Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats

Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats

Brain ischemic preconditioning (PC) provides vital insights into the endogenous protection against stroke. Genomic and epigenetic responses to PC condition the brain into a state of ischemic tolerance. Notably, PC induces the elevation of histone acetylation, consistent with evidence that histone de...

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Bibliographic Details
Main Authors: Xiaoyu Yang, Qimei Wu, Lei Zhang, Linyin Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Calpain
preconditioning
MCAO
HDAC3
RGFP966
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00131/full

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