Location-Specific Oral Microbiome Possesses Features Associated With CKD
Chronic kidney disease (CKD), a progressive loss of renal function, can lead to serious complications if underdiagnosed. Many studies suggest that the oral microbiota plays important role in the health of the host; however, little is known about the association between the oral microbiota and CKD pa...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Kidney International Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024917303790 |
| _version_ | 1819112965532549120 |
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| author | Jianzhong Hu Srinivas Iragavarapu Girish N. Nadkarni Ruiqi Huang Monica Erazo Xiuliang Bao Divya Verghese Steven Coca Mairaj K. Ahmed Inga Peter |
| author_facet | Jianzhong Hu Srinivas Iragavarapu Girish N. Nadkarni Ruiqi Huang Monica Erazo Xiuliang Bao Divya Verghese Steven Coca Mairaj K. Ahmed Inga Peter |
| author_sort | Jianzhong Hu |
| collection | DOAJ |
| description | Chronic kidney disease (CKD), a progressive loss of renal function, can lead to serious complications if underdiagnosed. Many studies suggest that the oral microbiota plays important role in the health of the host; however, little is known about the association between the oral microbiota and CKD pathogenesis.
Methods: In this study, we surveyed the oral microbiota in saliva, the left and right molars, and the anterior mandibular lingual area from 77 participants (18 with and 59 without CKD), and tested their association with CKD to identify microbial features that may be predictive of CKD status.
Results: The overall oral microbiota composition significantly differed by oral locations and was associated with CKD status in saliva and anterior mandibular lingual samples. In CKD patients, we observed a significant enrichment of Neisseria and depletion of Veillonella in both sample types and a lower prevalence of Streptococcus in saliva after adjustment for other comorbidities. Furthermore, we detected a negative association of Neisseria and Streptococcus genera with the kidney function as measured by estimated glomerular filtration rate. Neisseria abundance also correlated with plasma interleukin-18 levels.
Conclusion: We demonstrate the association of the oral microbiome with CKD and inflammatory kidney biomarkers, highlighting a potential role of the commensal bacteria in CKD pathogenesis. A better understanding of the interplay between the oral microbiota and CKD may help in the development of new strategies to identify at-risk individuals or to serve as a novel target for therapeutic intervention. |
| first_indexed | 2024-12-22T04:21:53Z |
| format | Article |
| id | doaj.art-cab65e8116d4467e956098ffdb5eb24f |
| institution | Directory Open Access Journal |
| issn | 2468-0249 |
| language | English |
| last_indexed | 2024-12-22T04:21:53Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj.art-cab65e8116d4467e956098ffdb5eb24f2022-12-21T18:39:15ZengElsevierKidney International Reports2468-02492018-01-013119320410.1016/j.ekir.2017.08.018Location-Specific Oral Microbiome Possesses Features Associated With CKDJianzhong Hu0Srinivas Iragavarapu1Girish N. Nadkarni2Ruiqi Huang3Monica Erazo4Xiuliang Bao5Divya Verghese6Steven Coca7Mairaj K. Ahmed8Inga Peter9Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USACenter for Translational Orthodontic Research, Hoboken, New Jersey, USADepartment of Medicine, Division of Nephrology and the Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Medicine, Division of Nephrology and the Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Medicine, Division of Nephrology and the Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartments of Dentistry/Oral Maxillofacial Surgery, Otolaryngology and Plastic Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USAChronic kidney disease (CKD), a progressive loss of renal function, can lead to serious complications if underdiagnosed. Many studies suggest that the oral microbiota plays important role in the health of the host; however, little is known about the association between the oral microbiota and CKD pathogenesis. Methods: In this study, we surveyed the oral microbiota in saliva, the left and right molars, and the anterior mandibular lingual area from 77 participants (18 with and 59 without CKD), and tested their association with CKD to identify microbial features that may be predictive of CKD status. Results: The overall oral microbiota composition significantly differed by oral locations and was associated with CKD status in saliva and anterior mandibular lingual samples. In CKD patients, we observed a significant enrichment of Neisseria and depletion of Veillonella in both sample types and a lower prevalence of Streptococcus in saliva after adjustment for other comorbidities. Furthermore, we detected a negative association of Neisseria and Streptococcus genera with the kidney function as measured by estimated glomerular filtration rate. Neisseria abundance also correlated with plasma interleukin-18 levels. Conclusion: We demonstrate the association of the oral microbiome with CKD and inflammatory kidney biomarkers, highlighting a potential role of the commensal bacteria in CKD pathogenesis. A better understanding of the interplay between the oral microbiota and CKD may help in the development of new strategies to identify at-risk individuals or to serve as a novel target for therapeutic intervention.http://www.sciencedirect.com/science/article/pii/S2468024917303790chronic kidney diseasedental plaqueoral microbiomesaliva |
| spellingShingle | Jianzhong Hu Srinivas Iragavarapu Girish N. Nadkarni Ruiqi Huang Monica Erazo Xiuliang Bao Divya Verghese Steven Coca Mairaj K. Ahmed Inga Peter Location-Specific Oral Microbiome Possesses Features Associated With CKD Kidney International Reports chronic kidney disease dental plaque oral microbiome saliva |
| title | Location-Specific Oral Microbiome Possesses Features Associated With CKD |
| title_full | Location-Specific Oral Microbiome Possesses Features Associated With CKD |
| title_fullStr | Location-Specific Oral Microbiome Possesses Features Associated With CKD |
| title_full_unstemmed | Location-Specific Oral Microbiome Possesses Features Associated With CKD |
| title_short | Location-Specific Oral Microbiome Possesses Features Associated With CKD |
| title_sort | location specific oral microbiome possesses features associated with ckd |
| topic | chronic kidney disease dental plaque oral microbiome saliva |
| url | http://www.sciencedirect.com/science/article/pii/S2468024917303790 |
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