hirota Kanako Yoshimi Aritoshi Uchida Masahiro Hatasa Keiji Komatsu Takahiko Shiba Yujin Ohsugi Naofumi Uesaka Takanori Iwata Haruka Tohara |
author_facet | Yuki Nagasawa Sayaka Katagiri Kazuharu Nakagawa Tomomitsu Hirota Kanako Yoshimi Aritoshi Uchida Masahiro Hatasa Keiji Komatsu Takahiko Shiba Yujin Ohsugi Naofumi Uesaka Takanori Iwata Haruka Tohara |
author_sort | Yuki Nagasawa |
collection | DOAJ |
description | This study aimed to investigate the effects of administration of xanthan gum-based fluid thickener on the regulation of postprandial blood glucose level, gene expression in the gastrointestinal tract, and gut microbiome. Six-week-old Sprague-Dawley rats were divided into two groups: with (Th group) and without (Co group) the administration of a xanthan gum-based fluid thickener for 5 wks. Blood glucose levels at 60 and 90 min after glucose administration were substantially decreased in the Th group. Glp1 and Glp1r expression in the ileum was significantly upregulated after continuous administration of thickener. RNA-seq analysis revealed that the cholesterol homeostasis, fatty acid metabolism, and glycolysis gene sets were enriched in the ileum of Th group. Microbial composition in the gut was altered after administrating the fluid thickener, and relative abundance in Erysipelotrichales and Christensenellaceae showed positive correlation with Glp1 and Glp1r expression in the ileum. Xanthan gum-based fluid thickener may ameliorate glucose/lipid metabolism. |
first_indexed | 2024-04-11T14:10:42Z |
format | Article |
id | doaj.art-caad1f1644744c92b55f340a13be8e26 |
institution | Directory Open Access Journal |
issn | 1756-4646 |
language | English |
last_indexed | 2024-04-11T14:10:42Z |
publishDate | 2022-12-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of Functional Foods |
spelling | doaj.art-caad1f1644744c92b55f340a13be8e262022-12-22T04:19:45ZengElsevierJournal of Functional Foods1756-46462022-12-0199105321Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiomeYuki Nagasawa0Sayaka Katagiri1Kazuharu Nakagawa2Tomomitsu Hirota3Kanako Yoshimi4Aritoshi Uchida5Masahiro Hatasa6Keiji Komatsu7Takahiko Shiba8Yujin Ohsugi9Naofumi Uesaka10Takanori Iwata11Haruka Tohara12Dysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; Corresponding authors.Dysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; Corresponding authors.Division of Molecular Genetics, Research Center for Medical Sciences, The Jikei University School of Medicine, JapanDysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Lifetime Oral Health Care Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Neurophysiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanThis study aimed to investigate the effects of administration of xanthan gum-based fluid thickener on the regulation of postprandial blood glucose level, gene expression in the gastrointestinal tract, and gut microbiome. Six-week-old Sprague-Dawley rats were divided into two groups: with (Th group) and without (Co group) the administration of a xanthan gum-based fluid thickener for 5 wks. Blood glucose levels at 60 and 90 min after glucose administration were substantially decreased in the Th group. Glp1 and Glp1r expression in the ileum was significantly upregulated after continuous administration of thickener. RNA-seq analysis revealed that the cholesterol homeostasis, fatty acid metabolism, and glycolysis gene sets were enriched in the ileum of Th group. Microbial composition in the gut was altered after administrating the fluid thickener, and relative abundance in Erysipelotrichales and Christensenellaceae showed positive correlation with Glp1 and Glp1r expression in the ileum. Xanthan gum-based fluid thickener may ameliorate glucose/lipid metabolism.http://www.sciencedirect.com/science/article/pii/S1756464622003917NutrientsXanthan gumFluid thickenerPostprandial blood glucoseGut microbiome |
spellingShingle | Yuki Nagasawa Sayaka Katagiri Kazuharu Nakagawa Tomomitsu Hirota Kanako Yoshimi Aritoshi Uchida Masahiro Hatasa Keiji Komatsu Takahiko Shiba Yujin Ohsugi Naofumi Uesaka Takanori Iwata Haruka Tohara Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome Journal of Functional Foods Nutrients Xanthan gum Fluid thickener Postprandial blood glucose Gut microbiome |
title | Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome |
title_full | Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome |
title_fullStr | Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome |
title_full_unstemmed | Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome |
title_short | Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome |
title_sort | xanthan gum based fluid thickener decreases postprandial blood glucose associated with increase of glp1 and glp1r expression in ileum and alteration of gut microbiome |
topic | Nutrients Xanthan gum Fluid thickener Postprandial blood glucose Gut microbiome |
url | http://www.sciencedirect.com/science/article/pii/S1756464622003917 |
work_keys_str_mv | AT yukinagasawa xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT sayakakatagiri xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT kazuharunakagawa xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT tomomitsuhirota xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT kanakoyoshimi xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT aritoshiuchida xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT masahirohatasa xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT keijikomatsu xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT takahikoshiba xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT yujinohsugi xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT naofumiuesaka xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT takanoriiwata xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome AT harukatohara xanthangumbasedfluidthickenerdecreasespostprandialbloodglucoseassociatedwithincreaseofglp1andglp1rexpressioninileumandalterationofgutmicrobiome |