Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria
Over the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique, renewable and yet under-investigated pools for d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/6/214 |
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| author | Amr El-Demerdash Mohamed A. Tammam Atanas G. Atanasov John N. A. Hooper Ali Al-Mourabit Anake Kijjoa |
| author_facet | Amr El-Demerdash Mohamed A. Tammam Atanas G. Atanasov John N. A. Hooper Ali Al-Mourabit Anake Kijjoa |
| author_sort | Amr El-Demerdash |
| collection | DOAJ |
| description | Over the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique, renewable and yet under-investigated pools for discovery of new drug leads with distinct structural features, and myriad interesting biological activities. Marine sponges are the most primitive and simplest multicellular animals, with approximately 8900 known described species, although more than 15,000 species are thought to exist worldwide today. These marine organisms potentially represent the richest pipeline for novel drug leads. Mycale (Arenochalina) and Clathria are recognized marine sponge genera belonging to the order Poecilosclerida, whereas Biemna was more recently reclassified, based on molecular genetics, as a new order Biemnida. Together, these sponge genera contribute to the production of physiologically active molecular entities with diverse structural features and a wide range of medicinal and therapeutic potentialities. In this review, we provide a comprehensive insight and up-to-date literature survey over the period of 1976–2018, focusing on the chemistry of the isolated compounds from members of these three genera, as well as their biological and pharmacological activities, whenever available. |
| first_indexed | 2024-04-11T12:45:33Z |
| format | Article |
| id | doaj.art-cad98de672744c59a4f6554189a6b797 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:45:33Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-cad98de672744c59a4f6554189a6b7972022-12-22T04:23:21ZengMDPI AGMarine Drugs1660-33972018-06-0116621410.3390/md16060214md16060214Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and ClathriaAmr El-Demerdash0Mohamed A. Tammam1Atanas G. Atanasov2John N. A. Hooper3Ali Al-Mourabit4Anake Kijjoa5Muséum National d’Histoire Naturelle, Molécules de Communication et Adaptation des Micro-organismes, Sorbonne Universités, UMR 7245 CNRS/MNHN, CP 54, 57 Rue Cuvier, 75005 Paris, FranceDepartment of Pharmacognosy and Chemistry of Natural products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, GreeceDepartment of Pharmacognosy, University of Vienna, 1090 Vienna, AustriaQueensland Museum, Biodiversity & Geosciences Program, P.O. Box 3300, South Brisbane BC, Queensland 4101, AustraliaICSN—Institut de Chimie des Substances Naturelles, CNRS UPR 2301, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, FranceICBAS—Instituto de Ciências Biomédicas Abel Salazar & CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, PortugalOver the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique, renewable and yet under-investigated pools for discovery of new drug leads with distinct structural features, and myriad interesting biological activities. Marine sponges are the most primitive and simplest multicellular animals, with approximately 8900 known described species, although more than 15,000 species are thought to exist worldwide today. These marine organisms potentially represent the richest pipeline for novel drug leads. Mycale (Arenochalina) and Clathria are recognized marine sponge genera belonging to the order Poecilosclerida, whereas Biemna was more recently reclassified, based on molecular genetics, as a new order Biemnida. Together, these sponge genera contribute to the production of physiologically active molecular entities with diverse structural features and a wide range of medicinal and therapeutic potentialities. In this review, we provide a comprehensive insight and up-to-date literature survey over the period of 1976–2018, focusing on the chemistry of the isolated compounds from members of these three genera, as well as their biological and pharmacological activities, whenever available.http://www.mdpi.com/1660-3397/16/6/214marine spongesPoeciloscleridaBiemnidaMycale (Arenochalina), BiemnaClathriacrambescidinsbatzelladinesguanidine alkaloidspteridine alkaloidsterpenoidsthiopepetidesmacrolidespolyketidesindole alkaloidspyrrole-containing alkaloidsnucleotidesterpenoidssteroidsfatty acids |
| spellingShingle | Amr El-Demerdash Mohamed A. Tammam Atanas G. Atanasov John N. A. Hooper Ali Al-Mourabit Anake Kijjoa Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria Marine Drugs marine sponges Poecilosclerida Biemnida Mycale (Arenochalina), Biemna Clathria crambescidins batzelladines guanidine alkaloids pteridine alkaloids terpenoids thiopepetides macrolides polyketides indole alkaloids pyrrole-containing alkaloids nucleotides terpenoids steroids fatty acids |
| title | Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria |
| title_full | Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria |
| title_fullStr | Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria |
| title_full_unstemmed | Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria |
| title_short | Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria |
| title_sort | chemistry and biological activities of the marine sponges of the genera mycale arenochalina biemna and clathria |
| topic | marine sponges Poecilosclerida Biemnida Mycale (Arenochalina), Biemna Clathria crambescidins batzelladines guanidine alkaloids pteridine alkaloids terpenoids thiopepetides macrolides polyketides indole alkaloids pyrrole-containing alkaloids nucleotides terpenoids steroids fatty acids |
| url | http://www.mdpi.com/1660-3397/16/6/214 |
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