Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling

Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling

Abstract Background Phelan–McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, and autistic-like behaviors and is primarily caused by haploinsufficiency of SHANK3 gene. Currently, there is no specific treatment for PMS, highlighting...

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Main Authors: Jessica Pagano, Silvia Landi, Alessia Stefanoni, Gabriele Nardi, Marica Albanesi, Helen F. Bauer, Enrico Pracucci, Michael Schön, Gian Michele Ratto, Tobias M. Boeckers, Carlo Sala, Chiara Verpelli
格式: Article
語言:English
出版: BMC 2023-08-01
叢編:Molecular Autism
主題:
Autism
Hyperexcitability
Ganaxolone
GABAA receptor
在線閱讀:https://doi.org/10.1186/s13229-023-00557-2

因特網

https://doi.org/10.1186/s13229-023-00557-2

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