Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review
The current understanding of atopic dermatitis (AD) seems to be extending beyond a skin-confined condition frequently associated with allergic comorbidities, as in a number of epidemiological studies, the prevalence rate of a range of illnesses has been determined to be greater in patients with AD,...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/1194 |
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| author | Weronika Zysk Alicja Mesjasz Magdalena Trzeciak Andrea Horvath Katarzyna Plata-Nazar |
| author_facet | Weronika Zysk Alicja Mesjasz Magdalena Trzeciak Andrea Horvath Katarzyna Plata-Nazar |
| author_sort | Weronika Zysk |
| collection | DOAJ |
| description | The current understanding of atopic dermatitis (AD) seems to be extending beyond a skin-confined condition frequently associated with allergic comorbidities, as in a number of epidemiological studies, the prevalence rate of a range of illnesses has been determined to be greater in patients with AD, or inversely. In most cases, the reasons for this are vague. A subset of these conditions are gastrointestinal disorders, including food sensitization (FS) and food allergy (FA), eosinophilic esophagitis (EoE) (it is of mixed background, both IgE-dependent and independent), food protein-induced enterocolitis syndrome (FPIES) (it exemplifies an IgE-independent food allergy), Crohn’s disease (CD), colitis ulcerosa (CU), celiac disease, irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD). In this review, we performed a comprehensive search of the literature using the PubMed database. We addressed the epidemiology of the increased co-occurrence of these diseases with AD and discussed potential causes for this subject. Multiple gastroenterological comorbidities appear to be more common in patients with AD, according to our review. The mechanisms that underlie this phenomenon are largely unknown, highlighting the need for further study in this field. |
| first_indexed | 2024-03-08T09:53:14Z |
| format | Article |
| id | doaj.art-cac89189232b4aae88ab064dbbd8ee60 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:53:14Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cac89189232b4aae88ab064dbbd8ee602024-01-29T13:58:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-01252119410.3390/ijms25021194Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative ReviewWeronika Zysk0Alicja Mesjasz1Magdalena Trzeciak2Andrea Horvath3Katarzyna Plata-Nazar4Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, PolandDermatological Students Scientific Association, Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, PolandDepartment of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, PolandDepartment of Paedistrics, Medical University of Warsaw, Żwirki I Wigury 63a, 02-091 Warszawa, PolandDepartment of Paediatrics, Gastroenterology, Allergology and Paediatric Nutrition, Faculty of Medicine, Medical University of Gdańsk, Nowe Ogrody 1-6, 80-803 Gdańsk, PolandThe current understanding of atopic dermatitis (AD) seems to be extending beyond a skin-confined condition frequently associated with allergic comorbidities, as in a number of epidemiological studies, the prevalence rate of a range of illnesses has been determined to be greater in patients with AD, or inversely. In most cases, the reasons for this are vague. A subset of these conditions are gastrointestinal disorders, including food sensitization (FS) and food allergy (FA), eosinophilic esophagitis (EoE) (it is of mixed background, both IgE-dependent and independent), food protein-induced enterocolitis syndrome (FPIES) (it exemplifies an IgE-independent food allergy), Crohn’s disease (CD), colitis ulcerosa (CU), celiac disease, irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD). In this review, we performed a comprehensive search of the literature using the PubMed database. We addressed the epidemiology of the increased co-occurrence of these diseases with AD and discussed potential causes for this subject. Multiple gastroenterological comorbidities appear to be more common in patients with AD, according to our review. The mechanisms that underlie this phenomenon are largely unknown, highlighting the need for further study in this field.https://www.mdpi.com/1422-0067/25/2/1194atopic dermatitisgastrointestinal diseasecomorbidity |
| spellingShingle | Weronika Zysk Alicja Mesjasz Magdalena Trzeciak Andrea Horvath Katarzyna Plata-Nazar Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review International Journal of Molecular Sciences atopic dermatitis gastrointestinal disease comorbidity |
| title | Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review |
| title_full | Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review |
| title_fullStr | Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review |
| title_full_unstemmed | Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review |
| title_short | Gastrointestinal Comorbidities Associated with Atopic Dermatitis—A Narrative Review |
| title_sort | gastrointestinal comorbidities associated with atopic dermatitis a narrative review |
| topic | atopic dermatitis gastrointestinal disease comorbidity |
| url | https://www.mdpi.com/1422-0067/25/2/1194 |
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