Pharmacodynamics of Ceftibuten: An Assessment of an Oral Cephalosporin against Enterobacterales in a Neutropenic Murine Thigh Model

Pharmacodynamics of Ceftibuten: An Assessment of an Oral Cephalosporin against Enterobacterales in a Neutropenic Murine Thigh Model

Efforts to develop and pair novel oral β-lactamase inhibitors with existing β-lactam agents to treat extended spectrum β-lactamase (ESBL) and carbapenemase-producing Enterobacterales are gaining ground. Ceftibuten is an oral third-generation cephalosporin capable of achieving high urine concentratio...

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Bibliographic Details
Main Authors:	Maxwell J. Lasko, Tomefa E. Asempa, David P. Nicolau
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Antibiotics
Subjects:	pharmacokinetics pharmacodynamics Gram-negative beta-lactamase
Online Access:	https://www.mdpi.com/2079-6382/10/2/201

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