Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical Stimulation
Stroke leads to serious long-term disability. Electrical epidural cortical stimulation has made significant improvements in stroke rehabilitation therapy. We developed a preliminary wireless implantable passive interface, which consists of a stimulating surface electrode, receiving coil, and single...
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| Language: | English |
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MDPI AG
2017-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/18/2/335 |
| _version_ | 1811207631593799680 |
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| author | Xing Wang Sharjeel A. Chaudhry Wensheng Hou Xiaofeng Jia |
| author_facet | Xing Wang Sharjeel A. Chaudhry Wensheng Hou Xiaofeng Jia |
| author_sort | Xing Wang |
| collection | DOAJ |
| description | Stroke leads to serious long-term disability. Electrical epidural cortical stimulation has made significant improvements in stroke rehabilitation therapy. We developed a preliminary wireless implantable passive interface, which consists of a stimulating surface electrode, receiving coil, and single flexible passive demodulated circuit printed by flexible printed circuit (FPC) technique and output pulse voltage stimulus by inductively coupling an external circuit. The wireless implantable board was implanted in cats’ unilateral epidural space for electrical stimulation of the primary visual cortex (V1) while the evoked responses were recorded on the contralateral V1 using a needle electrode. The wireless implantable board output stable monophasic voltage stimuli. The amplitude of the monophasic voltage output could be adjusted by controlling the voltage of the transmitter circuit within a range of 5–20 V. In acute experiment, cortico-cortical evoked potential (CCEP) response was recorded on the contralateral V1. The amplitude of N2 in CCEP was modulated by adjusting the stimulation intensity of the wireless interface. These results demonstrated that a wireless interface based on a microcoil array can offer a valuable tool for researchers to explore electrical stimulation in research and the dura mater-electrode interface can effectively transmit electrical stimulation. |
| first_indexed | 2024-04-12T04:07:56Z |
| format | Article |
| id | doaj.art-cad1e5752ad74f7195a5a0f16d4bf653 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T04:07:56Z |
| publishDate | 2017-02-01 |
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| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cad1e5752ad74f7195a5a0f16d4bf6532022-12-22T03:48:35ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-02-0118233510.3390/ijms18020335ijms18020335Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical StimulationXing Wang0Sharjeel A. Chaudhry1Wensheng Hou2Xiaofeng Jia3Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, ChinaSchool of Medicine and Health Sciences, George Washington University, Washington, DC 20037, USAKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, ChinaDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USAStroke leads to serious long-term disability. Electrical epidural cortical stimulation has made significant improvements in stroke rehabilitation therapy. We developed a preliminary wireless implantable passive interface, which consists of a stimulating surface electrode, receiving coil, and single flexible passive demodulated circuit printed by flexible printed circuit (FPC) technique and output pulse voltage stimulus by inductively coupling an external circuit. The wireless implantable board was implanted in cats’ unilateral epidural space for electrical stimulation of the primary visual cortex (V1) while the evoked responses were recorded on the contralateral V1 using a needle electrode. The wireless implantable board output stable monophasic voltage stimuli. The amplitude of the monophasic voltage output could be adjusted by controlling the voltage of the transmitter circuit within a range of 5–20 V. In acute experiment, cortico-cortical evoked potential (CCEP) response was recorded on the contralateral V1. The amplitude of N2 in CCEP was modulated by adjusting the stimulation intensity of the wireless interface. These results demonstrated that a wireless interface based on a microcoil array can offer a valuable tool for researchers to explore electrical stimulation in research and the dura mater-electrode interface can effectively transmit electrical stimulation.http://www.mdpi.com/1422-0067/18/2/335strokerehabilitationinductive couplingmicro coilnerve-electrode interfaceepidural cortical stimulation |
| spellingShingle | Xing Wang Sharjeel A. Chaudhry Wensheng Hou Xiaofeng Jia Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical Stimulation International Journal of Molecular Sciences stroke rehabilitation inductive coupling micro coil nerve-electrode interface epidural cortical stimulation |
| title | Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical Stimulation |
| title_full | Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical Stimulation |
| title_fullStr | Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical Stimulation |
| title_full_unstemmed | Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical Stimulation |
| title_short | Developing and Evaluating a Flexible Wireless Microcoil Array Based Integrated Interface for Epidural Cortical Stimulation |
| title_sort | developing and evaluating a flexible wireless microcoil array based integrated interface for epidural cortical stimulation |
| topic | stroke rehabilitation inductive coupling micro coil nerve-electrode interface epidural cortical stimulation |
| url | http://www.mdpi.com/1422-0067/18/2/335 |
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