Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women
Purpose: This study aims to investigate the associations of the systemi c immune-inflammation index (SII) with bone mineral density (BMD) and ost eoporosis in adult females from a nationally representative sample. Methods: A cross-sectional study was performed among 4092 females aged ≥20 years fro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2023-01-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/12/2/EC-22-0461.xml |
| _version_ | 1797939193363562496 |
|---|---|
| author | Jiaxin Zhang Jinlan Jiang Yao Qin Yihui Zhang Yungang Wu Huadong Xu |
| author_facet | Jiaxin Zhang Jinlan Jiang Yao Qin Yihui Zhang Yungang Wu Huadong Xu |
| author_sort | Jiaxin Zhang |
| collection | DOAJ |
| description | Purpose: This study aims to investigate the associations of the systemi c immune-inflammation index (SII) with bone mineral density (BMD) and ost eoporosis in adult females from a nationally representative sample.
Methods: A cross-sectional study was performed among 4092 females aged ≥20 years from the National Health and Nutrition Examination Survey 2007– 2010. Linear and logistic regressions were applied to explore the relationships of SII with BMD and the risk of osteoporosis, respectively.
Results: Linear regression analyses found that a doubling of SII levels was significantly correlated with a 1.39% (95% CI: 0.57%, 2.20%) decrease in tota l femur BMD, a 1.16% (95% CI: 0.31%, 2.00%) decrease in femur neck BMD, a 1.73 % (95% CI: 0.78%, 2.66%) decrease in trochanter BMD, and a 1.35% (95% CI: 0.50%, 2.20%) decrease in intertrochanteric BMD among postmenopausal women, after adjusting for covariates. Logistic regression analyses showed that compared with postmeno pausal women in the lowest SII quartile, those in the highest quartile had higher r isks of osteoporosis in the total femur (odds ratio (OR) = 1.70, 95% CI: 1.04, 2.76), trochanter (OR = 1.86, 95% CI: 1.07, 3.38), intertrochanter (OR = 2.01, 95% CI: 1.05, 4.04) as well as overall osteoporosis (OR = 1.57, 95% CI: 1.04, 2.37). In contrast, there was no significan t association between SII and BMD in premenopausal women.
Conclusions: SII levels were negatively associated with BMD levels in postm enopausal women but not in premenopausal women. Elevated SII levels could be a potential risk factor for osteoporosis in postmenopausal women. |
| first_indexed | 2024-04-10T19:12:37Z |
| format | Article |
| id | doaj.art-cad88a92593e469d8afd3e411992c6ee |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-10T19:12:37Z |
| publishDate | 2023-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-cad88a92593e469d8afd3e411992c6ee2023-01-30T12:49:46ZengBioscientificaEndocrine Connections2049-36142023-01-01122110https://doi.org/10.1530/EC-22-0461Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal womenJiaxin Zhang0Jinlan Jiang1Yao Qin2Yihui Zhang3Yungang Wu4Huadong Xu5Department of Traditional Chinese Medicine (TCM) Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, ChinaSchool of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of Traditional Chinese Medicine (TCM) Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Traditional Chinese Medicine (TCM) Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaPurpose: This study aims to investigate the associations of the systemi c immune-inflammation index (SII) with bone mineral density (BMD) and ost eoporosis in adult females from a nationally representative sample. Methods: A cross-sectional study was performed among 4092 females aged ≥20 years from the National Health and Nutrition Examination Survey 2007– 2010. Linear and logistic regressions were applied to explore the relationships of SII with BMD and the risk of osteoporosis, respectively. Results: Linear regression analyses found that a doubling of SII levels was significantly correlated with a 1.39% (95% CI: 0.57%, 2.20%) decrease in tota l femur BMD, a 1.16% (95% CI: 0.31%, 2.00%) decrease in femur neck BMD, a 1.73 % (95% CI: 0.78%, 2.66%) decrease in trochanter BMD, and a 1.35% (95% CI: 0.50%, 2.20%) decrease in intertrochanteric BMD among postmenopausal women, after adjusting for covariates. Logistic regression analyses showed that compared with postmeno pausal women in the lowest SII quartile, those in the highest quartile had higher r isks of osteoporosis in the total femur (odds ratio (OR) = 1.70, 95% CI: 1.04, 2.76), trochanter (OR = 1.86, 95% CI: 1.07, 3.38), intertrochanter (OR = 2.01, 95% CI: 1.05, 4.04) as well as overall osteoporosis (OR = 1.57, 95% CI: 1.04, 2.37). In contrast, there was no significan t association between SII and BMD in premenopausal women. Conclusions: SII levels were negatively associated with BMD levels in postm enopausal women but not in premenopausal women. Elevated SII levels could be a potential risk factor for osteoporosis in postmenopausal women.https://ec.bioscientifica.com/view/journals/ec/12/2/EC-22-0461.xmlbone mass densityosteoporosissystemic immune-inflammation indexmenopausenhanes |
| spellingShingle | Jiaxin Zhang Jinlan Jiang Yao Qin Yihui Zhang Yungang Wu Huadong Xu Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women Endocrine Connections bone mass density osteoporosis systemic immune-inflammation index menopause nhanes |
| title | Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women |
| title_full | Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women |
| title_fullStr | Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women |
| title_full_unstemmed | Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women |
| title_short | Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women |
| title_sort | systemic immune inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women |
| topic | bone mass density osteoporosis systemic immune-inflammation index menopause nhanes |
| url | https://ec.bioscientifica.com/view/journals/ec/12/2/EC-22-0461.xml |
| work_keys_str_mv | AT jiaxinzhang systemicimmuneinflammationindexisassociatedwithdecreasedbonemassdensityandosteoporosisinpostmenopausalwomenbutnotinpremenopausalwomen AT jinlanjiang systemicimmuneinflammationindexisassociatedwithdecreasedbonemassdensityandosteoporosisinpostmenopausalwomenbutnotinpremenopausalwomen AT yaoqin systemicimmuneinflammationindexisassociatedwithdecreasedbonemassdensityandosteoporosisinpostmenopausalwomenbutnotinpremenopausalwomen AT yihuizhang systemicimmuneinflammationindexisassociatedwithdecreasedbonemassdensityandosteoporosisinpostmenopausalwomenbutnotinpremenopausalwomen AT yungangwu systemicimmuneinflammationindexisassociatedwithdecreasedbonemassdensityandosteoporosisinpostmenopausalwomenbutnotinpremenopausalwomen AT huadongxu systemicimmuneinflammationindexisassociatedwithdecreasedbonemassdensityandosteoporosisinpostmenopausalwomenbutnotinpremenopausalwomen |