COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes
(1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (C<sub>T</sub>) values. (2) This was a retrospective case-control study in a third-level hea...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/9/1884 |
| _version_ | 1797516954817265664 |
|---|---|
| author | Estibalitz Laresgoiti-Servitje Jorge Arturo Cardona-Pérez Rosa Gabriela Hernández-Cruz Addy Cecilia Helguera-Repetto María Yolotzin Valdespino-Vázquez Elsa Romelia Moreno-Verduzco Isabel Villegas-Mota Sandra Acevedo-Gallegos Mario Rodríguez-Bosch Moisés León-Juárez Mónica Aguinaga-Ríos Irma Coronado-Zarco Alejandro Ortiz-Calvillo María Antonieta Rivera-Rueda Carolina Valencia-Contreras María de Lourdes Gómez-Sousa Mario Solis-Paredes Juan Carlos Rodriguez-Aldama Rafael Galván-Contreras Ricardo Figueroa-Damián Manuel Cortés-Bonilla Guadalupe Estrada-Gutierrez Salvador Espino-y-Sosa Claudine Irles |
| author_facet | Estibalitz Laresgoiti-Servitje Jorge Arturo Cardona-Pérez Rosa Gabriela Hernández-Cruz Addy Cecilia Helguera-Repetto María Yolotzin Valdespino-Vázquez Elsa Romelia Moreno-Verduzco Isabel Villegas-Mota Sandra Acevedo-Gallegos Mario Rodríguez-Bosch Moisés León-Juárez Mónica Aguinaga-Ríos Irma Coronado-Zarco Alejandro Ortiz-Calvillo María Antonieta Rivera-Rueda Carolina Valencia-Contreras María de Lourdes Gómez-Sousa Mario Solis-Paredes Juan Carlos Rodriguez-Aldama Rafael Galván-Contreras Ricardo Figueroa-Damián Manuel Cortés-Bonilla Guadalupe Estrada-Gutierrez Salvador Espino-y-Sosa Claudine Irles |
| author_sort | Estibalitz Laresgoiti-Servitje |
| collection | DOAJ |
| description | (1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (C<sub>T</sub>) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and C<sub>T</sub> values were assessed by logistic regression models and decision trees. (3) Accordingly, 828 and 298 women had a negative and positive test, respectively. Of those positive, only 2.6% of them presented mild to moderate symptoms. Clinical characteristics between both groups of women were similar. No associations between C<sub>T</sub> values were found for maternal features, such as pre-gestational BMI, age, and symptomatology. A significantly higher percentage of placental fibrinoid was seen with women with low C<sub>T</sub>s (<25; <i>p</i> < 0.01). Regarding perinatal outcomes, preeclampsia was found to be significantly associated with symptomatology but not with risk factors or C<sub>T</sub> values (<i>p</i> < 0.01, aOR = 14.72). Moreover, 88.9% of women diagnosed with COVID-19 at <35 gestational weeks and symptomatic developed preeclampsia. (4) The data support strong guidance for pregnancies with SARS-CoV-2 infection, in particular preeclampsia and placental pathology, which need further investigation. |
| first_indexed | 2024-03-10T07:08:04Z |
| format | Article |
| id | doaj.art-cabbe2cefb8b4f61b8c472eaba46d900 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T07:08:04Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-cabbe2cefb8b4f61b8c472eaba46d9002023-11-22T15:39:29ZengMDPI AGViruses1999-49152021-09-01139188410.3390/v13091884COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal OutcomesEstibalitz Laresgoiti-Servitje0Jorge Arturo Cardona-Pérez1Rosa Gabriela Hernández-Cruz2Addy Cecilia Helguera-Repetto3María Yolotzin Valdespino-Vázquez4Elsa Romelia Moreno-Verduzco5Isabel Villegas-Mota6Sandra Acevedo-Gallegos7Mario Rodríguez-Bosch8Moisés León-Juárez9Mónica Aguinaga-Ríos10Irma Coronado-Zarco11Alejandro Ortiz-Calvillo12María Antonieta Rivera-Rueda13Carolina Valencia-Contreras14María de Lourdes Gómez-Sousa15Mario Solis-Paredes16Juan Carlos Rodriguez-Aldama17Rafael Galván-Contreras18Ricardo Figueroa-Damián19Manuel Cortés-Bonilla20Guadalupe Estrada-Gutierrez21Salvador Espino-y-Sosa22Claudine Irles23Clinical Sciences, School of Medicine and Health Sciences, Tecnológico de Monterrey, Mexico City 64849, MexicoDirección General, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Fomento y Herramientas Educativas, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Immunobioquímica, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Anatomía Patológica, Instituto Nacional de Perinatología, Mexico City 11000, MexicoSubdirección de Servicios Auxiliares de Diagnóstico, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Enfermedades Infecciosas e Epidemiología, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Medicina Materno-Fetal, Instituto Nacional de Perinatología, Mexico City 11000, MexicoSubdirección de Ginecología e Obstetricia, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Immunobioquímica, Instituto Nacional de Perinatología, Mexico City 11000, MexicoCoordinación de Genética Clínica, Departamento de Medicina Materno-Fetal, Instituto Nacional de Perinatología, Mexico City 11000, MexicoSubdirección de Neonatología, Instituto Nacional de Perinatología, Mexico City 11000, MexicoSubdirección de Investigación Clínica, Instituto Nacional de Perinatología, Mexico City 11000, MexicoUnidad de Cuidados Intensivos del Recién Nacido, Instituto Nacional de Perinatología, Mexico City 11000, MexicoUnidad de Cuidados Intermedios del Recién Nacido, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Posgrado e Investigación, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Genética y Genómica Humana, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Enfermedades Infecciosas e Epidemiología, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Enfermedades Infecciosas e Epidemiología, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Infectología e Inmunología, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDirección Médica, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDirección de Investigación, Instituto Nacional de Perinatología, Mexico City 11000, MexicoSubdirección de Investigación Clínica, Instituto Nacional de Perinatología, Mexico City 11000, MexicoDepartamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología, Mexico City 11000, Mexico(1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (C<sub>T</sub>) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and C<sub>T</sub> values were assessed by logistic regression models and decision trees. (3) Accordingly, 828 and 298 women had a negative and positive test, respectively. Of those positive, only 2.6% of them presented mild to moderate symptoms. Clinical characteristics between both groups of women were similar. No associations between C<sub>T</sub> values were found for maternal features, such as pre-gestational BMI, age, and symptomatology. A significantly higher percentage of placental fibrinoid was seen with women with low C<sub>T</sub>s (<25; <i>p</i> < 0.01). Regarding perinatal outcomes, preeclampsia was found to be significantly associated with symptomatology but not with risk factors or C<sub>T</sub> values (<i>p</i> < 0.01, aOR = 14.72). Moreover, 88.9% of women diagnosed with COVID-19 at <35 gestational weeks and symptomatic developed preeclampsia. (4) The data support strong guidance for pregnancies with SARS-CoV-2 infection, in particular preeclampsia and placental pathology, which need further investigation.https://www.mdpi.com/1999-4915/13/9/1884SARS-CoV-2pregnancyhypertensive disorderplacenta |
| spellingShingle | Estibalitz Laresgoiti-Servitje Jorge Arturo Cardona-Pérez Rosa Gabriela Hernández-Cruz Addy Cecilia Helguera-Repetto María Yolotzin Valdespino-Vázquez Elsa Romelia Moreno-Verduzco Isabel Villegas-Mota Sandra Acevedo-Gallegos Mario Rodríguez-Bosch Moisés León-Juárez Mónica Aguinaga-Ríos Irma Coronado-Zarco Alejandro Ortiz-Calvillo María Antonieta Rivera-Rueda Carolina Valencia-Contreras María de Lourdes Gómez-Sousa Mario Solis-Paredes Juan Carlos Rodriguez-Aldama Rafael Galván-Contreras Ricardo Figueroa-Damián Manuel Cortés-Bonilla Guadalupe Estrada-Gutierrez Salvador Espino-y-Sosa Claudine Irles COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes Viruses SARS-CoV-2 pregnancy hypertensive disorder placenta |
| title | COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes |
| title_full | COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes |
| title_fullStr | COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes |
| title_full_unstemmed | COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes |
| title_short | COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes |
| title_sort | covid 19 infection in pregnancy pcr cycle thresholds placental pathology and perinatal outcomes |
| topic | SARS-CoV-2 pregnancy hypertensive disorder placenta |
| url | https://www.mdpi.com/1999-4915/13/9/1884 |
| work_keys_str_mv | AT estibalitzlaresgoitiservitje covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT jorgearturocardonaperez covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT rosagabrielahernandezcruz covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT addyceciliahelguerarepetto covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT mariayolotzinvaldespinovazquez covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT elsaromeliamorenoverduzco covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT isabelvillegasmota covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT sandraacevedogallegos covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT mariorodriguezbosch covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT moisesleonjuarez covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT monicaaguinagarios covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT irmacoronadozarco covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT alejandroortizcalvillo covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT mariaantonietariverarueda covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT carolinavalenciacontreras covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT mariadelourdesgomezsousa covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT mariosolisparedes covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT juancarlosrodriguezaldama covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT rafaelgalvancontreras covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT ricardofigueroadamian covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT manuelcortesbonilla covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT guadalupeestradagutierrez covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT salvadorespinoysosa covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes AT claudineirles covid19infectioninpregnancypcrcyclethresholdsplacentalpathologyandperinataloutcomes |