ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population
Abstract Single‐nucleotide polymorphisms (SNP) of ATP2B1 gene are associated with essential hypertension but their association with resistant hypertension (RHT) remains unexplored. The authors examined the relationship between ATP2B1 SNPs and RHT by genotyping 12 SNPs in ATP2B1 gene of 1124 Japanese...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14785 |
| _version_ | 1827287617611235328 |
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| author | Yusuke Kobayashi Keisuke Yatsu Aiko Haruna Rina Kawano Moe Ozawa Tatsuya Haze Shiro Komiya Shota Suzuki Yuki Ohki Akira Fujiwara Sanae Saka Nobuhito Hirawa Yoshiyuki Toya Kouichi Tamura |
| author_facet | Yusuke Kobayashi Keisuke Yatsu Aiko Haruna Rina Kawano Moe Ozawa Tatsuya Haze Shiro Komiya Shota Suzuki Yuki Ohki Akira Fujiwara Sanae Saka Nobuhito Hirawa Yoshiyuki Toya Kouichi Tamura |
| author_sort | Yusuke Kobayashi |
| collection | DOAJ |
| description | Abstract Single‐nucleotide polymorphisms (SNP) of ATP2B1 gene are associated with essential hypertension but their association with resistant hypertension (RHT) remains unexplored. The authors examined the relationship between ATP2B1 SNPs and RHT by genotyping 12 SNPs in ATP2B1 gene of 1124 Japanese individuals with lifestyle‐related diseases. Patients with RHT had inadequate blood pressure (BP) control using three antihypertensive drugs or used ≥4 antihypertensive drugs. Patients with controlled hypertension had BP controlled using ≤3 antihypertensive drugs. The association between each SNP and RHT was analyzed by logistic regression. The final cohort had 888 (79.0%) and 43 (3.8%) patients with controlled hypertension and RHT, respectively. Compared with patients homozygous for the minor allele of each SNP in ATP2B1, a significantly higher number of patients carrying the major allele at 10 SNPs exhibited RHT (most significant at rs1401982: 5.8% vs. 0.8%, p = .014; least significant at rs11105378: 5.7% vs. 0.9%, p = .035; most nonsignificant at rs12817819: 5.1% vs. 10%, p = .413). After multivariate adjustment for age, sex, systolic BP, and other confounders, the association remained significant for rs2681472 and rs1401982 (OR: 7.60, p < .05 and OR: 7.62, p = .049, respectively). Additionally, rs2681472 and rs1401982 were in linkage disequilibrium with rs11105378. This study identified two ATP2B1 SNPs associated with RHT in the Japanese population. rs1401982 was most closely associated with RHT, and major allele carriers of rs1401982 required significantly more antihypertensive medications. Analysis of ATP2B1 SNPs in patients with hypertension can help in early prediction of RHT and identification of high‐risk patients who are more likely to require more antihypertensive medications. |
| first_indexed | 2024-04-24T11:14:20Z |
| format | Article |
| id | doaj.art-cab2df7edd994d4695a4088fb82f2d41 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-04-24T11:14:20Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-cab2df7edd994d4695a4088fb82f2d412024-04-11T11:01:33ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762024-04-0126435536210.1111/jch.14785ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese populationYusuke Kobayashi0Keisuke Yatsu1Aiko Haruna2Rina Kawano3Moe Ozawa4Tatsuya Haze5Shiro Komiya6Shota Suzuki7Yuki Ohki8Akira Fujiwara9Sanae Saka10Nobuhito Hirawa11Yoshiyuki Toya12Kouichi Tamura13Center for Novel and Exploratory Clinical Trials (Y‐NEXT) Yokohama City University Yokohama JapanMinna no Naika Clinic Ningyocho‐Suitengu Tokyo JapanDepartment of Nephrology and Hypertension Yokohama City University Medical Center Yokohama JapanDepartment of Nephrology and Hypertension Yokohama City University Medical Center Yokohama JapanDepartment of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama JapanCenter for Novel and Exploratory Clinical Trials (Y‐NEXT) Yokohama City University Yokohama JapanDepartment of Nephrology and Hypertension Saiseikai Yokohamashi Nanbu Hospital Yokohama JapanDepartment of Nephrology and Hypertension Yokohama City University Medical Center Yokohama JapanDepartment of Nephrology and Hypertension Yokohama City University Medical Center Yokohama JapanDepartment of Nephrology and Hypertension Yokohama City University Medical Center Yokohama JapanDepartment of Nephrology and Hypertension Saiseikai Yokohamashi Nanbu Hospital Yokohama JapanDepartment of Nephrology and Hypertension Yokohama City University Medical Center Yokohama JapanDepartment of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama JapanDepartment of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama JapanAbstract Single‐nucleotide polymorphisms (SNP) of ATP2B1 gene are associated with essential hypertension but their association with resistant hypertension (RHT) remains unexplored. The authors examined the relationship between ATP2B1 SNPs and RHT by genotyping 12 SNPs in ATP2B1 gene of 1124 Japanese individuals with lifestyle‐related diseases. Patients with RHT had inadequate blood pressure (BP) control using three antihypertensive drugs or used ≥4 antihypertensive drugs. Patients with controlled hypertension had BP controlled using ≤3 antihypertensive drugs. The association between each SNP and RHT was analyzed by logistic regression. The final cohort had 888 (79.0%) and 43 (3.8%) patients with controlled hypertension and RHT, respectively. Compared with patients homozygous for the minor allele of each SNP in ATP2B1, a significantly higher number of patients carrying the major allele at 10 SNPs exhibited RHT (most significant at rs1401982: 5.8% vs. 0.8%, p = .014; least significant at rs11105378: 5.7% vs. 0.9%, p = .035; most nonsignificant at rs12817819: 5.1% vs. 10%, p = .413). After multivariate adjustment for age, sex, systolic BP, and other confounders, the association remained significant for rs2681472 and rs1401982 (OR: 7.60, p < .05 and OR: 7.62, p = .049, respectively). Additionally, rs2681472 and rs1401982 were in linkage disequilibrium with rs11105378. This study identified two ATP2B1 SNPs associated with RHT in the Japanese population. rs1401982 was most closely associated with RHT, and major allele carriers of rs1401982 required significantly more antihypertensive medications. Analysis of ATP2B1 SNPs in patients with hypertension can help in early prediction of RHT and identification of high‐risk patients who are more likely to require more antihypertensive medications.https://doi.org/10.1111/jch.14785ATP2B1 gene polymorphismsblood pressuregenotypingJapaneseresistant hypertension |
| spellingShingle | Yusuke Kobayashi Keisuke Yatsu Aiko Haruna Rina Kawano Moe Ozawa Tatsuya Haze Shiro Komiya Shota Suzuki Yuki Ohki Akira Fujiwara Sanae Saka Nobuhito Hirawa Yoshiyuki Toya Kouichi Tamura ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population The Journal of Clinical Hypertension ATP2B1 gene polymorphisms blood pressure genotyping Japanese resistant hypertension |
| title | ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population |
| title_full | ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population |
| title_fullStr | ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population |
| title_full_unstemmed | ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population |
| title_short | ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population |
| title_sort | atp2b1 gene polymorphisms associated with resistant hypertension in the japanese population |
| topic | ATP2B1 gene polymorphisms blood pressure genotyping Japanese resistant hypertension |
| url | https://doi.org/10.1111/jch.14785 |
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