Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair

Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair

The earliest methods of genome editing, such as zinc-finger nucleases (ZFN) and transcription activator-like effector nucleases (TALENs), utilize customizable DNA-binding motifs to target the genome at specific loci. While these approaches provided sequence-specific gene-editing capacity, the labori...

Полное описание

Библиографические подробности
Главные авторы:	Marlo K. Thompson, Robert W. Sobol, Aishwarya Prakash
Формат:	Статья
Язык:	English
Опубликовано:	MDPI AG 2021-06-01
Серии:	Biology
Предметы:	CRISPR gene editing base excision repair mismatch repair homologous recombination non-homologous end-joining
Online-ссылка:	https://www.mdpi.com/2079-7737/10/6/530

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