New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum
Seco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical tra...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-06-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/7/2/249/ |
| _version_ | 1811185179360755712 |
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| author | Reiko Tanaka Yasuhide Muroga Takeshi Yamada |
| author_facet | Reiko Tanaka Yasuhide Muroga Takeshi Yamada |
| author_sort | Reiko Tanaka |
| collection | DOAJ |
| description | Seco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical transformation from known chaetomugilins A and D. Seco-chaetomugilin D exhibited growth inhibitory activity against cultured P388, HL-60, L1210, and KB cells. |
| first_indexed | 2024-04-11T13:26:05Z |
| format | Article |
| id | doaj.art-cab8a8eab43743509b2efa8f56e9961d |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:26:05Z |
| publishDate | 2009-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-cab8a8eab43743509b2efa8f56e9961d2022-12-22T04:22:05ZengMDPI AGMarine Drugs1660-33972009-06-017224925710.3390/md7020249New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosumReiko TanakaYasuhide MurogaTakeshi YamadaSeco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical transformation from known chaetomugilins A and D. Seco-chaetomugilin D exhibited growth inhibitory activity against cultured P388, HL-60, L1210, and KB cells.http://www.mdpi.com/1660-3397/7/2/249/fungusmarine-fishChaetomium globosumcytotoxicitychaetomugilinsazaphiloneschemical transformationalkaline degradation |
| spellingShingle | Reiko Tanaka Yasuhide Muroga Takeshi Yamada New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum Marine Drugs fungus marine-fish Chaetomium globosum cytotoxicity chaetomugilins azaphilones chemical transformation alkaline degradation |
| title | New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum |
| title_full | New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum |
| title_fullStr | New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum |
| title_full_unstemmed | New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum |
| title_short | New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum |
| title_sort | new azaphilones seco chaetomugilins a and d produced by a marine fish derived chaetomium globosum |
| topic | fungus marine-fish Chaetomium globosum cytotoxicity chaetomugilins azaphilones chemical transformation alkaline degradation |
| url | http://www.mdpi.com/1660-3397/7/2/249/ |
| work_keys_str_mv | AT reikotanaka newazaphilonessecochaetomugilinsaanddproducedbyamarinefishderivedchaetomiumglobosum AT yasuhidemuroga newazaphilonessecochaetomugilinsaanddproducedbyamarinefishderivedchaetomiumglobosum AT takeshiyamada newazaphilonessecochaetomugilinsaanddproducedbyamarinefishderivedchaetomiumglobosum |