Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome

This study aimed to investigate the effects of administration of xanthan gum-based fluid thickener on the regulation of postprandial blood glucose level, gene expression in the gastrointestinal tract, and gut microbiome. Six-week-old Sprague-Dawley rats were divided into two groups: with (Th group)...

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Main Authors: Yuki Nagasawa, Sayaka Katagiri, Kazuharu Nakagawa, Tomomitsu Hirota, Kanako Yoshimi, Aritoshi Uchida, Masahiro Hatasa, Keiji Komatsu, Takahiko Shiba, Yujin Ohsugi, Naofumi Uesaka, Takanori Iwata, Haruka Tohara
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Functional Foods
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Online Access:http://www.sciencedirect.com/science/article/pii/S1756464622003917
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author Yuki Nagasawa
Sayaka Katagiri
Kazuharu Nakagawa
Tomomitsu Hirota
Kanako Yoshimi
Aritoshi Uchida
Masahiro Hatasa
Keiji Komatsu
Takahiko Shiba
Yujin Ohsugi
Naofumi Uesaka
Takanori Iwata
Haruka Tohara
author_facet Yuki Nagasawa
Sayaka Katagiri
Kazuharu Nakagawa
Tomomitsu Hirota
Kanako Yoshimi
Aritoshi Uchida
Masahiro Hatasa
Keiji Komatsu
Takahiko Shiba
Yujin Ohsugi
Naofumi Uesaka
Takanori Iwata
Haruka Tohara
author_sort Yuki Nagasawa
collection DOAJ
description This study aimed to investigate the effects of administration of xanthan gum-based fluid thickener on the regulation of postprandial blood glucose level, gene expression in the gastrointestinal tract, and gut microbiome. Six-week-old Sprague-Dawley rats were divided into two groups: with (Th group) and without (Co group) the administration of a xanthan gum-based fluid thickener for 5 wks. Blood glucose levels at 60 and 90 min after glucose administration were substantially decreased in the Th group. Glp1 and Glp1r expression in the ileum was significantly upregulated after continuous administration of thickener. RNA-seq analysis revealed that the cholesterol homeostasis, fatty acid metabolism, and glycolysis gene sets were enriched in the ileum of Th group. Microbial composition in the gut was altered after administrating the fluid thickener, and relative abundance in Erysipelotrichales and Christensenellaceae showed positive correlation with Glp1 and Glp1r expression in the ileum. Xanthan gum-based fluid thickener may ameliorate glucose/lipid metabolism.
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spelling doaj.art-caad1f1644744c92b55f340a13be8e262022-12-22T04:19:45ZengElsevierJournal of Functional Foods1756-46462022-12-0199105321Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiomeYuki Nagasawa0Sayaka Katagiri1Kazuharu Nakagawa2Tomomitsu Hirota3Kanako Yoshimi4Aritoshi Uchida5Masahiro Hatasa6Keiji Komatsu7Takahiko Shiba8Yujin Ohsugi9Naofumi Uesaka10Takanori Iwata11Haruka Tohara12Dysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; Corresponding authors.Dysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; Corresponding authors.Division of Molecular Genetics, Research Center for Medical Sciences, The Jikei University School of Medicine, JapanDysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Lifetime Oral Health Care Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Neurophysiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanDysphagia Rehabilitation, Department of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, JapanThis study aimed to investigate the effects of administration of xanthan gum-based fluid thickener on the regulation of postprandial blood glucose level, gene expression in the gastrointestinal tract, and gut microbiome. Six-week-old Sprague-Dawley rats were divided into two groups: with (Th group) and without (Co group) the administration of a xanthan gum-based fluid thickener for 5 wks. Blood glucose levels at 60 and 90 min after glucose administration were substantially decreased in the Th group. Glp1 and Glp1r expression in the ileum was significantly upregulated after continuous administration of thickener. RNA-seq analysis revealed that the cholesterol homeostasis, fatty acid metabolism, and glycolysis gene sets were enriched in the ileum of Th group. Microbial composition in the gut was altered after administrating the fluid thickener, and relative abundance in Erysipelotrichales and Christensenellaceae showed positive correlation with Glp1 and Glp1r expression in the ileum. Xanthan gum-based fluid thickener may ameliorate glucose/lipid metabolism.http://www.sciencedirect.com/science/article/pii/S1756464622003917NutrientsXanthan gumFluid thickenerPostprandial blood glucoseGut microbiome
spellingShingle Yuki Nagasawa
Sayaka Katagiri
Kazuharu Nakagawa
Tomomitsu Hirota
Kanako Yoshimi
Aritoshi Uchida
Masahiro Hatasa
Keiji Komatsu
Takahiko Shiba
Yujin Ohsugi
Naofumi Uesaka
Takanori Iwata
Haruka Tohara
Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome
Journal of Functional Foods
Nutrients
Xanthan gum
Fluid thickener
Postprandial blood glucose
Gut microbiome
title Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome
title_full Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome
title_fullStr Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome
title_full_unstemmed Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome
title_short Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome
title_sort xanthan gum based fluid thickener decreases postprandial blood glucose associated with increase of glp1 and glp1r expression in ileum and alteration of gut microbiome
topic Nutrients
Xanthan gum
Fluid thickener
Postprandial blood glucose
Gut microbiome
url http://www.sciencedirect.com/science/article/pii/S1756464622003917
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