Moringa-Fu brick tea extract attenuated high-fat diet-induced obesity via modulating bile acid metabolism and gut microbiota in rats
Obesity is regarded to be correlated with disorders of lipid metabolism, bile acid metabolism and dysbiosis of the gut microbiota. Moringa-Fu brick tea (MFBT), a functional food, has a significant anti-obesity effect. However, the effectiveness and mechanisms of MFBT in preventing obesity require fu...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623003663 |
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| author | Jian Ou-yang Xiu-ping Li Chang-wei Liu Jie Ou-yang Jing-yi Tang Qi Liu Jian-an Huang Zhonghua Liu |
| author_facet | Jian Ou-yang Xiu-ping Li Chang-wei Liu Jie Ou-yang Jing-yi Tang Qi Liu Jian-an Huang Zhonghua Liu |
| author_sort | Jian Ou-yang |
| collection | DOAJ |
| description | Obesity is regarded to be correlated with disorders of lipid metabolism, bile acid metabolism and dysbiosis of the gut microbiota. Moringa-Fu brick tea (MFBT), a functional food, has a significant anti-obesity effect. However, the effectiveness and mechanisms of MFBT in preventing obesity require further investigation. Here, our results show that moringa-Fu brick tea extract (MFTE) displays anti-obesity effects by reducing high-fat diet-induced weight gain and adipose tissue accumulation in rats, and attenuating visceral adiposity index, oxidative stress and inflammation. In addition, MFTE could regulate gut microbiota diversity, reduce the relative abundance of microbioa associated with bile salt hydrolase (BSH) activity, such as Blautia, Ruminococcaceae, Coprococcus and Roseburia. Moreover, MFTE could improve the expression of the main rate-limiting enzymes CYP7A1 and CYP27A1 in the process of bile acid synthesis, downregulate the expression of intestinal FXR protein, promote the serum bile acid level, and reduce the accumulation of cholesterol in serum and liver. Taken together, these results suggested that MFBT could serve as a functional food for prevention of obesity and hyperlipidemia in association with regulating bile acid metabolism and gut microbiota. |
| first_indexed | 2024-03-11T18:29:18Z |
| format | Article |
| id | doaj.art-cacb1048b5854b6899110b27bbcc1fb3 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-11T18:29:18Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-cacb1048b5854b6899110b27bbcc1fb32023-10-13T13:52:48ZengElsevierJournal of Functional Foods1756-46462023-10-01109105766Moringa-Fu brick tea extract attenuated high-fat diet-induced obesity via modulating bile acid metabolism and gut microbiota in ratsJian Ou-yang0Xiu-ping Li1Chang-wei Liu2Jie Ou-yang3Jing-yi Tang4Qi Liu5Jian-an Huang6Zhonghua Liu7Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaKey Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaKey Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaKey Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaKey Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaKey Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaKey Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China; Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural Affairs of China, Hunan Agricultural University, 410128, Changsha, China; Corresponding authors at: Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China.Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China; Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China; Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural Affairs of China, Hunan Agricultural University, 410128, Changsha, China; Corresponding authors at: Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China.Obesity is regarded to be correlated with disorders of lipid metabolism, bile acid metabolism and dysbiosis of the gut microbiota. Moringa-Fu brick tea (MFBT), a functional food, has a significant anti-obesity effect. However, the effectiveness and mechanisms of MFBT in preventing obesity require further investigation. Here, our results show that moringa-Fu brick tea extract (MFTE) displays anti-obesity effects by reducing high-fat diet-induced weight gain and adipose tissue accumulation in rats, and attenuating visceral adiposity index, oxidative stress and inflammation. In addition, MFTE could regulate gut microbiota diversity, reduce the relative abundance of microbioa associated with bile salt hydrolase (BSH) activity, such as Blautia, Ruminococcaceae, Coprococcus and Roseburia. Moreover, MFTE could improve the expression of the main rate-limiting enzymes CYP7A1 and CYP27A1 in the process of bile acid synthesis, downregulate the expression of intestinal FXR protein, promote the serum bile acid level, and reduce the accumulation of cholesterol in serum and liver. Taken together, these results suggested that MFBT could serve as a functional food for prevention of obesity and hyperlipidemia in association with regulating bile acid metabolism and gut microbiota.http://www.sciencedirect.com/science/article/pii/S1756464623003663Moringa-Fu brick teaHigh-fat dietObesityBile acid metabolismGut microbiota |
| spellingShingle | Jian Ou-yang Xiu-ping Li Chang-wei Liu Jie Ou-yang Jing-yi Tang Qi Liu Jian-an Huang Zhonghua Liu Moringa-Fu brick tea extract attenuated high-fat diet-induced obesity via modulating bile acid metabolism and gut microbiota in rats Journal of Functional Foods Moringa-Fu brick tea High-fat diet Obesity Bile acid metabolism Gut microbiota |
| title | Moringa-Fu brick tea extract attenuated high-fat diet-induced obesity via modulating bile acid metabolism and gut microbiota in rats |
| title_full | Moringa-Fu brick tea extract attenuated high-fat diet-induced obesity via modulating bile acid metabolism and gut microbiota in rats |
| title_fullStr | Moringa-Fu brick tea extract attenuated high-fat diet-induced obesity via modulating bile acid metabolism and gut microbiota in rats |
| title_full_unstemmed | Moringa-Fu brick tea extract attenuated high-fat diet-induced obesity via modulating bile acid metabolism and gut microbiota in rats |
| title_short | Moringa-Fu brick tea extract attenuated high-fat diet-induced obesity via modulating bile acid metabolism and gut microbiota in rats |
| title_sort | moringa fu brick tea extract attenuated high fat diet induced obesity via modulating bile acid metabolism and gut microbiota in rats |
| topic | Moringa-Fu brick tea High-fat diet Obesity Bile acid metabolism Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623003663 |
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