Dyslipidaemia Is Associated with Severe Disease Activity and Poor Prognosis in Ulcerative Colitis: A Retrospective Cohort Study in China
Background: Clinical data on the correlation of dyslipidaemia with the long-term outcomes of ulcerative colitis (UC) are limited. This study aimed to evaluate the impact of lipid levels on disease activity and prognosis in UC. Methods: The retrospective data of UC patients who had detailed lipid pro...
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MDPI AG
2022-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/15/3040 |
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| author | Zhaoshi Liu Hao Tang Haozheng Liang Xiaoyin Bai Huimin Zhang Hong Yang Hongying Wang Li Wang Jiaming Qian |
| author_facet | Zhaoshi Liu Hao Tang Haozheng Liang Xiaoyin Bai Huimin Zhang Hong Yang Hongying Wang Li Wang Jiaming Qian |
| author_sort | Zhaoshi Liu |
| collection | DOAJ |
| description | Background: Clinical data on the correlation of dyslipidaemia with the long-term outcomes of ulcerative colitis (UC) are limited. This study aimed to evaluate the impact of lipid levels on disease activity and prognosis in UC. Methods: The retrospective data of UC patients who had detailed lipid profiles were collected from January 2003 to September 2020. All patients were followed-up to 30 September 2021. The long-term outcomes were UC-related surgery and tumorigenesis. Results: In total, 497 patients were included in the analysis. Compared to patients with normal lipid levels, those with dyslipidaemia commonly presented with more serious disease activity. Low high-density lipoprotein cholesterol (<i>p</i> < 0.05) levels were associated with higher risks of severe disease activity in UC. Regarding the long-term outcomes, patients with persistent dyslipidaemia were at higher risks of UC-related surgery (HR: 3.27, 95% CI: 1.86–5.75, <i>p</i> < 0.001) and tumorigenesis (HR: 7.92, 95% CI: 3.97–15.78, <i>p</i> < 0.001) and had shorter surgery- and tumour-free survival (<i>p</i> < 0.001) than patients with transient dyslipidaemia and normal lipid levels. Low levels of high-density lipoprotein cholesterol (<i>p</i> < 0.001) and apolipoprotein A1 (<i>p</i> < 0.05) were associated with higher risks of surgery and tumorigenesis. Conclusion: Persistent dyslipidaemia was associated with a higher risk of serious disease activity and worse long-term outcomes among patients with UC. Lipid patterns should be assessed to improve the management of high-risk patients with UC in the early phase. |
| first_indexed | 2024-03-09T12:19:14Z |
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| id | doaj.art-cacb295c2b434feda76ae33a669f269f |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T12:19:14Z |
| publishDate | 2022-07-01 |
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| series | Nutrients |
| spelling | doaj.art-cacb295c2b434feda76ae33a669f269f2023-11-30T22:43:35ZengMDPI AGNutrients2072-66432022-07-011415304010.3390/nu14153040Dyslipidaemia Is Associated with Severe Disease Activity and Poor Prognosis in Ulcerative Colitis: A Retrospective Cohort Study in ChinaZhaoshi Liu0Hao Tang1Haozheng Liang2Xiaoyin Bai3Huimin Zhang4Hong Yang5Hongying Wang6Li Wang7Jiaming Qian8Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaBackground: Clinical data on the correlation of dyslipidaemia with the long-term outcomes of ulcerative colitis (UC) are limited. This study aimed to evaluate the impact of lipid levels on disease activity and prognosis in UC. Methods: The retrospective data of UC patients who had detailed lipid profiles were collected from January 2003 to September 2020. All patients were followed-up to 30 September 2021. The long-term outcomes were UC-related surgery and tumorigenesis. Results: In total, 497 patients were included in the analysis. Compared to patients with normal lipid levels, those with dyslipidaemia commonly presented with more serious disease activity. Low high-density lipoprotein cholesterol (<i>p</i> < 0.05) levels were associated with higher risks of severe disease activity in UC. Regarding the long-term outcomes, patients with persistent dyslipidaemia were at higher risks of UC-related surgery (HR: 3.27, 95% CI: 1.86–5.75, <i>p</i> < 0.001) and tumorigenesis (HR: 7.92, 95% CI: 3.97–15.78, <i>p</i> < 0.001) and had shorter surgery- and tumour-free survival (<i>p</i> < 0.001) than patients with transient dyslipidaemia and normal lipid levels. Low levels of high-density lipoprotein cholesterol (<i>p</i> < 0.001) and apolipoprotein A1 (<i>p</i> < 0.05) were associated with higher risks of surgery and tumorigenesis. Conclusion: Persistent dyslipidaemia was associated with a higher risk of serious disease activity and worse long-term outcomes among patients with UC. Lipid patterns should be assessed to improve the management of high-risk patients with UC in the early phase.https://www.mdpi.com/2072-6643/14/15/3040ulcerative colitisabnormal serum lipidlipid profilesinflammationdisease severitysurgery |
| spellingShingle | Zhaoshi Liu Hao Tang Haozheng Liang Xiaoyin Bai Huimin Zhang Hong Yang Hongying Wang Li Wang Jiaming Qian Dyslipidaemia Is Associated with Severe Disease Activity and Poor Prognosis in Ulcerative Colitis: A Retrospective Cohort Study in China Nutrients ulcerative colitis abnormal serum lipid lipid profiles inflammation disease severity surgery |
| title | Dyslipidaemia Is Associated with Severe Disease Activity and Poor Prognosis in Ulcerative Colitis: A Retrospective Cohort Study in China |
| title_full | Dyslipidaemia Is Associated with Severe Disease Activity and Poor Prognosis in Ulcerative Colitis: A Retrospective Cohort Study in China |
| title_fullStr | Dyslipidaemia Is Associated with Severe Disease Activity and Poor Prognosis in Ulcerative Colitis: A Retrospective Cohort Study in China |
| title_full_unstemmed | Dyslipidaemia Is Associated with Severe Disease Activity and Poor Prognosis in Ulcerative Colitis: A Retrospective Cohort Study in China |
| title_short | Dyslipidaemia Is Associated with Severe Disease Activity and Poor Prognosis in Ulcerative Colitis: A Retrospective Cohort Study in China |
| title_sort | dyslipidaemia is associated with severe disease activity and poor prognosis in ulcerative colitis a retrospective cohort study in china |
| topic | ulcerative colitis abnormal serum lipid lipid profiles inflammation disease severity surgery |
| url | https://www.mdpi.com/2072-6643/14/15/3040 |
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