Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers
Abstract The study enrolled 284 patients with chronic hepatitis B virus infection. Participants included people with mild fibrotic lesions (32.5%), moderate to severe fibrotic lesions (27.5%), cirrhotic lesions (22%), hepatocellular carcinoma (HCC) in 5%, and people with no fibrotic lesions in 13%....
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32753-8 |
| _version_ | 1797845970595086336 |
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| author | Magda Rybicka Eloi R. Verrier Thomas F. Baumert Krzysztof Piotr Bielawski |
| author_facet | Magda Rybicka Eloi R. Verrier Thomas F. Baumert Krzysztof Piotr Bielawski |
| author_sort | Magda Rybicka |
| collection | DOAJ |
| description | Abstract The study enrolled 284 patients with chronic hepatitis B virus infection. Participants included people with mild fibrotic lesions (32.5%), moderate to severe fibrotic lesions (27.5%), cirrhotic lesions (22%), hepatocellular carcinoma (HCC) in 5%, and people with no fibrotic lesions in 13%. Eleven SNPs within DIO2, PPARG, ATF3, AKT, GADD45A, and TBX21 were genotyped by mass spectrometry. The rs225014 TT (DIO2) and rs10865710 CC (PPARG) genotypes were independently associated with susceptibility to advanced liver fibrosis. However, cirrhosis was more prevalent in individuals with the GADD45A rs532446 TT and ATF3 rs11119982 TT genotypes. In addition, the rs225014 CC variant of DIO2 was more frequently found in patients with a diagnosis of HCC. These findings suggest that the above SNPs may play a role in HBV-induced liver damage in a Caucasian population. |
| first_indexed | 2024-04-09T17:48:37Z |
| format | Article |
| id | doaj.art-cab850d967bc4f398999ca44affecbe3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T17:48:37Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cab850d967bc4f398999ca44affecbe32023-04-16T11:13:26ZengNature PortfolioScientific Reports2045-23222023-04-0113111110.1038/s41598-023-32753-8Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriersMagda Rybicka0Eloi R. Verrier1Thomas F. Baumert2Krzysztof Piotr Bielawski3Department of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of GdanskInserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, Université de StrasbourgInserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, Université de StrasbourgDepartment of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of GdanskAbstract The study enrolled 284 patients with chronic hepatitis B virus infection. Participants included people with mild fibrotic lesions (32.5%), moderate to severe fibrotic lesions (27.5%), cirrhotic lesions (22%), hepatocellular carcinoma (HCC) in 5%, and people with no fibrotic lesions in 13%. Eleven SNPs within DIO2, PPARG, ATF3, AKT, GADD45A, and TBX21 were genotyped by mass spectrometry. The rs225014 TT (DIO2) and rs10865710 CC (PPARG) genotypes were independently associated with susceptibility to advanced liver fibrosis. However, cirrhosis was more prevalent in individuals with the GADD45A rs532446 TT and ATF3 rs11119982 TT genotypes. In addition, the rs225014 CC variant of DIO2 was more frequently found in patients with a diagnosis of HCC. These findings suggest that the above SNPs may play a role in HBV-induced liver damage in a Caucasian population.https://doi.org/10.1038/s41598-023-32753-8 |
| spellingShingle | Magda Rybicka Eloi R. Verrier Thomas F. Baumert Krzysztof Piotr Bielawski Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers Scientific Reports |
| title | Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers |
| title_full | Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers |
| title_fullStr | Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers |
| title_full_unstemmed | Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers |
| title_short | Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers |
| title_sort | polymorphisms within dio2 and gadd45a genes increase the risk of liver disease progression in chronic hepatitis b carriers |
| url | https://doi.org/10.1038/s41598-023-32753-8 |
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