Preoperative systemic immune-inflammation index-based nomogram for lung carcinoma following microwave ablation -a real world single center study
BackgroundThe preoperative inflammatory condition significantly influences the prognosis of malignancies. We aimed to investigate the potential significance of preoperative inflammatory biomarkers in forecasting the long-term results of lung carcinoma after microwave ablation (MWA).MethodThis study...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1305262/full |
| _version_ | 1797256584242397184 |
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| author | Jing Wang Song-ping Cui Qing Zhao Ya Gao Ying Ji Yi Liu Jin-bai Miao Yi-li Fu Bin Hu |
| author_facet | Jing Wang Song-ping Cui Qing Zhao Ya Gao Ying Ji Yi Liu Jin-bai Miao Yi-li Fu Bin Hu |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | BackgroundThe preoperative inflammatory condition significantly influences the prognosis of malignancies. We aimed to investigate the potential significance of preoperative inflammatory biomarkers in forecasting the long-term results of lung carcinoma after microwave ablation (MWA).MethodThis study included patients who received MWA treatment for lung carcinoma from Jan. 2012 to Dec. 2020. We collected demographic, clinical, laboratory, and outcome information. To assess the predictive capacity of inflammatory biomarkers, we utilized the area under the receiver operating characteristic curve (AUC-ROC) and assessed the predictive potential of inflammatory biomarkers in forecasting outcomes through both univariate and multivariate Cox proportional hazard analyses.ResultsA total of 354 individuals underwent MWA treatment, of which 265 cases were included in this study, whose average age was 69.1 ± 9.7 years. The AUC values for the Systemic Inflammatory Response Index (SIRI) to overall survival (OS) and disease-free survival (DFS) were 0.796 and 0.716, respectively. The Cox proportional hazards model demonstrated a significant independent association between a high SIRI and a decreased overall survival (hazard ratio [HR]=2.583, P<0.001). Furthermore, a high SIRI independently correlated with a lower DFS (HR=2.391, P<0.001). We developed nomograms utilizing various independent factors to forecast the extended prognosis of patients. These nomograms exhibited AUC of 0.900, 0.849, and 0.862 for predicting 1-year, 3-year, and 5-year OS, respectively. Additionally, the AUC values for predicting 1-year, 3-year, and 5-year DFS were 0.851, 0.873, and 0.883, respectively.ConclusionSIRI has shown promise as a valuable long-term prognostic indicator for forecasting the outcomes of lung carcinoma patients following MWA. |
| first_indexed | 2024-04-24T22:24:04Z |
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| id | doaj.art-cadc54ad38b745d09ee82e8d33f41b42 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T22:24:04Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj.art-cadc54ad38b745d09ee82e8d33f41b422024-03-20T04:34:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-03-011410.3389/fonc.2024.13052621305262Preoperative systemic immune-inflammation index-based nomogram for lung carcinoma following microwave ablation -a real world single center studyJing WangSong-ping CuiQing ZhaoYa GaoYing JiYi LiuJin-bai MiaoYi-li FuBin HuBackgroundThe preoperative inflammatory condition significantly influences the prognosis of malignancies. We aimed to investigate the potential significance of preoperative inflammatory biomarkers in forecasting the long-term results of lung carcinoma after microwave ablation (MWA).MethodThis study included patients who received MWA treatment for lung carcinoma from Jan. 2012 to Dec. 2020. We collected demographic, clinical, laboratory, and outcome information. To assess the predictive capacity of inflammatory biomarkers, we utilized the area under the receiver operating characteristic curve (AUC-ROC) and assessed the predictive potential of inflammatory biomarkers in forecasting outcomes through both univariate and multivariate Cox proportional hazard analyses.ResultsA total of 354 individuals underwent MWA treatment, of which 265 cases were included in this study, whose average age was 69.1 ± 9.7 years. The AUC values for the Systemic Inflammatory Response Index (SIRI) to overall survival (OS) and disease-free survival (DFS) were 0.796 and 0.716, respectively. The Cox proportional hazards model demonstrated a significant independent association between a high SIRI and a decreased overall survival (hazard ratio [HR]=2.583, P<0.001). Furthermore, a high SIRI independently correlated with a lower DFS (HR=2.391, P<0.001). We developed nomograms utilizing various independent factors to forecast the extended prognosis of patients. These nomograms exhibited AUC of 0.900, 0.849, and 0.862 for predicting 1-year, 3-year, and 5-year OS, respectively. Additionally, the AUC values for predicting 1-year, 3-year, and 5-year DFS were 0.851, 0.873, and 0.883, respectively.ConclusionSIRI has shown promise as a valuable long-term prognostic indicator for forecasting the outcomes of lung carcinoma patients following MWA.https://www.frontiersin.org/articles/10.3389/fonc.2024.1305262/fulllung carcinomamicrowave ablationbiomarkerssystemic inflammatory response indexprognosis |
| spellingShingle | Jing Wang Song-ping Cui Qing Zhao Ya Gao Ying Ji Yi Liu Jin-bai Miao Yi-li Fu Bin Hu Preoperative systemic immune-inflammation index-based nomogram for lung carcinoma following microwave ablation -a real world single center study Frontiers in Oncology lung carcinoma microwave ablation biomarkers systemic inflammatory response index prognosis |
| title | Preoperative systemic immune-inflammation index-based nomogram for lung carcinoma following microwave ablation -a real world single center study |
| title_full | Preoperative systemic immune-inflammation index-based nomogram for lung carcinoma following microwave ablation -a real world single center study |
| title_fullStr | Preoperative systemic immune-inflammation index-based nomogram for lung carcinoma following microwave ablation -a real world single center study |
| title_full_unstemmed | Preoperative systemic immune-inflammation index-based nomogram for lung carcinoma following microwave ablation -a real world single center study |
| title_short | Preoperative systemic immune-inflammation index-based nomogram for lung carcinoma following microwave ablation -a real world single center study |
| title_sort | preoperative systemic immune inflammation index based nomogram for lung carcinoma following microwave ablation a real world single center study |
| topic | lung carcinoma microwave ablation biomarkers systemic inflammatory response index prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1305262/full |
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