The Herbal Medicine () for Sleep Quality Improvements: A Systematic Review and Meta-analysis
Background: Sleep disturbances are common and bothersome among cancer and noncancer populations. Suanzaoren ( Ziziphi Spinosae Semen ) is commonly used to improve sleep, yet its efficacy and safety are unclear. Methods: We systematically searched PubMed, Cochrane Library, and EMBASE from inception t...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-04-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354231162080 |
| _version_ | 1797852538614054912 |
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| author | Mingxiao Yang PhD Hui Wang PhD Yi Lily Zhang DPT Furong Zhang PhD Xiaotong Li PhD Soo-Dam Kim PhD Yalan Chen MMed Jiyao Chen MMed Susan Chimonas PhD Deborah Korenstein MD Jun J. Mao MD, MSCE |
| author_facet | Mingxiao Yang PhD Hui Wang PhD Yi Lily Zhang DPT Furong Zhang PhD Xiaotong Li PhD Soo-Dam Kim PhD Yalan Chen MMed Jiyao Chen MMed Susan Chimonas PhD Deborah Korenstein MD Jun J. Mao MD, MSCE |
| author_sort | Mingxiao Yang PhD |
| collection | DOAJ |
| description | Background: Sleep disturbances are common and bothersome among cancer and noncancer populations. Suanzaoren ( Ziziphi Spinosae Semen ) is commonly used to improve sleep, yet its efficacy and safety are unclear. Methods: We systematically searched PubMed, Cochrane Library, and EMBASE from inception through October 5, 2021, to identify randomized trials of Suanzaoren . We included randomized trials comparing Suanzaoren to placebo, medications, cognitive behavioral therapy (CBT), or usual care for improving sleep outcomes in cancer and noncancer patients with insomnia or sleep disturbance. We performed a risk of bias analysis following Cochrane guidelines. Depending on heterogeneity, we pooled studies with similar comparators using fixed- and random-effects models. Results: We included participants with insomnia disorder (N = 785) or sleep disturbance (N = 120) from 9 trials. Compared with placebo, Suanzaoren led to significant subjective sleep quality improvements in participants with insomnia and patients with sleep disturbance combined (standard mean difference −0.58, 95% CI −1.04, −0.11; P < .01); Compared with benzodiazepines or CBT, Suanzaoren was associated with a significant decrease in insomnia severity (mean difference −2.68 points, 95% CI −5.50, −0.22; P = .03) at 4 weeks in the general population and cancer patients. The long-term effects of Suanzaoren were mixed among trials. Suanzaoren did not increase the incidence of major adverse events. The placebo-controlled studies had a low risk of bias. Conclusion: Suanzaoren is associated with short-term patient-reported sleep quality improvements among individuals with insomnia or sleep disturbance. Due to the small sample size and variable study quality, the clinical benefits and harms of Suanzaoren , particularly in the long term, should be further assessed in a sufficiently powered randomized trial. Registration: PROSPERO CRD42021281943 |
| first_indexed | 2024-04-09T19:34:57Z |
| format | Article |
| id | doaj.art-cabcffd38eb44249920d9b709aabb9ae |
| institution | Directory Open Access Journal |
| issn | 1552-695X |
| language | English |
| last_indexed | 2024-04-09T19:34:57Z |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-cabcffd38eb44249920d9b709aabb9ae2023-04-04T13:33:54ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2023-04-012210.1177/15347354231162080The Herbal Medicine () for Sleep Quality Improvements: A Systematic Review and Meta-analysisMingxiao Yang PhD0Hui Wang PhD1Yi Lily Zhang DPT2Furong Zhang PhD3Xiaotong Li PhD4Soo-Dam Kim PhD5Yalan Chen MMed6Jiyao Chen MMed7Susan Chimonas PhD8Deborah Korenstein MD9Jun J. Mao MD, MSCE10Memorial Sloan Kettering Cancer Center, New York, NY, USAChina Academy of Chinese Medical Sciences, Beijing, ChinaMemorial Sloan Kettering Cancer Center, New York, NY, USAChengdu University of Traditional Chinese Medicine, Chengdu, ChinaMemorial Sloan Kettering Cancer Center, New York, NY, USADaejeon University, Dong-gu, Daejeon, Republic of KoreaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaMemorial Sloan Kettering Cancer Center, New York, NY, USAWeill Cornell Medical College, New York, NY, USAMemorial Sloan Kettering Cancer Center, New York, NY, USABackground: Sleep disturbances are common and bothersome among cancer and noncancer populations. Suanzaoren ( Ziziphi Spinosae Semen ) is commonly used to improve sleep, yet its efficacy and safety are unclear. Methods: We systematically searched PubMed, Cochrane Library, and EMBASE from inception through October 5, 2021, to identify randomized trials of Suanzaoren . We included randomized trials comparing Suanzaoren to placebo, medications, cognitive behavioral therapy (CBT), or usual care for improving sleep outcomes in cancer and noncancer patients with insomnia or sleep disturbance. We performed a risk of bias analysis following Cochrane guidelines. Depending on heterogeneity, we pooled studies with similar comparators using fixed- and random-effects models. Results: We included participants with insomnia disorder (N = 785) or sleep disturbance (N = 120) from 9 trials. Compared with placebo, Suanzaoren led to significant subjective sleep quality improvements in participants with insomnia and patients with sleep disturbance combined (standard mean difference −0.58, 95% CI −1.04, −0.11; P < .01); Compared with benzodiazepines or CBT, Suanzaoren was associated with a significant decrease in insomnia severity (mean difference −2.68 points, 95% CI −5.50, −0.22; P = .03) at 4 weeks in the general population and cancer patients. The long-term effects of Suanzaoren were mixed among trials. Suanzaoren did not increase the incidence of major adverse events. The placebo-controlled studies had a low risk of bias. Conclusion: Suanzaoren is associated with short-term patient-reported sleep quality improvements among individuals with insomnia or sleep disturbance. Due to the small sample size and variable study quality, the clinical benefits and harms of Suanzaoren , particularly in the long term, should be further assessed in a sufficiently powered randomized trial. Registration: PROSPERO CRD42021281943https://doi.org/10.1177/15347354231162080 |
| spellingShingle | Mingxiao Yang PhD Hui Wang PhD Yi Lily Zhang DPT Furong Zhang PhD Xiaotong Li PhD Soo-Dam Kim PhD Yalan Chen MMed Jiyao Chen MMed Susan Chimonas PhD Deborah Korenstein MD Jun J. Mao MD, MSCE The Herbal Medicine () for Sleep Quality Improvements: A Systematic Review and Meta-analysis Integrative Cancer Therapies |
| title | The Herbal Medicine () for Sleep Quality Improvements: A Systematic Review and Meta-analysis |
| title_full | The Herbal Medicine () for Sleep Quality Improvements: A Systematic Review and Meta-analysis |
| title_fullStr | The Herbal Medicine () for Sleep Quality Improvements: A Systematic Review and Meta-analysis |
| title_full_unstemmed | The Herbal Medicine () for Sleep Quality Improvements: A Systematic Review and Meta-analysis |
| title_short | The Herbal Medicine () for Sleep Quality Improvements: A Systematic Review and Meta-analysis |
| title_sort | herbal medicine for sleep quality improvements a systematic review and meta analysis |
| url | https://doi.org/10.1177/15347354231162080 |
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