Assessment of Subclinical Cardiovascular Disease Risk by Measuring Carotid Intima Media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional Study
Introduction: Rheumatoid Arthritis (RA) is a chronic inflammatory disease that affects both synovial joints and extra-articular regions. Patients with RA have an increased risk of Cardiovascular Disease (CVD), leading to premature mortality. Aim: To assess subclinical atherosclerosis in RA patie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2024-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18925/67951_CE[Ra1]_F(SL)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
| _version_ | 1827385136001318912 |
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| author | Tamanna Singh Manaswi Chaubey Ranjan Bhattnagar Niharika Mayank Aditya Debuka |
| author_facet | Tamanna Singh Manaswi Chaubey Ranjan Bhattnagar Niharika Mayank Aditya Debuka |
| author_sort | Tamanna Singh |
| collection | DOAJ |
| description | Introduction: Rheumatoid Arthritis (RA) is a chronic inflammatory
disease that affects both synovial joints and extra-articular
regions. Patients with RA have an increased risk of Cardiovascular
Disease (CVD), leading to premature mortality.
Aim: To assess subclinical atherosclerosis in RA patients using
Carotid Intima Media Thickness (CIMT) and compare it with
age-matched healthy individuals.
Materials and Methods: This cross-sectional study included
50 RA patients and 50 healthy age- and sex-matched controls.
Ultrasound was used to measure CIMT, which serves as
an indicator of subclinical atherosclerosis. Framingham,
Atherosclerotic CVD (ASCVD) risk scores, and QRISK3 scores
were used to estimate the 10-year CVD risk. Student’s t-test
and Chi-square test were used to identify statistically significant
differences.
Results: RA patients had significantly higher mean CIMT values
compared to controls (p-value<0.001), indicating an increased
burden of atherosclerosis. While ASCVD scores were comparable,
Framingham scores were significantly lower (p-value=0.028),
and QRISK3 scores were significantly higher (p-value=0.007) in
RA patients. This suggests an underestimation of CVD risk by
Framingham and potentially better prediction by QRISK3.
Conclusion: The study highlights that RA patients have a
higher burden of atherosclerotic disease compared to healthy
adults of the same age when CIMT is used as a marker of
atherosclerosis. These findings indicate the need for early
CVD risk assessment and intervention in RA patients using
appropriate risk-scoring systems and tools. Further research
with larger sample sizes and longitudinal follow-up is warranted
to confirm these findings. |
| first_indexed | 2024-03-08T15:16:37Z |
| format | Article |
| id | doaj.art-caae33c8f8f949e49e97466c963f0928 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-08T15:16:37Z |
| publishDate | 2024-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-caae33c8f8f949e49e97466c963f09282024-01-10T12:14:23ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-01-011801353810.7860/JCDR/2024/67951.18925Assessment of Subclinical Cardiovascular Disease Risk by Measuring Carotid Intima Media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional StudyTamanna Singh0Manaswi Chaubey1Ranjan Bhattnagar2Niharika Mayank3Aditya Debuka4Junior Resident, Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Associate Professor, Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Associate Professor, Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Junior Resident, Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Junior Resident, Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Introduction: Rheumatoid Arthritis (RA) is a chronic inflammatory disease that affects both synovial joints and extra-articular regions. Patients with RA have an increased risk of Cardiovascular Disease (CVD), leading to premature mortality. Aim: To assess subclinical atherosclerosis in RA patients using Carotid Intima Media Thickness (CIMT) and compare it with age-matched healthy individuals. Materials and Methods: This cross-sectional study included 50 RA patients and 50 healthy age- and sex-matched controls. Ultrasound was used to measure CIMT, which serves as an indicator of subclinical atherosclerosis. Framingham, Atherosclerotic CVD (ASCVD) risk scores, and QRISK3 scores were used to estimate the 10-year CVD risk. Student’s t-test and Chi-square test were used to identify statistically significant differences. Results: RA patients had significantly higher mean CIMT values compared to controls (p-value<0.001), indicating an increased burden of atherosclerosis. While ASCVD scores were comparable, Framingham scores were significantly lower (p-value=0.028), and QRISK3 scores were significantly higher (p-value=0.007) in RA patients. This suggests an underestimation of CVD risk by Framingham and potentially better prediction by QRISK3. Conclusion: The study highlights that RA patients have a higher burden of atherosclerotic disease compared to healthy adults of the same age when CIMT is used as a marker of atherosclerosis. These findings indicate the need for early CVD risk assessment and intervention in RA patients using appropriate risk-scoring systems and tools. Further research with larger sample sizes and longitudinal follow-up is warranted to confirm these findings.https://www.jcdr.net/articles/PDF/18925/67951_CE[Ra1]_F(SL)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdfatherosclerosiscarotid ultrasoundinflammation |
| spellingShingle | Tamanna Singh Manaswi Chaubey Ranjan Bhattnagar Niharika Mayank Aditya Debuka Assessment of Subclinical Cardiovascular Disease Risk by Measuring Carotid Intima Media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional Study Journal of Clinical and Diagnostic Research atherosclerosis carotid ultrasound inflammation |
| title | Assessment of Subclinical Cardiovascular Disease Risk by Measuring Carotid Intima Media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional Study |
| title_full | Assessment of Subclinical Cardiovascular Disease Risk by Measuring Carotid Intima Media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional Study |
| title_fullStr | Assessment of Subclinical Cardiovascular Disease Risk by Measuring Carotid Intima Media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional Study |
| title_full_unstemmed | Assessment of Subclinical Cardiovascular Disease Risk by Measuring Carotid Intima Media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional Study |
| title_short | Assessment of Subclinical Cardiovascular Disease Risk by Measuring Carotid Intima Media Thickness in Rheumatoid Arthritis Patients: A Cross-sectional Study |
| title_sort | assessment of subclinical cardiovascular disease risk by measuring carotid intima media thickness in rheumatoid arthritis patients a cross sectional study |
| topic | atherosclerosis carotid ultrasound inflammation |
| url | https://www.jcdr.net/articles/PDF/18925/67951_CE[Ra1]_F(SL)_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
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