The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

Background: Evidence supports an important link between mitochondrial DNA (mtDNA) variation and adverse drug reactions such as idiosyncratic drug-induced liver injury (iDILI). Here, we describe the generation of HepG2-derived transmitochondrial cybrids, to investigate the impact of mtDNA variation o...

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Bibliographic Details
Main Authors: Amy Louise Ball, Carol E Jolly, Mark G Lennon, Jonathan J Lyon, Ana Alfirevic, Amy E Chadwick
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
mitochondria
drug safety
mtDNA
drug-induced liver injury
transmitochondrial cybrid
HepG2
Online Access:https://elifesciences.org/articles/78187

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