P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients
Background: Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance. Purpose: To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients. Methods: 88 patients (66...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-02-01
|
| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125934620/view |
| _version_ | 1818006292369768448 |
|---|---|
| author | Angela Cozma Adriana Fodor Vasile Negrean Dorel Sampelean Ionut Minciuna Monica Oltean Ionela Popovici Sorina Coste Alexandra Dadarlat Dana Pop Olga Hilda Orasan Adela-Viviana Sitar-Taut |
| author_facet | Angela Cozma Adriana Fodor Vasile Negrean Dorel Sampelean Ionut Minciuna Monica Oltean Ionela Popovici Sorina Coste Alexandra Dadarlat Dana Pop Olga Hilda Orasan Adela-Viviana Sitar-Taut |
| author_sort | Angela Cozma |
| collection | DOAJ |
| description | Background: Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance.
Purpose: To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients.
Methods: 88 patients (66 women), mean age 61.96 ± 10.15. Cardiovascular risk factors (body weight, waist circumference, lipid fractions, smoking, diabetes, hypertension) and chemerin were assessed. Insulin resistance scores were calculated: Homeostatic model assessment (HOMA) = insulin (μU/mL) * glicemia (mg/dl)/405 and Quantitative insulin sensitivity check index (QUICKI = 1/[lg10 (insulin (μU/mL)) + lg10 (glicemia)]. Patients were categorized in obese only (20.5%), diabetics only (12.5%), obese and diabetics (14.8%) and non-diabetics-non obese (52.3%).
Results: 35.3% patients were obese, 27.3% diabetics, 79.5% hypertensive, 17% current smokers, 67% dyslipidaemic. The values of chemerin registered in the four groups were as follows: in diabetic + obese patients 7.98 ± 7.22 pg/ml (median 5.2), diabetics only 7.27 ± 5.24 pg/ml (5.6), obese only 8.42 ± 7.56 pg/ml (median 5.8), non-obese-non-diabetics 9.15 ± 7.64 pg/ml (median 7.15). Globally chemerin did not correlate with waist circumference, HDL-cholesterol, LDL-cholesterol, glicemia, insulin, HOMA index or QUICKI index. Going further with analysis, no significant correlations were found between chemerin and HOMA index and QUICKI index in diabetic + obese patients, obese only patients, diabetics only. But, in non-obese-non-diabetics significant correlations were found – between chemerin and glicemia (r = 0.3), HOMA index (r = 0.3, p = 0.03), QUICKI index (r = −0.310, p = 0.037), but not with waist circumference (r = 0.224, p = NS), HDL (r = 0.08, p = NS) or LDL (r = −0.06, p = NS).
Conclusion: Although many things need to be elucidated regarding the chemerin mechanism, it seems very probable to be involved in early insulin resistance. |
| first_indexed | 2024-04-14T04:59:13Z |
| format | Article |
| id | doaj.art-cadd2232bc7e420a9ec6ac90a200491e |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-14T04:59:13Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-cadd2232bc7e420a9ec6ac90a200491e2022-12-22T02:11:03ZengBMCArtery Research1876-44012020-02-0125110.2991/artres.k.191224.169P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese PatientsAngela CozmaAdriana FodorVasile NegreanDorel SampeleanIonut MinciunaMonica OlteanIonela PopoviciSorina CosteAlexandra DadarlatDana PopOlga Hilda OrasanAdela-Viviana Sitar-TautBackground: Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance. Purpose: To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients. Methods: 88 patients (66 women), mean age 61.96 ± 10.15. Cardiovascular risk factors (body weight, waist circumference, lipid fractions, smoking, diabetes, hypertension) and chemerin were assessed. Insulin resistance scores were calculated: Homeostatic model assessment (HOMA) = insulin (μU/mL) * glicemia (mg/dl)/405 and Quantitative insulin sensitivity check index (QUICKI = 1/[lg10 (insulin (μU/mL)) + lg10 (glicemia)]. Patients were categorized in obese only (20.5%), diabetics only (12.5%), obese and diabetics (14.8%) and non-diabetics-non obese (52.3%). Results: 35.3% patients were obese, 27.3% diabetics, 79.5% hypertensive, 17% current smokers, 67% dyslipidaemic. The values of chemerin registered in the four groups were as follows: in diabetic + obese patients 7.98 ± 7.22 pg/ml (median 5.2), diabetics only 7.27 ± 5.24 pg/ml (5.6), obese only 8.42 ± 7.56 pg/ml (median 5.8), non-obese-non-diabetics 9.15 ± 7.64 pg/ml (median 7.15). Globally chemerin did not correlate with waist circumference, HDL-cholesterol, LDL-cholesterol, glicemia, insulin, HOMA index or QUICKI index. Going further with analysis, no significant correlations were found between chemerin and HOMA index and QUICKI index in diabetic + obese patients, obese only patients, diabetics only. But, in non-obese-non-diabetics significant correlations were found – between chemerin and glicemia (r = 0.3), HOMA index (r = 0.3, p = 0.03), QUICKI index (r = −0.310, p = 0.037), but not with waist circumference (r = 0.224, p = NS), HDL (r = 0.08, p = NS) or LDL (r = −0.06, p = NS). Conclusion: Although many things need to be elucidated regarding the chemerin mechanism, it seems very probable to be involved in early insulin resistance.https://www.atlantis-press.com/article/125934620/view |
| spellingShingle | Angela Cozma Adriana Fodor Vasile Negrean Dorel Sampelean Ionut Minciuna Monica Oltean Ionela Popovici Sorina Coste Alexandra Dadarlat Dana Pop Olga Hilda Orasan Adela-Viviana Sitar-Taut P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients Artery Research |
| title | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_full | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_fullStr | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_full_unstemmed | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_short | P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients |
| title_sort | p149 the relationship between insulin resistance scores parameters and chemerin in diabetic and obese patients |
| url | https://www.atlantis-press.com/article/125934620/view |
| work_keys_str_mv | AT angelacozma p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT adrianafodor p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT vasilenegrean p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT dorelsampelean p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT ionutminciuna p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT monicaoltean p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT ionelapopovici p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT sorinacoste p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT alexandradadarlat p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT danapop p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT olgahildaorasan p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients AT adelavivianasitartaut p149therelationshipbetweeninsulinresistancescoresparametersandchemerinindiabeticandobesepatients |