First report of whole-genome analysis of an extensively drug-resistant Mycobacterium tuberculosis clinical isolate with bedaquiline, linezolid and clofazimine resistance from Uganda

First report of whole-genome analysis of an extensively drug-resistant Mycobacterium tuberculosis clinical isolate with bedaquiline, linezolid and clofazimine resistance from Uganda

Abstract Background Uganda remains one of the countries with the highest burden of TB/HIV. Drug-resistant TB remains a substantial challenge to TB control globally and requires new strategic effective control approaches. Drug resistance usually develops due to inadequate management of TB patients in...

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Bibliographic Details
Main Authors: Jupiter Marina Kabahita, Joel Kabugo, Francis Kakooza, Isa Adam, Ocung Guido, Henry Byabajungu, Joanitah Namutebi, Maria Magdalene Namaganda, Pius Lutaaya, James Otim, Fredrick Elishama Kakembo, Stephen Kanyerezi, Patricia Nabisubi, Ivan Sserwadda, George William Kasule, Hasfah Nakato, Kenneth Musisi, Denis Oola, Moses L. Joloba, Gerald Mboowa
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Antimicrobial Resistance and Infection Control
Subjects:
Bedaquiline
Linezolid
Clofazimine
Extensively drug-resistant TB (XDR-TB)
Whole-genome sequencing (WGS)
Mycobacterium tuberculosis
Online Access:https://doi.org/10.1186/s13756-022-01101-2

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