Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders
Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by different levels of repetitive and stereotypic behavior as well as deficits in social interaction and communication. In this current study, we explored the changes in cerebral neural activities in ASD. The purpose of this st...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.768219/full |
| _version_ | 1818985774495825920 |
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| author | Hai-Chen Zhao Rui Lv Guang-Yu Zhang Le-Min He Xiao-Tao Cai Qiang Sun Chun-Yan Yan Xiang-Yuan Bao Xin-Yue Lv Bin Fu |
| author_facet | Hai-Chen Zhao Rui Lv Guang-Yu Zhang Le-Min He Xiao-Tao Cai Qiang Sun Chun-Yan Yan Xiang-Yuan Bao Xin-Yue Lv Bin Fu |
| author_sort | Hai-Chen Zhao |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by different levels of repetitive and stereotypic behavior as well as deficits in social interaction and communication. In this current study, we explored the changes in cerebral neural activities in ASD. The purpose of this study is to investigate whether there exists a dysfunction of interactive information processing between the prefrontal cortex and posterior brain regions in ASD. We investigated the atypical connectivity and information flow between the prefrontal cortex and posterior brain regions in ASD utilizing the entropy connectivity (a kind of directional connectivity) method. Eighty-nine patients with ASD and 94 typical developing (TD) teenagers participated in this study. Two-sample t-tests revealed weakened interactive entropy connectivity between the prefrontal cortex and posterior brain regions. This result indicates that there exists interactive prefrontal-posterior underconnectivity in ASD, and this disorder might lead to less prior knowledge being used and updated. Our proposals highlighted that aforementioned atypical change might accelerate the deoptimization of brain networks in ASD. |
| first_indexed | 2024-12-20T18:40:15Z |
| format | Article |
| id | doaj.art-cac43efddda94a07bf11b10626e19cf3 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-20T18:40:15Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-cac43efddda94a07bf11b10626e19cf32022-12-21T19:29:49ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-01-011510.3389/fnins.2021.768219768219Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum DisordersHai-Chen ZhaoRui LvGuang-Yu ZhangLe-Min HeXiao-Tao CaiQiang SunChun-Yan YanXiang-Yuan BaoXin-Yue LvBin FuAutism spectrum disorder (ASD) is a heterogeneous disorder characterized by different levels of repetitive and stereotypic behavior as well as deficits in social interaction and communication. In this current study, we explored the changes in cerebral neural activities in ASD. The purpose of this study is to investigate whether there exists a dysfunction of interactive information processing between the prefrontal cortex and posterior brain regions in ASD. We investigated the atypical connectivity and information flow between the prefrontal cortex and posterior brain regions in ASD utilizing the entropy connectivity (a kind of directional connectivity) method. Eighty-nine patients with ASD and 94 typical developing (TD) teenagers participated in this study. Two-sample t-tests revealed weakened interactive entropy connectivity between the prefrontal cortex and posterior brain regions. This result indicates that there exists interactive prefrontal-posterior underconnectivity in ASD, and this disorder might lead to less prior knowledge being used and updated. Our proposals highlighted that aforementioned atypical change might accelerate the deoptimization of brain networks in ASD.https://www.frontiersin.org/articles/10.3389/fnins.2021.768219/fullautism spectrum disordersentropy connectivitypredictive coding theoryinformation processingrest-state fMRI |
| spellingShingle | Hai-Chen Zhao Rui Lv Guang-Yu Zhang Le-Min He Xiao-Tao Cai Qiang Sun Chun-Yan Yan Xiang-Yuan Bao Xin-Yue Lv Bin Fu Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders Frontiers in Neuroscience autism spectrum disorders entropy connectivity predictive coding theory information processing rest-state fMRI |
| title | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
| title_full | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
| title_fullStr | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
| title_full_unstemmed | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
| title_short | Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders |
| title_sort | alterations of prefrontal posterior information processing patterns in autism spectrum disorders |
| topic | autism spectrum disorders entropy connectivity predictive coding theory information processing rest-state fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.768219/full |
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