The Estimate of Parental Quality of Life Loss Due to Respiratory Syncytial Virus (RSV) Hospitalization
Background: Respiratory syncytial virus (RSV) is one of the leading causes of pediatric hospitalizations, mainly in children under 2 years of age. Hospitalization affects the caregivers’ quality of life (QoL). We assessed the caregivers’ QoL during RSV-confirmed hospitalizations of children under 2...
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MDPI AG
2023-09-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/11/4/126 |
| _version_ | 1827575077673107456 |
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| author | August Wrotek Oliwia Wrotek Teresa Jackowska |
| author_facet | August Wrotek Oliwia Wrotek Teresa Jackowska |
| author_sort | August Wrotek |
| collection | DOAJ |
| description | Background: Respiratory syncytial virus (RSV) is one of the leading causes of pediatric hospitalizations, mainly in children under 2 years of age. Hospitalization affects the caregivers’ quality of life (QoL). We assessed the caregivers’ QoL during RSV-confirmed hospitalizations of children under 2 years old, identified the most affected QoL dimensions and calculated utilities focusing on the assessment methods and potential confounders. Methods: The caregivers filled out the EQ-5D questionnaire, consisting of a descriptive system (assessing 5 QoL dimensions) and a visual analog scale (EQ VAS). Utility, utility loss and quality-adjusted life years (QALY) loss were calculated, and a concordance between the two systems was assessed. Results: A disturbance in any of the five assessed dimensions was reported by 42% (55 out of 132) of the caregivers, mostly anxiety/depression (37%) and pain/discomfort (17%). The utilities varied between 0.17 and 1 in the descriptive system and 0.33–1 (median 0.86) in the EQ VAS, with a utility loss of 0.14 (IQR: 0.1–0.2). The calculated QALY loss reached a median of 2.45 × 10<sup>−3</sup> (IQR: 1.37 × 10<sup>−3</sup>–4.56 × 10<sup>−3</sup>) and was not influenced by the patient’s age or the final clinical diagnosis (QALY loss for bronchiolitis: 2.74 × 10<sup>−3</sup>, pneumonia: 1.84 × 10<sup>−3</sup>, bronchitis: 1.78 × 10<sup>−3</sup>, differences statistically insignificant). Only a moderate concordance between the descriptive system and the EQ VAS was seen (Spearman’s rank correlation coefficient = 0.437, <i>p</i> < 0.05), with the latter revealing a higher degree of QoL disturbances. Conclusions: RSV hospitalization influences parental QoL significantly, and anxiety/depression is the most commonly reported issue. Utility impairment scores depend on the assessment method but not on the patient’s age or final diagnosis. Thus, the impact of RSV on caregivers’ QoL cannot be underestimated. |
| first_indexed | 2024-03-08T20:51:05Z |
| format | Article |
| id | doaj.art-cac7d18ebfa2457c96dbe7d5a0054e81 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-08T20:51:05Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-cac7d18ebfa2457c96dbe7d5a0054e812023-12-22T14:03:28ZengMDPI AGDiseases2079-97212023-09-0111412610.3390/diseases11040126The Estimate of Parental Quality of Life Loss Due to Respiratory Syncytial Virus (RSV) HospitalizationAugust Wrotek0Oliwia Wrotek1Teresa Jackowska2Department of Pediatrics, Centre of Postgraduate Medical Education, Marymoncka 99/103, 01-813 Warsaw, PolandStudent Research Group, Bielanski Hospital, Cegłowska 80, 01-809 Warsaw, PolandDepartment of Pediatrics, Centre of Postgraduate Medical Education, Marymoncka 99/103, 01-813 Warsaw, PolandBackground: Respiratory syncytial virus (RSV) is one of the leading causes of pediatric hospitalizations, mainly in children under 2 years of age. Hospitalization affects the caregivers’ quality of life (QoL). We assessed the caregivers’ QoL during RSV-confirmed hospitalizations of children under 2 years old, identified the most affected QoL dimensions and calculated utilities focusing on the assessment methods and potential confounders. Methods: The caregivers filled out the EQ-5D questionnaire, consisting of a descriptive system (assessing 5 QoL dimensions) and a visual analog scale (EQ VAS). Utility, utility loss and quality-adjusted life years (QALY) loss were calculated, and a concordance between the two systems was assessed. Results: A disturbance in any of the five assessed dimensions was reported by 42% (55 out of 132) of the caregivers, mostly anxiety/depression (37%) and pain/discomfort (17%). The utilities varied between 0.17 and 1 in the descriptive system and 0.33–1 (median 0.86) in the EQ VAS, with a utility loss of 0.14 (IQR: 0.1–0.2). The calculated QALY loss reached a median of 2.45 × 10<sup>−3</sup> (IQR: 1.37 × 10<sup>−3</sup>–4.56 × 10<sup>−3</sup>) and was not influenced by the patient’s age or the final clinical diagnosis (QALY loss for bronchiolitis: 2.74 × 10<sup>−3</sup>, pneumonia: 1.84 × 10<sup>−3</sup>, bronchitis: 1.78 × 10<sup>−3</sup>, differences statistically insignificant). Only a moderate concordance between the descriptive system and the EQ VAS was seen (Spearman’s rank correlation coefficient = 0.437, <i>p</i> < 0.05), with the latter revealing a higher degree of QoL disturbances. Conclusions: RSV hospitalization influences parental QoL significantly, and anxiety/depression is the most commonly reported issue. Utility impairment scores depend on the assessment method but not on the patient’s age or final diagnosis. Thus, the impact of RSV on caregivers’ QoL cannot be underestimated.https://www.mdpi.com/2079-9721/11/4/126respiratory syncytial virusbronchiolitispneumoniacaregiverinfantquality-adjusted life year |
| spellingShingle | August Wrotek Oliwia Wrotek Teresa Jackowska The Estimate of Parental Quality of Life Loss Due to Respiratory Syncytial Virus (RSV) Hospitalization Diseases respiratory syncytial virus bronchiolitis pneumonia caregiver infant quality-adjusted life year |
| title | The Estimate of Parental Quality of Life Loss Due to Respiratory Syncytial Virus (RSV) Hospitalization |
| title_full | The Estimate of Parental Quality of Life Loss Due to Respiratory Syncytial Virus (RSV) Hospitalization |
| title_fullStr | The Estimate of Parental Quality of Life Loss Due to Respiratory Syncytial Virus (RSV) Hospitalization |
| title_full_unstemmed | The Estimate of Parental Quality of Life Loss Due to Respiratory Syncytial Virus (RSV) Hospitalization |
| title_short | The Estimate of Parental Quality of Life Loss Due to Respiratory Syncytial Virus (RSV) Hospitalization |
| title_sort | estimate of parental quality of life loss due to respiratory syncytial virus rsv hospitalization |
| topic | respiratory syncytial virus bronchiolitis pneumonia caregiver infant quality-adjusted life year |
| url | https://www.mdpi.com/2079-9721/11/4/126 |
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