Inhibition of angiogenetic macrophages reduces disc degeneration-associated pain

Inhibition of angiogenetic macrophages reduces disc degeneration-associated pain

Abnormal angiogenesis and innervation in avascular discs during lumbar disc degeneration (LDD) cause severe back pain. These pathological alterations in the degenerating discs are induced by cytokines partially produced and secreted by inflammatory cells, among which macrophages are the most frequen...

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Bibliographic Details
Main Authors: Yang Hou, Jiangang Shi, Yongfei Guo, Guodong Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
macrophage polarization
vascular endothelial growth factor A (VEGF-A)
angiogenesis
innervation
lumbar disc degeneration (LDD)
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.962155/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2022.962155/full

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