Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling

Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling

Abstract Background Phelan–McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, and autistic-like behaviors and is primarily caused by haploinsufficiency of SHANK3 gene. Currently, there is no specific treatment for PMS, highlighting...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Jessica Pagano, Silvia Landi, Alessia Stefanoni, Gabriele Nardi, Marica Albanesi, Helen F. Bauer, Enrico Pracucci, Michael Schön, Gian Michele Ratto, Tobias M. Boeckers, Carlo Sala, Chiara Verpelli
التنسيق: مقال
اللغة:English
منشور في: BMC 2023-08-01
سلاسل:Molecular Autism
الموضوعات:
Autism
Hyperexcitability
Ganaxolone
GABAA receptor
الوصول للمادة أونلاين:https://doi.org/10.1186/s13229-023-00557-2

الانترنت

https://doi.org/10.1186/s13229-023-00557-2

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