Estimated Glycated albumin' levels early in pregnancy could detect women at risk to develop gestational diabetes mellitus
Background: Gestational diabetes mellitus (GDM) is characterized by dysfunction in maintaining glucose homeostasis leading to adverse maternofetal outcomes and this necessitates the use of markers for its early prediction. Objectives: To determine the ability of the estimated percentage of glycosyl...
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| Format: | Article |
| Language: | English |
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South Valley University, Faculty of Medicine
2023-07-01
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| Series: | SVU - International Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://svuijm.journals.ekb.eg/article_320253.html |
| _version_ | 1827761659847901184 |
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| author | Amr Sharafeldeen * Adel F. Al-Kholy Nareman Elhamamy |
| author_facet | Amr Sharafeldeen * Adel F. Al-Kholy Nareman Elhamamy |
| author_sort | Amr Sharafeldeen * |
| collection | DOAJ |
| description | Background: Gestational diabetes mellitus (GDM) is characterized by dysfunction in maintaining glucose homeostasis leading to adverse maternofetal outcomes and this necessitates the use of markers for its early prediction.
Objectives: To determine the ability of the estimated percentage of glycosylated hemoglobin (HbA1c%) and glycated albumin (GA%) at the 6th gestational week (GW) to define women liable to develop GDM.
Patients and methods: 402 women were clinically evaluated and gave blood samples for estimation of fasting blood glucose (FBG) and HbA1c% and GA% at the 6th-8th GW. At the 24th GW, all women underwent the evaluation of insulin resistance (IR) using the Homeostasis model assessment of IR score and the 75-Oral Glucose Tolerance Test (75-OGTT) to diagnose GDM. The levels of estimated variate at the 6th-8th GW were statistically analyzed to define the predictor for GDM.
Results: 62 women developed IR and 36 of them progressed to GDM. Statistical analyses defined FBG, GA%, HbA1c% as predictors for IR and GDM, but the Paired-sample area difference under the ROC curves defined high GA% as the significant positive predictor for GDM. Kaplan-Meier analysis defined GA% at 14% and 15% could define the risk for GDM by 20% and 40%, respectively but the evaluated performance characters at 15% were significantly (P=0.0074) higher than at 14 %.
Conclusion: Estimation of GA% in blood samples obtained at the 6th-8th GW could predict the oncoming GDM with high specificity and negative predictive value at the cutoff of 15%. |
| first_indexed | 2024-03-11T10:16:07Z |
| format | Article |
| id | doaj.art-cad8e8f7126e44d9ae29bd3235081f30 |
| institution | Directory Open Access Journal |
| issn | 2735-427X 2636-3402 |
| language | English |
| last_indexed | 2024-03-11T10:16:07Z |
| publishDate | 2023-07-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj.art-cad8e8f7126e44d9ae29bd3235081f302023-11-16T10:00:40ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022023-07-0162 787798https://doi.org/10.21608/svuijm.2023.187230.1492Estimated Glycated albumin' levels early in pregnancy could detect women at risk to develop gestational diabetes mellitusAmr Sharafeldeen *0 Adel F. Al-Kholy1Nareman Elhamamy2Department of Obstetrics & Gynecology, Faculty of Medicine, Benha University, Benha, EgyptDepartment of Medical Biochemistry, Faculty of Medicine, Benha University, Benha, Egypt.Department of Obstetrics & Gynecology, Faculty of Medicine, Tanta University, Tanta, Egypt.Background: Gestational diabetes mellitus (GDM) is characterized by dysfunction in maintaining glucose homeostasis leading to adverse maternofetal outcomes and this necessitates the use of markers for its early prediction. Objectives: To determine the ability of the estimated percentage of glycosylated hemoglobin (HbA1c%) and glycated albumin (GA%) at the 6th gestational week (GW) to define women liable to develop GDM. Patients and methods: 402 women were clinically evaluated and gave blood samples for estimation of fasting blood glucose (FBG) and HbA1c% and GA% at the 6th-8th GW. At the 24th GW, all women underwent the evaluation of insulin resistance (IR) using the Homeostasis model assessment of IR score and the 75-Oral Glucose Tolerance Test (75-OGTT) to diagnose GDM. The levels of estimated variate at the 6th-8th GW were statistically analyzed to define the predictor for GDM. Results: 62 women developed IR and 36 of them progressed to GDM. Statistical analyses defined FBG, GA%, HbA1c% as predictors for IR and GDM, but the Paired-sample area difference under the ROC curves defined high GA% as the significant positive predictor for GDM. Kaplan-Meier analysis defined GA% at 14% and 15% could define the risk for GDM by 20% and 40%, respectively but the evaluated performance characters at 15% were significantly (P=0.0074) higher than at 14 %. Conclusion: Estimation of GA% in blood samples obtained at the 6th-8th GW could predict the oncoming GDM with high specificity and negative predictive value at the cutoff of 15%.https://svuijm.journals.ekb.eg/article_320253.htmlgestational diabetes mellitus insulin resistance glycated albumin glycated hemoglobin early prediction |
| spellingShingle | Amr Sharafeldeen * Adel F. Al-Kholy Nareman Elhamamy Estimated Glycated albumin' levels early in pregnancy could detect women at risk to develop gestational diabetes mellitus SVU - International Journal of Medical Sciences gestational diabetes mellitus insulin resistance glycated albumin glycated hemoglobin early prediction |
| title | Estimated Glycated albumin' levels early in pregnancy could detect women at risk to develop gestational diabetes mellitus |
| title_full | Estimated Glycated albumin' levels early in pregnancy could detect women at risk to develop gestational diabetes mellitus |
| title_fullStr | Estimated Glycated albumin' levels early in pregnancy could detect women at risk to develop gestational diabetes mellitus |
| title_full_unstemmed | Estimated Glycated albumin' levels early in pregnancy could detect women at risk to develop gestational diabetes mellitus |
| title_short | Estimated Glycated albumin' levels early in pregnancy could detect women at risk to develop gestational diabetes mellitus |
| title_sort | estimated glycated albumin levels early in pregnancy could detect women at risk to develop gestational diabetes mellitus |
| topic | gestational diabetes mellitus insulin resistance glycated albumin glycated hemoglobin early prediction |
| url | https://svuijm.journals.ekb.eg/article_320253.html |
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