c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae
Biofilm formation by Vibrio cholerae is regulated by c-di-GMP and requires the type IV MSHA pilus. Here, Floyd et al. show that the MSHA pilus is a dynamic system, and that both extension and retraction are directly controlled by c-di-GMP via regulation of activity of the extension ATPase MshE.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15331-8 |
| _version_ | 1818343246567309312 |
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| author | Kyle A. Floyd Calvin K. Lee Wujing Xian Mahmoud Nametalla Aneesa Valentine Benjamin Crair Shiwei Zhu Hannah Q. Hughes Jennifer L. Chlebek Daniel C. Wu Jin Hwan Park Ali M. Farhat Charles J. Lomba Courtney K. Ellison Yves V. Brun Javier Campos-Gomez Ankur B. Dalia Jun Liu Nicolas Biais Gerard C. L. Wong Fitnat H. Yildiz |
| author_facet | Kyle A. Floyd Calvin K. Lee Wujing Xian Mahmoud Nametalla Aneesa Valentine Benjamin Crair Shiwei Zhu Hannah Q. Hughes Jennifer L. Chlebek Daniel C. Wu Jin Hwan Park Ali M. Farhat Charles J. Lomba Courtney K. Ellison Yves V. Brun Javier Campos-Gomez Ankur B. Dalia Jun Liu Nicolas Biais Gerard C. L. Wong Fitnat H. Yildiz |
| author_sort | Kyle A. Floyd |
| collection | DOAJ |
| description | Biofilm formation by Vibrio cholerae is regulated by c-di-GMP and requires the type IV MSHA pilus. Here, Floyd et al. show that the MSHA pilus is a dynamic system, and that both extension and retraction are directly controlled by c-di-GMP via regulation of activity of the extension ATPase MshE. |
| first_indexed | 2024-12-13T16:27:32Z |
| format | Article |
| id | doaj.art-cabf8badabb34c2f9c45f7702f8ed372 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:27:32Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cabf8badabb34c2f9c45f7702f8ed3722022-12-21T23:38:34ZengNature PortfolioNature Communications2041-17232020-03-0111111610.1038/s41467-020-15331-8c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio choleraeKyle A. Floyd0Calvin K. Lee1Wujing Xian2Mahmoud Nametalla3Aneesa Valentine4Benjamin Crair5Shiwei Zhu6Hannah Q. Hughes7Jennifer L. Chlebek8Daniel C. Wu9Jin Hwan Park10Ali M. Farhat11Charles J. Lomba12Courtney K. Ellison13Yves V. Brun14Javier Campos-Gomez15Ankur B. Dalia16Jun Liu17Nicolas Biais18Gerard C. L. Wong19Fitnat H. Yildiz20Department of Microbiology and Environmental Toxicology, University of California – Santa CruzDepartments of Bioengineering, Chemistry and Biochemistry, California Nano Systems Institute, University of California – Los AngelesDepartments of Bioengineering, Chemistry and Biochemistry, California Nano Systems Institute, University of California – Los AngelesDepartment of Biology, Brooklyn CollegeDepartment of Biology, Brooklyn CollegeDepartment of Microbial Pathogenesis, Yale UniversityDepartment of Microbial Pathogenesis, Yale UniversityDepartment of Biology, Indiana University – BloomingtonDepartment of Biology, Indiana University – BloomingtonDepartment of Microbiology and Environmental Toxicology, University of California – Santa CruzDepartment of Microbiology and Environmental Toxicology, University of California – Santa CruzDepartments of Bioengineering, Chemistry and Biochemistry, California Nano Systems Institute, University of California – Los AngelesDepartments of Bioengineering, Chemistry and Biochemistry, California Nano Systems Institute, University of California – Los AngelesDepartment of Biology, Indiana University – BloomingtonDepartment of Microbiology, Infectious Diseases, and Immunology, Faculty of Medicine, University of MontrealCystic Fibrosis Research Center, University of Alabama at BirminghamDepartment of Biology, Indiana University – BloomingtonDepartment of Microbial Pathogenesis, Yale UniversityDepartment of Biology, Brooklyn CollegeDepartments of Bioengineering, Chemistry and Biochemistry, California Nano Systems Institute, University of California – Los AngelesDepartment of Microbiology and Environmental Toxicology, University of California – Santa CruzBiofilm formation by Vibrio cholerae is regulated by c-di-GMP and requires the type IV MSHA pilus. Here, Floyd et al. show that the MSHA pilus is a dynamic system, and that both extension and retraction are directly controlled by c-di-GMP via regulation of activity of the extension ATPase MshE.https://doi.org/10.1038/s41467-020-15331-8 |
| spellingShingle | Kyle A. Floyd Calvin K. Lee Wujing Xian Mahmoud Nametalla Aneesa Valentine Benjamin Crair Shiwei Zhu Hannah Q. Hughes Jennifer L. Chlebek Daniel C. Wu Jin Hwan Park Ali M. Farhat Charles J. Lomba Courtney K. Ellison Yves V. Brun Javier Campos-Gomez Ankur B. Dalia Jun Liu Nicolas Biais Gerard C. L. Wong Fitnat H. Yildiz c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae Nature Communications |
| title | c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae |
| title_full | c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae |
| title_fullStr | c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae |
| title_full_unstemmed | c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae |
| title_short | c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae |
| title_sort | c di gmp modulates type iv msha pilus retraction and surface attachment in vibrio cholerae |
| url | https://doi.org/10.1038/s41467-020-15331-8 |
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