Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-based in silico model using single-cell mechanomics

Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-based in silico model using single-cell mechanomics

Bone remodeling is regulated by the interaction between different cells and tissues across many spatial and temporal scales. Notably, in silico models are regarded as powerful tools to further understand the signaling pathways that regulate this intricate spatial cellular interplay. To this end, we...

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Bibliographic Details
Main Authors: Daniele Boaretti, Francisco C. Marques, Charles Ledoux, Amit Singh, Jack J. Kendall, Esther Wehrle, Gisela A. Kuhn, Yogesh D. Bansod, Friederike A. Schulte, Ralph Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
micro-FE
bone adaptation
mechanical signal
numerical simulations
bone cells
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1091294/full

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