Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring
Many hospitals face barriers in the implementation of TDM services, this study aimed to evaluate a pharmacist-led TDM service to optimize patients’ outcomes. Adult patients who were administered vancomycin, gentamicin, or amikacin were included. The pre-phase included a retrospective asses...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
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| Series: | Pharmacy |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2226-4787/7/1/20 |
| _version_ | 1811187477073887232 |
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| author | Abrar F Alhameed Sara Al Khansa Hani Hasan Sherine Ismail Mohammed Aseeri |
| author_facet | Abrar F Alhameed Sara Al Khansa Hani Hasan Sherine Ismail Mohammed Aseeri |
| author_sort | Abrar F Alhameed |
| collection | DOAJ |
| description | Many hospitals face barriers in the implementation of TDM services, this study aimed to evaluate a pharmacist-led TDM service to optimize patients’ outcomes. Adult patients who were administered vancomycin, gentamicin, or amikacin were included. The pre-phase included a retrospective assessment of patients and the intervention phase consisted of an educational program. The post-phase assessed patients based on TDM services provided by inpatient pharmacists on a 24-h, 7-day basis for 3 months. The primary outcome was to assess the mean difference in proportion of correct initial doses of prescribing orders. Secondary outcomes included assessing the mean differences in proportions of correct dose adjustments and correct drug sampling time. Seventy-five patients in each phase were eligible. Patients who received optimal initial dosing in the post-phase showed a higher statistical significance, mean difference of 0.31, [95% CI (0.181⁻0.4438), <i>p</i> < 0.0001]. Patients in the post-phase received more optimal dose adjustments, mean difference of 0.1, [95% CI (−0.560⁻0.260), <i>p</i> = 0.2113]. Drug levels were ordered more correctly in the post-phase, mean difference of 0.03, [95% CI (−0.129⁻0.189), <i>p</i> = 0.7110]. This study demonstrated the important role of TDM services led by pharmacists in optimizing the initial dosing for these antibiotics. |
| first_indexed | 2024-04-11T14:04:09Z |
| format | Article |
| id | doaj.art-cad30c2543e446e69a983b6fa7d00e83 |
| institution | Directory Open Access Journal |
| issn | 2226-4787 |
| language | English |
| last_indexed | 2024-04-11T14:04:09Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmacy |
| spelling | doaj.art-cad30c2543e446e69a983b6fa7d00e832022-12-22T04:19:58ZengMDPI AGPharmacy2226-47872019-02-01712010.3390/pharmacy7010020pharmacy7010020Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug MonitoringAbrar F Alhameed0Sara Al Khansa1Hani Hasan2Sherine Ismail3Mohammed Aseeri4King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, 21423 Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, 21423 Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, 21423 Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, 21423 Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, 21423 Jeddah, Saudi ArabiaMany hospitals face barriers in the implementation of TDM services, this study aimed to evaluate a pharmacist-led TDM service to optimize patients’ outcomes. Adult patients who were administered vancomycin, gentamicin, or amikacin were included. The pre-phase included a retrospective assessment of patients and the intervention phase consisted of an educational program. The post-phase assessed patients based on TDM services provided by inpatient pharmacists on a 24-h, 7-day basis for 3 months. The primary outcome was to assess the mean difference in proportion of correct initial doses of prescribing orders. Secondary outcomes included assessing the mean differences in proportions of correct dose adjustments and correct drug sampling time. Seventy-five patients in each phase were eligible. Patients who received optimal initial dosing in the post-phase showed a higher statistical significance, mean difference of 0.31, [95% CI (0.181⁻0.4438), <i>p</i> < 0.0001]. Patients in the post-phase received more optimal dose adjustments, mean difference of 0.1, [95% CI (−0.560⁻0.260), <i>p</i> = 0.2113]. Drug levels were ordered more correctly in the post-phase, mean difference of 0.03, [95% CI (−0.129⁻0.189), <i>p</i> = 0.7110]. This study demonstrated the important role of TDM services led by pharmacists in optimizing the initial dosing for these antibiotics.https://www.mdpi.com/2226-4787/7/1/20drug monitoringvancomycinaminoglycosidesTDMinpatientpharmacist |
| spellingShingle | Abrar F Alhameed Sara Al Khansa Hani Hasan Sherine Ismail Mohammed Aseeri Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring Pharmacy drug monitoring vancomycin aminoglycosides TDM inpatient pharmacist |
| title | Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring |
| title_full | Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring |
| title_fullStr | Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring |
| title_full_unstemmed | Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring |
| title_short | Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring |
| title_sort | bridging the gap between theory and practice the active role of inpatient pharmacists in therapeutic drug monitoring |
| topic | drug monitoring vancomycin aminoglycosides TDM inpatient pharmacist |
| url | https://www.mdpi.com/2226-4787/7/1/20 |
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