Biodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature
Abstract Stimuli-responsive controlled delivery systems are of interest for preventing premature leakages and ensuring precise releases of active compounds at target sites. In this study, porous biodegradable micro/nanoparticles embedded with thermoresponsive gatekeepers are designed and developed b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15069-x |
| _version_ | 1817976658317017088 |
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| author | Kamonchanok Thananukul Chariya Kaewsaneha Pakorn Opaprakasit Nadia Zine Abdelhamid Elaissari |
| author_facet | Kamonchanok Thananukul Chariya Kaewsaneha Pakorn Opaprakasit Nadia Zine Abdelhamid Elaissari |
| author_sort | Kamonchanok Thananukul |
| collection | DOAJ |
| description | Abstract Stimuli-responsive controlled delivery systems are of interest for preventing premature leakages and ensuring precise releases of active compounds at target sites. In this study, porous biodegradable micro/nanoparticles embedded with thermoresponsive gatekeepers are designed and developed based on Eudragit RS100 (PNIPAM@RS100) and poly(N-isopropylacrylamide) via a double emulsion solvent evaporation technique. The effect of initiator types on the polymerization of NIPAM monomer/methylene-bis-acrylamide (MBA) crosslinker was investigated at 60 °C for thermal initiators and ambient temperature for redox initiators. The crosslinked PNIPAM plays a key role as thermal-triggered gatekeepers with high loading efficiency and precise release of a model active compound, Nile Blue A (NB). Below the volume phase transition temperature (TVPT), the gatekeepers possess a swollen conformation to block the pores and store NB within the cavities. Above its TVPT, the chains rearrange, allowing gate opening and a rapid and constant release rate of the compound until completion. A precise “on–off” switchable release efficiency of PNIPAM@RS100 was demonstrated by changing the temperatures to 4 and 40 °C. The materials are a promising candidate for controlled drug delivery systems with a precise and easy triggering mechanism at the body temperature for effective treatments. |
| first_indexed | 2024-04-13T22:05:37Z |
| format | Article |
| id | doaj.art-cac0d80872f74abda87a73b3eb1c4779 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T22:05:37Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cac0d80872f74abda87a73b3eb1c47792022-12-22T02:27:57ZengNature PortfolioScientific Reports2045-23222022-06-0112111410.1038/s41598-022-15069-xBiodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperatureKamonchanok Thananukul0Chariya Kaewsaneha1Pakorn Opaprakasit2Nadia Zine3Abdelhamid Elaissari4School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat UniversitySchool of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat UniversitySchool of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat UniversityUniv Lyon, University Claude Bernard Lyon-1, CNRS, ISA-UMR 5280Univ Lyon, University Claude Bernard Lyon-1, CNRS, ISA-UMR 5280Abstract Stimuli-responsive controlled delivery systems are of interest for preventing premature leakages and ensuring precise releases of active compounds at target sites. In this study, porous biodegradable micro/nanoparticles embedded with thermoresponsive gatekeepers are designed and developed based on Eudragit RS100 (PNIPAM@RS100) and poly(N-isopropylacrylamide) via a double emulsion solvent evaporation technique. The effect of initiator types on the polymerization of NIPAM monomer/methylene-bis-acrylamide (MBA) crosslinker was investigated at 60 °C for thermal initiators and ambient temperature for redox initiators. The crosslinked PNIPAM plays a key role as thermal-triggered gatekeepers with high loading efficiency and precise release of a model active compound, Nile Blue A (NB). Below the volume phase transition temperature (TVPT), the gatekeepers possess a swollen conformation to block the pores and store NB within the cavities. Above its TVPT, the chains rearrange, allowing gate opening and a rapid and constant release rate of the compound until completion. A precise “on–off” switchable release efficiency of PNIPAM@RS100 was demonstrated by changing the temperatures to 4 and 40 °C. The materials are a promising candidate for controlled drug delivery systems with a precise and easy triggering mechanism at the body temperature for effective treatments.https://doi.org/10.1038/s41598-022-15069-x |
| spellingShingle | Kamonchanok Thananukul Chariya Kaewsaneha Pakorn Opaprakasit Nadia Zine Abdelhamid Elaissari Biodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature Scientific Reports |
| title | Biodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature |
| title_full | Biodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature |
| title_fullStr | Biodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature |
| title_full_unstemmed | Biodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature |
| title_short | Biodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature |
| title_sort | biodegradable porous micro nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature |
| url | https://doi.org/10.1038/s41598-022-15069-x |
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