Leukemic conversion involving RAS mutations of type 1 CALR-mutated primary myelofibrosis in a patient treated for HCV cirrhosis: a case report

Leukemic conversion involving RAS mutations of type 1 CALR-mutated primary myelofibrosis in a patient treated for HCV cirrhosis: a case report

Somatic frameshift mutations in exon 9 of calreticulin (CALR) gene are recognized as disease drivers in primary myelofibrosis (PMF), one of the three classical Philadelphia-negative myeloproliferative neoplasms (MPNs). Type 1/type 1-like CALR mutations particularly confer a favorable prognostic and...

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Main Authors: Petruta Gurban, Cristina Mambet, Anca Botezatu, Laura G. Necula, Ana I. Neagu, Lilia Matei, Ioana M. Pitica, Saviana Nedeianu, Mihaela Chivu-Economescu, Coralia Bleotu, Marius Ataman, Gabriela Mocanu, Carmen Saguna, Anca G. Pavel, Danae Stambouli, Elise Sepulchre, Gabriela Anton, Carmen C. Diaconu, Stefan N. Constantinescu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Oncology
Subjects:
primary myelofibrosis (PMF)
hepatitis C virus (HCV) cirrhosis
type 1 calreticulin (CALR)
targeted next-generation sequencing (NGS)
NRAS
acquired uniparental disomy (aUPD)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1266996/full

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