Nonalcoholic steatohepatitis and obesity: influence of key risk factors on the development of obstetric and perinatal complications in pregnant women
The aim of our study is to assess the development of obstetric and perinatal complications in obese pregnant women with non-alcoholic steatohepatitis (NASH) depending on changes in blood lipid spectrum and body mass index (BMI). Materials and methods. We examined 98 pregnant women with non-alcoho...
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2022-07-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/252654/257200 |
| _version_ | 1818488924449800192 |
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| author | L. V. Bahnii S. M. Heriak N. I. Bahnii |
| author_facet | L. V. Bahnii S. M. Heriak N. I. Bahnii |
| author_sort | L. V. Bahnii |
| collection | DOAJ |
| description | The aim of our study is to assess the development of obstetric and perinatal complications in obese pregnant women with non-alcoholic steatohepatitis (NASH) depending on changes in blood lipid spectrum and body mass index (BMI).
Materials and methods. We examined 98 pregnant women with non-alcoholic fatty liver disease (NAFLD) at the stage of NASH in combination with obesity. The control group consisted of 30 healthy pregnant women. All pregnant women with NAFLD and abdominal obesity were divided into 3 groups depending on BMI: Group I – 26 pregnant women with BMI 25.0–29.9 kg/m², Group II – 48 pregnant women with BMI 30.0–34.9 kg/m2, Group III – 24 pregnant women with BMI 35.0–39.9 kg/m2. Correlations of obstetric complications depending on changes in lipid metabolism and BMI were determined.
Results. The analysis of obstetric complications revealed 3.4 times higher risk of early miscarriage in group I, 5.6 times – in group II, 7.5 times – in group III compared the control group (P < 0.05); early gestosis occurred 1.9 times more often in group I, 2.5 times – in group II, 3.3 times – in group III as compared to that in pregnant women of the control group (P < 0.05); the threat of premature birth was found 3.4 times more frequently in group I, 5.6 times – in group II, 7.5 times – in group III as compared with the control group (P < 0.05).
Group I patients developed placental dysfunction with a frequency of 2.3 times, group II – of 4.0 times, and group III – of 6.3 times greater than pregnant women of the control group (P < 0.05), and moderate preeclampsia was diagnosed in overweight pregnant women, as well as in women with grade I and grade II–III obesity 2.3 times, 4.7 times and 5.6 times as often, respectively, as in the control group (P < 0.05). Correlation analysis showed correlations between lipid metabolism indicators and an increase in BMI.
Conclusions. Obese pregnant women with NAFLD at the stage of NASH were found to have significantly more frequent obstetric and perinatal complications as well as lipid profile abnormalities correlating with increased BMI, which may be due to the presence of NASH and functional liver failure. |
| first_indexed | 2024-12-10T16:57:21Z |
| format | Article |
| id | doaj.art-cacccd1266ae4a6f923d647201ce4460 |
| institution | Directory Open Access Journal |
| issn | 2306-4145 2310-1210 |
| language | English |
| last_indexed | 2024-12-10T16:57:21Z |
| publishDate | 2022-07-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj.art-cacccd1266ae4a6f923d647201ce44602022-12-22T01:40:41ZengZaporozhye State Medical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102022-07-0124330130910.14739/2310-1210.2022.3.252654Nonalcoholic steatohepatitis and obesity: influence of key risk factors on the development of obstetric and perinatal complications in pregnant womenL. V. Bahnii0https://orcid.org/0000-0002-4224-0657S. M. Heriak1https://orcid.org/0000-0002-7894-1009N. I. Bahnii2https://orcid.org/0000-0003-1192-149XIvan Horbachevsky Ternopil National Medical University of the Ministry of Health of UkraineIvan Horbachevsky Ternopil National Medical University of the Ministry of Health of UkraineIvan Horbachevsky Ternopil National Medical University of the Ministry of Health of UkraineThe aim of our study is to assess the development of obstetric and perinatal complications in obese pregnant women with non-alcoholic steatohepatitis (NASH) depending on changes in blood lipid spectrum and body mass index (BMI). Materials and methods. We examined 98 pregnant women with non-alcoholic fatty liver disease (NAFLD) at the stage of NASH in combination with obesity. The control group consisted of 30 healthy pregnant women. All pregnant women with NAFLD and abdominal obesity were divided into 3 groups depending on BMI: Group I – 26 pregnant women with BMI 25.0–29.9 kg/m², Group II – 48 pregnant women with BMI 30.0–34.9 kg/m2, Group III – 24 pregnant women with BMI 35.0–39.9 kg/m2. Correlations of obstetric complications depending on changes in lipid metabolism and BMI were determined. Results. The analysis of obstetric complications revealed 3.4 times higher risk of early miscarriage in group I, 5.6 times – in group II, 7.5 times – in group III compared the control group (P < 0.05); early gestosis occurred 1.9 times more often in group I, 2.5 times – in group II, 3.3 times – in group III as compared to that in pregnant women of the control group (P < 0.05); the threat of premature birth was found 3.4 times more frequently in group I, 5.6 times – in group II, 7.5 times – in group III as compared with the control group (P < 0.05). Group I patients developed placental dysfunction with a frequency of 2.3 times, group II – of 4.0 times, and group III – of 6.3 times greater than pregnant women of the control group (P < 0.05), and moderate preeclampsia was diagnosed in overweight pregnant women, as well as in women with grade I and grade II–III obesity 2.3 times, 4.7 times and 5.6 times as often, respectively, as in the control group (P < 0.05). Correlation analysis showed correlations between lipid metabolism indicators and an increase in BMI. Conclusions. Obese pregnant women with NAFLD at the stage of NASH were found to have significantly more frequent obstetric and perinatal complications as well as lipid profile abnormalities correlating with increased BMI, which may be due to the presence of NASH and functional liver failure.http://zmj.zsmu.edu.ua/article/view/252654/257200non-alcoholic steatohepatitisobesitybody mass indexlipid metabolismpregnancy complications |
| spellingShingle | L. V. Bahnii S. M. Heriak N. I. Bahnii Nonalcoholic steatohepatitis and obesity: influence of key risk factors on the development of obstetric and perinatal complications in pregnant women Zaporožskij Medicinskij Žurnal non-alcoholic steatohepatitis obesity body mass index lipid metabolism pregnancy complications |
| title | Nonalcoholic steatohepatitis and obesity: influence of key risk factors on the development of obstetric and perinatal complications in pregnant women |
| title_full | Nonalcoholic steatohepatitis and obesity: influence of key risk factors on the development of obstetric and perinatal complications in pregnant women |
| title_fullStr | Nonalcoholic steatohepatitis and obesity: influence of key risk factors on the development of obstetric and perinatal complications in pregnant women |
| title_full_unstemmed | Nonalcoholic steatohepatitis and obesity: influence of key risk factors on the development of obstetric and perinatal complications in pregnant women |
| title_short | Nonalcoholic steatohepatitis and obesity: influence of key risk factors on the development of obstetric and perinatal complications in pregnant women |
| title_sort | nonalcoholic steatohepatitis and obesity influence of key risk factors on the development of obstetric and perinatal complications in pregnant women |
| topic | non-alcoholic steatohepatitis obesity body mass index lipid metabolism pregnancy complications |
| url | http://zmj.zsmu.edu.ua/article/view/252654/257200 |
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