Comparison Between cANCA and pANCA In Patients with Renal Disease
Background: Renal involvement is immensely include in antineutrophil cytoplasmic autoantibody (ANCA)-associated systemic vasculitis .It is a significant cause of end-stage renal failure. Objective: To comparison between cytoplasmic autoantibodies a cytoplasmic pattern and antineutrophil cytoplas...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2018-10-01
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| Series: | Diyala Journal of Medicine |
| Subjects: | |
| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/155 |
| _version_ | 1827636386696527872 |
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| author | Hiba Abid Al-Hussein Hassan Athraa Zaidan Hassan Hind S. Jasim Nahla G. Abdul-majeed |
| author_facet | Hiba Abid Al-Hussein Hassan Athraa Zaidan Hassan Hind S. Jasim Nahla G. Abdul-majeed |
| author_sort | Hiba Abid Al-Hussein Hassan |
| collection | DOAJ |
| description |
Background: Renal involvement is immensely include in antineutrophil cytoplasmic autoantibody (ANCA)-associated systemic vasculitis .It is a significant cause of end-stage renal failure.
Objective: To comparison between cytoplasmic autoantibodies a cytoplasmic pattern and antineutrophil cytoplasmic autoantibodies a perinuclear pattern in patients with renal disease .
Patients and Methods: Prospective study reports presenting serological , hematological and biochemical investigations of 44 new patients diagnosed in teaching laboratories of Baghdad hospital from March 2015 to June 2016. All studied groups tested for hemaglobin (Hb), White blood cells (WBC), serum blood urea, Serum blood creatinine, c-reactive protein in addition to antineutrophil cytoplasmic autoantibodies a perinuclear pattern (p-ANCA) and antineutrophil cytoplasmic autoantibodies a cytoplasmic pattern (c-ANCA) detected by enzyme linked immunosorbent assay technique .
Results: All patients with renal disease had antineutrophil cytoplasmic autoantibody a cytoplasmic pattern negative whereas (27.3%) of those patients had positive antineutrophil cytoplasmic autoantibody a perinuclear pattern. Patients with age group range between (20-29) years showed (18.2%) pANCA positive results which mainly involved in female. Clinically evident systemic lupus erythematosus was present in 6 of the 12 patients with positive pANCA .
Conclusion: Serum anti-neutrophil cytoplasmic antibody measurement should not be used alone in the diagnosis of ANCA-associated disease, whereas pANCA is more convincing in the diagnosis than cANCA.
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| first_indexed | 2024-03-09T15:42:13Z |
| format | Article |
| id | doaj.art-cac2b8939ac14141953d46bc7db4b7c7 |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:42:13Z |
| publishDate | 2018-10-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-cac2b8939ac14141953d46bc7db4b7c72023-11-24T23:24:37ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822018-10-01122Comparison Between cANCA and pANCA In Patients with Renal DiseaseHiba Abid Al-Hussein HassanAthraa Zaidan HassanHind S. JasimNahla G. Abdul-majeed Background: Renal involvement is immensely include in antineutrophil cytoplasmic autoantibody (ANCA)-associated systemic vasculitis .It is a significant cause of end-stage renal failure. Objective: To comparison between cytoplasmic autoantibodies a cytoplasmic pattern and antineutrophil cytoplasmic autoantibodies a perinuclear pattern in patients with renal disease . Patients and Methods: Prospective study reports presenting serological , hematological and biochemical investigations of 44 new patients diagnosed in teaching laboratories of Baghdad hospital from March 2015 to June 2016. All studied groups tested for hemaglobin (Hb), White blood cells (WBC), serum blood urea, Serum blood creatinine, c-reactive protein in addition to antineutrophil cytoplasmic autoantibodies a perinuclear pattern (p-ANCA) and antineutrophil cytoplasmic autoantibodies a cytoplasmic pattern (c-ANCA) detected by enzyme linked immunosorbent assay technique . Results: All patients with renal disease had antineutrophil cytoplasmic autoantibody a cytoplasmic pattern negative whereas (27.3%) of those patients had positive antineutrophil cytoplasmic autoantibody a perinuclear pattern. Patients with age group range between (20-29) years showed (18.2%) pANCA positive results which mainly involved in female. Clinically evident systemic lupus erythematosus was present in 6 of the 12 patients with positive pANCA . Conclusion: Serum anti-neutrophil cytoplasmic antibody measurement should not be used alone in the diagnosis of ANCA-associated disease, whereas pANCA is more convincing in the diagnosis than cANCA. http://djm.uodiyala.edu.iq/index.php/djm/article/view/155Antineutrophil cytoplasmic autoantibody, renal disease; enzyme linked immunosorbent assay. |
| spellingShingle | Hiba Abid Al-Hussein Hassan Athraa Zaidan Hassan Hind S. Jasim Nahla G. Abdul-majeed Comparison Between cANCA and pANCA In Patients with Renal Disease Diyala Journal of Medicine Antineutrophil cytoplasmic autoantibody, renal disease; enzyme linked immunosorbent assay. |
| title | Comparison Between cANCA and pANCA In Patients with Renal Disease |
| title_full | Comparison Between cANCA and pANCA In Patients with Renal Disease |
| title_fullStr | Comparison Between cANCA and pANCA In Patients with Renal Disease |
| title_full_unstemmed | Comparison Between cANCA and pANCA In Patients with Renal Disease |
| title_short | Comparison Between cANCA and pANCA In Patients with Renal Disease |
| title_sort | comparison between canca and panca in patients with renal disease |
| topic | Antineutrophil cytoplasmic autoantibody, renal disease; enzyme linked immunosorbent assay. |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/155 |
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