Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma
Background: Increasing evidence supports that lactate plays an important role in tumor proliferation, invasion and within the tumor microenvironment (TME). This is particularly relevant in lung adenocarcinoma (LUAD). Therefore, there is a current need to investigate lactate metabolism in LUAD patien...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.949310/full |
| _version_ | 1818496022520791040 |
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| author | Xiaoyan Chang Tong Lu Ran Xu Chenghao Wang Jiaying Zhao Linyou Zhang |
| author_facet | Xiaoyan Chang Tong Lu Ran Xu Chenghao Wang Jiaying Zhao Linyou Zhang |
| author_sort | Xiaoyan Chang |
| collection | DOAJ |
| description | Background: Increasing evidence supports that lactate plays an important role in tumor proliferation, invasion and within the tumor microenvironment (TME). This is particularly relevant in lung adenocarcinoma (LUAD). Therefore, there is a current need to investigate lactate metabolism in LUAD patients and how lactate metabolism is affected by different therapies.Methods: Data from LUAD patients were collected from The Cancer Genome Atlas (TCGA) and patients were divided into two subtypes according to 12 lactate metabolism-related genes to explore the effect of lactate metabolism in LUAD. We established a lactate-related prognostic indicator (LRPI) based on different gene expression profiles. Subsequently, we investigated associations between this LRPI and patient survival, molecular characteristics and response to therapy. Some analyses were conducted using the Genomics of Drug Sensitivity in Cancer (GDSC) database.Results: The two LUAD subtypes exhibited different levels of lactate metabolism, in which patients that displayed high lactate metabolism also had a worse prognosis and a poorer immune environment. Indeed, LRPI was shown to accurately predict the prognosis of LUAD patients. Patients with a high LRPI showed a poor prognosis coupled with high sensitivity to chemotherapy using GDSC data. Meanwhile, these patients exhibited a high responsiveness to immunotherapy in TMB (Tumor mutation burden) and TIDE (Tumor Immune Dysfunction and Exclusion) analyses.Conclusion: We validated the effect of lactate metabolism on the prognosis of LUAD patients and established a promising biomarker. LRPI can predict LUAD patient survival, molecular characteristics and response to therapy, which can aid the individualized treatment of LUAD patients. |
| first_indexed | 2024-12-10T18:27:58Z |
| format | Article |
| id | doaj.art-cab60f81bf8b4328837ebae0d4cfee5f |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T18:27:58Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-cab60f81bf8b4328837ebae0d4cfee5f2022-12-22T01:38:02ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.949310949310Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinomaXiaoyan ChangTong LuRan XuChenghao WangJiaying ZhaoLinyou ZhangBackground: Increasing evidence supports that lactate plays an important role in tumor proliferation, invasion and within the tumor microenvironment (TME). This is particularly relevant in lung adenocarcinoma (LUAD). Therefore, there is a current need to investigate lactate metabolism in LUAD patients and how lactate metabolism is affected by different therapies.Methods: Data from LUAD patients were collected from The Cancer Genome Atlas (TCGA) and patients were divided into two subtypes according to 12 lactate metabolism-related genes to explore the effect of lactate metabolism in LUAD. We established a lactate-related prognostic indicator (LRPI) based on different gene expression profiles. Subsequently, we investigated associations between this LRPI and patient survival, molecular characteristics and response to therapy. Some analyses were conducted using the Genomics of Drug Sensitivity in Cancer (GDSC) database.Results: The two LUAD subtypes exhibited different levels of lactate metabolism, in which patients that displayed high lactate metabolism also had a worse prognosis and a poorer immune environment. Indeed, LRPI was shown to accurately predict the prognosis of LUAD patients. Patients with a high LRPI showed a poor prognosis coupled with high sensitivity to chemotherapy using GDSC data. Meanwhile, these patients exhibited a high responsiveness to immunotherapy in TMB (Tumor mutation burden) and TIDE (Tumor Immune Dysfunction and Exclusion) analyses.Conclusion: We validated the effect of lactate metabolism on the prognosis of LUAD patients and established a promising biomarker. LRPI can predict LUAD patient survival, molecular characteristics and response to therapy, which can aid the individualized treatment of LUAD patients.https://www.frontiersin.org/articles/10.3389/fgene.2022.949310/fullimmune-related genesimmune checkpoint blockade therapylung adenocarcinomaprognosis biomarkerimmune cell infiltration |
| spellingShingle | Xiaoyan Chang Tong Lu Ran Xu Chenghao Wang Jiaying Zhao Linyou Zhang Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma Frontiers in Genetics immune-related genes immune checkpoint blockade therapy lung adenocarcinoma prognosis biomarker immune cell infiltration |
| title | Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma |
| title_full | Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma |
| title_fullStr | Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma |
| title_full_unstemmed | Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma |
| title_short | Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma |
| title_sort | identification of lactate metabolism related subtypes and development of a lactate related prognostic indicator of lung adenocarcinoma |
| topic | immune-related genes immune checkpoint blockade therapy lung adenocarcinoma prognosis biomarker immune cell infiltration |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.949310/full |
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