Ischemic preconditioning: Protection against myocardial necrosis and apoptosis
Efstathios K Iliodromitis1, Antigone Lazou2, Dimitrios Th Kremastinos112nd University Department of Cardiology, Medical School, University of Athens, Greece; 2Lab of Animal Physiology, School of Biology, Aristotle University of Thessaloniki, GreeceAbstract: The phenomenon of ischemic preconditioning...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2007-11-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | https://www.dovepress.com/ischemic-preconditioning-protection-against-myocardial-necrosis-and-ap-peer-reviewed-article-VHRM |
| _version_ | 1818443402760421376 |
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| author | Efstathios K Iliodromitis Antigone Lazou Dimitrios Th Kremastinos |
| author_facet | Efstathios K Iliodromitis Antigone Lazou Dimitrios Th Kremastinos |
| author_sort | Efstathios K Iliodromitis |
| collection | DOAJ |
| description | Efstathios K Iliodromitis1, Antigone Lazou2, Dimitrios Th Kremastinos112nd University Department of Cardiology, Medical School, University of Athens, Greece; 2Lab of Animal Physiology, School of Biology, Aristotle University of Thessaloniki, GreeceAbstract: The phenomenon of ischemic preconditioning has been recognized as one of the most potent mechanisms to protect against myocardial ischemic injury. In experimental animals and humans, a brief period of ischemia has been shown to protect the heart from more prolonged episodes of ischemia, reducing infarct size, attenuating the incidence, and severity of reperfusion-induced arrhythmias, and preventing endothelial cell dysfunction. Although the exact mechanism of ischemic preconditioning remains obscure, several reports indicate that this phenomenon may be a form of receptor-mediated cardiac protection and that the underlying intracellular signal transduction pathways involve activation of a number of protein kinases, including protein kinase C, and mitochondrial KATP channels. Apoptosis, a genetically programmed form of cell death, has been associated with cardiomyocyte cell loss in a variety of cardiac pathologies, including cardiac failure and those related to ischemia/reperfusion injury. While ischemic preconditioning significantly reduces DNA fragmentation and apoptotic myocyte death associated with ischemia-reperfusion, the potential mechanisms underlying this effect have not been fully clarified. A comprehensive understanding of these mechanisms and application to clinical scenarios will provide new directions in research and translate this information into new treatment approaches for reducing the extent of ischemia/reperfusion injury.Keywords: preconditioning, ischemia, reperfusion, necrosis, apoptosis |
| first_indexed | 2024-12-14T18:59:29Z |
| format | Article |
| id | doaj.art-cade12a996f24905bde5a063c3a5b10f |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-14T18:59:29Z |
| publishDate | 2007-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-cade12a996f24905bde5a063c3a5b10f2022-12-21T22:51:00ZengDove Medical PressVascular Health and Risk Management1178-20482007-11-01Volume 36296371529Ischemic preconditioning: Protection against myocardial necrosis and apoptosisEfstathios K IliodromitisAntigone LazouDimitrios Th KremastinosEfstathios K Iliodromitis1, Antigone Lazou2, Dimitrios Th Kremastinos112nd University Department of Cardiology, Medical School, University of Athens, Greece; 2Lab of Animal Physiology, School of Biology, Aristotle University of Thessaloniki, GreeceAbstract: The phenomenon of ischemic preconditioning has been recognized as one of the most potent mechanisms to protect against myocardial ischemic injury. In experimental animals and humans, a brief period of ischemia has been shown to protect the heart from more prolonged episodes of ischemia, reducing infarct size, attenuating the incidence, and severity of reperfusion-induced arrhythmias, and preventing endothelial cell dysfunction. Although the exact mechanism of ischemic preconditioning remains obscure, several reports indicate that this phenomenon may be a form of receptor-mediated cardiac protection and that the underlying intracellular signal transduction pathways involve activation of a number of protein kinases, including protein kinase C, and mitochondrial KATP channels. Apoptosis, a genetically programmed form of cell death, has been associated with cardiomyocyte cell loss in a variety of cardiac pathologies, including cardiac failure and those related to ischemia/reperfusion injury. While ischemic preconditioning significantly reduces DNA fragmentation and apoptotic myocyte death associated with ischemia-reperfusion, the potential mechanisms underlying this effect have not been fully clarified. A comprehensive understanding of these mechanisms and application to clinical scenarios will provide new directions in research and translate this information into new treatment approaches for reducing the extent of ischemia/reperfusion injury.Keywords: preconditioning, ischemia, reperfusion, necrosis, apoptosishttps://www.dovepress.com/ischemic-preconditioning-protection-against-myocardial-necrosis-and-ap-peer-reviewed-article-VHRM |
| spellingShingle | Efstathios K Iliodromitis Antigone Lazou Dimitrios Th Kremastinos Ischemic preconditioning: Protection against myocardial necrosis and apoptosis Vascular Health and Risk Management |
| title | Ischemic preconditioning: Protection against myocardial necrosis and apoptosis |
| title_full | Ischemic preconditioning: Protection against myocardial necrosis and apoptosis |
| title_fullStr | Ischemic preconditioning: Protection against myocardial necrosis and apoptosis |
| title_full_unstemmed | Ischemic preconditioning: Protection against myocardial necrosis and apoptosis |
| title_short | Ischemic preconditioning: Protection against myocardial necrosis and apoptosis |
| title_sort | ischemic preconditioning protection against myocardial necrosis and apoptosis |
| url | https://www.dovepress.com/ischemic-preconditioning-protection-against-myocardial-necrosis-and-ap-peer-reviewed-article-VHRM |
| work_keys_str_mv | AT efstathioskiliodromitis ischemicpreconditioningprotectionagainstmyocardialnecrosisandapoptosis AT antigonelazou ischemicpreconditioningprotectionagainstmyocardialnecrosisandapoptosis AT dimitriosthkremastinos ischemicpreconditioningprotectionagainstmyocardialnecrosisandapoptosis |