Primary Sjögren’s syndrome related optic neuritis
<b>AIM:</b>To determine the clinical features, diagnosis and treatment of the primary Sjögren syndrome (SS) related optic neuritis.<b>METHODS:</b>The clinical data of 8 patients (12 eyes) with primary SS related optic neuritis were analyzed retrospectively.<b>RESULTS:&l...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2013-12-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874534/ |
| Summary: | <b>AIM:</b>To determine the clinical features, diagnosis and treatment of the primary Sjögren syndrome (SS) related optic neuritis.<b>METHODS:</b>The clinical data of 8 patients (12 eyes) with primary SS related optic neuritis were analyzed retrospectively.<b>RESULTS:</b> Eight of 128 consecutive patients with optic neuritis resulted from varied causes fulfilled the diagnostic criteria for the primary SS. They presented initially with the signs and symptoms of non-specific optic neuritis, and 5 patients presenting without dryness showed a chronic inflammation of submandibular gland or parotid gland, and lymphocyte infiltration was demonstrated by labial gland biopsy in 2 patients. There were serum positive titers for anti-Sjögren syndrome A (SSA) in 7 patients and anti-Sjögren syndrome B (SSB) in 8 patients. Anti-aquaporin-4 (AQP4) antibody was negative in all the 8 patients. Both glucocorticoids and immunosuppressive agent were administered, and visual acuity elevated in 8 eyes (66.7%), 3 patients (37.5%) recurred in the follow-up.<b>CONCLUSION:</b>Primary SS related optic neuritis is less common and easily misdiagnosed. The conventional therapies for optic neuritis could not control the recurrence. |
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| ISSN: | 2222-3959 2227-4898 |