Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling

Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling

Abstract Background Phelan–McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, and autistic-like behaviors and is primarily caused by haploinsufficiency of SHANK3 gene. Currently, there is no specific treatment for PMS, highlighting...

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Bibliografiska uppgifter
Huvudupphovsmän: Jessica Pagano, Silvia Landi, Alessia Stefanoni, Gabriele Nardi, Marica Albanesi, Helen F. Bauer, Enrico Pracucci, Michael Schön, Gian Michele Ratto, Tobias M. Boeckers, Carlo Sala, Chiara Verpelli
Materialtyp: Artikel
Språk:English
Publicerad: BMC 2023-08-01
Serie:Molecular Autism
Ämnen:
Autism
Hyperexcitability
Ganaxolone
GABAA receptor
Länkar:https://doi.org/10.1186/s13229-023-00557-2

Internet

https://doi.org/10.1186/s13229-023-00557-2

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