Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair

Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair

The earliest methods of genome editing, such as zinc-finger nucleases (ZFN) and transcription activator-like effector nucleases (TALENs), utilize customizable DNA-binding motifs to target the genome at specific loci. While these approaches provided sequence-specific gene-editing capacity, the labori...

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Dettagli Bibliografici
Autori principali:	Marlo K. Thompson, Robert W. Sobol, Aishwarya Prakash
Natura:	Articolo
Lingua:	English
Pubblicazione:	MDPI AG 2021-06-01
Serie:	Biology
Soggetti:	CRISPR gene editing base excision repair mismatch repair homologous recombination non-homologous end-joining
Accesso online:	https://www.mdpi.com/2079-7737/10/6/530

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