The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy
AimsTo evaluate the degree of coronary microvascular dysfunction (CMD) in dilated cardiomyopathy (DCM) patients by cardiac magnetic resonance (CMR) first-pass perfusion parameters and to examine the correlation between myocardial perfusion and left ventricle reverse remodelling (LVRR).MethodsIn this...
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| Format: | Article |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1301509/full |
| _version_ | 1797405199894052864 |
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| author | Ao Kan Yinping Leng Shuhao Li Fang Lin Qimin Fang Xinwei Tao Mengyao Hu Lianggeng Gong |
| author_facet | Ao Kan Yinping Leng Shuhao Li Fang Lin Qimin Fang Xinwei Tao Mengyao Hu Lianggeng Gong |
| author_sort | Ao Kan |
| collection | DOAJ |
| description | AimsTo evaluate the degree of coronary microvascular dysfunction (CMD) in dilated cardiomyopathy (DCM) patients by cardiac magnetic resonance (CMR) first-pass perfusion parameters and to examine the correlation between myocardial perfusion and left ventricle reverse remodelling (LVRR).MethodsIn this study, 94 DCM patients and 35 healthy controls matched for age and sex were included. Myocardial perfusion parameters, including upslope, time to maximum signal intensity (Timemax), maximum signal intensity (SImax), baseline signal intensity (SIbaseline), and the difference between maximum and baseline signal intensity (SImax−baseline) were measured. Additionally, left ventricular (LV) structure, function parameters, and late gadolinium enhancement (LGE) were also recorded. The parameters were compared between healthy controls and DCM patients. Univariable and multivariable logistic regression analyses were used to determine the predictors of LVRR.ResultsWith a median follow-up period of 12 months [interquartile range (IQR), 8–13], 41 DCM patients (44%) achieved LVRR. Compared with healthy controls, DCM patients presented CMD with reduced upslope, SIbaseline, and increased Timemax (all p < 0.01). Timemax, SImax, and SImax−baseline were further decreased in LVRR than non-LVRR group (Timemax: 60.35 [IQR, 51.46–74.71] vs. 72.41 [IQR, 59.68–97.70], p = 0.017; SImax: 723.52 [IQR, 209.76–909.27] vs. 810.92 [IQR, 581.30–996.89], p = 0.049; SImax−baseline: 462.99 [IQR, 152.25–580.43] vs. 551.13 [IQR, 402.57–675.36], p = 0.038). In the analysis of multivariate logistic regression, Timemax [odds ratio (OR) 0.98; 95% confidence interval (CI) 0.95–1.00; p = 0.032)], heart rate (OR 1.04; 95% CI 1.01–1.08; p = 0.029), LV remodelling index (OR 1.73; 95% CI 1.06–3.00; p = 0.038) and LGE extent (OR 0.85; 95% CI 0.73–0.96; p = 0.021) were independent predictors of LVRR.ConclusionsCMD could be found in DCM patients and was more impaired in patients with non-LVRR than LVRR patients. Timemax at baseline was an independent predictor of LVRR in DCM. |
| first_indexed | 2024-03-09T03:06:23Z |
| format | Article |
| id | doaj.art-cac6ca8f3c714b01a40e0fffd3628d63 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-09T03:06:23Z |
| publishDate | 2023-12-01 |
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| spelling | doaj.art-cac6ca8f3c714b01a40e0fffd3628d632023-12-04T06:57:03ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-12-011010.3389/fcvm.2023.13015091301509The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathyAo Kan0Yinping Leng1Shuhao Li2Fang Lin3Qimin Fang4Xinwei Tao5Mengyao Hu6Lianggeng Gong7Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Medical, Bayer Healthcare, Shanghai, ChinaDepartment of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaAimsTo evaluate the degree of coronary microvascular dysfunction (CMD) in dilated cardiomyopathy (DCM) patients by cardiac magnetic resonance (CMR) first-pass perfusion parameters and to examine the correlation between myocardial perfusion and left ventricle reverse remodelling (LVRR).MethodsIn this study, 94 DCM patients and 35 healthy controls matched for age and sex were included. Myocardial perfusion parameters, including upslope, time to maximum signal intensity (Timemax), maximum signal intensity (SImax), baseline signal intensity (SIbaseline), and the difference between maximum and baseline signal intensity (SImax−baseline) were measured. Additionally, left ventricular (LV) structure, function parameters, and late gadolinium enhancement (LGE) were also recorded. The parameters were compared between healthy controls and DCM patients. Univariable and multivariable logistic regression analyses were used to determine the predictors of LVRR.ResultsWith a median follow-up period of 12 months [interquartile range (IQR), 8–13], 41 DCM patients (44%) achieved LVRR. Compared with healthy controls, DCM patients presented CMD with reduced upslope, SIbaseline, and increased Timemax (all p < 0.01). Timemax, SImax, and SImax−baseline were further decreased in LVRR than non-LVRR group (Timemax: 60.35 [IQR, 51.46–74.71] vs. 72.41 [IQR, 59.68–97.70], p = 0.017; SImax: 723.52 [IQR, 209.76–909.27] vs. 810.92 [IQR, 581.30–996.89], p = 0.049; SImax−baseline: 462.99 [IQR, 152.25–580.43] vs. 551.13 [IQR, 402.57–675.36], p = 0.038). In the analysis of multivariate logistic regression, Timemax [odds ratio (OR) 0.98; 95% confidence interval (CI) 0.95–1.00; p = 0.032)], heart rate (OR 1.04; 95% CI 1.01–1.08; p = 0.029), LV remodelling index (OR 1.73; 95% CI 1.06–3.00; p = 0.038) and LGE extent (OR 0.85; 95% CI 0.73–0.96; p = 0.021) were independent predictors of LVRR.ConclusionsCMD could be found in DCM patients and was more impaired in patients with non-LVRR than LVRR patients. Timemax at baseline was an independent predictor of LVRR in DCM.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1301509/fullcoronary microvascular dysfunctionmyocardial perfusioncardiac magnetic resonancedilated cardiomyopathyleft ventricular reverse remodelling |
| spellingShingle | Ao Kan Yinping Leng Shuhao Li Fang Lin Qimin Fang Xinwei Tao Mengyao Hu Lianggeng Gong The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy Frontiers in Cardiovascular Medicine coronary microvascular dysfunction myocardial perfusion cardiac magnetic resonance dilated cardiomyopathy left ventricular reverse remodelling |
| title | The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy |
| title_full | The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy |
| title_fullStr | The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy |
| title_full_unstemmed | The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy |
| title_short | The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy |
| title_sort | predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy |
| topic | coronary microvascular dysfunction myocardial perfusion cardiac magnetic resonance dilated cardiomyopathy left ventricular reverse remodelling |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1301509/full |
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