Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of action
Introduction: A promising compound for the treatment of inflammatory periodontal diseases is benzofuracaine (BFC). BFC has pronounced anti-inflammatory, analgesic, reparative, hypoglycemic and other effects. Objective: To assess the influence of benzofuracaine on experimental periodontitis and to st...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2019-03-01
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| Series: | Research Results in Pharmacology |
| Online Access: | https://rrpharmacology.pensoft.net/article/33100/download/pdf/ |
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| author | Pavel A. Galenko-Yaroshevsky Viktor L. Popkov Karine A. Bedrosova Leonid A. Faustov Galina V. Sukoyan Andrej V. Zadorozhny Ol’ga N. Gulevskaya Aleksandr V. Uvarov Valeriya S. Dobrodomova |
| author_facet | Pavel A. Galenko-Yaroshevsky Viktor L. Popkov Karine A. Bedrosova Leonid A. Faustov Galina V. Sukoyan Andrej V. Zadorozhny Ol’ga N. Gulevskaya Aleksandr V. Uvarov Valeriya S. Dobrodomova |
| author_sort | Pavel A. Galenko-Yaroshevsky |
| collection | DOAJ |
| description | Introduction: A promising compound for the treatment of inflammatory periodontal diseases is benzofuracaine (BFC). BFC has pronounced anti-inflammatory, analgesic, reparative, hypoglycemic and other effects. Objective: To assess the influence of benzofuracaine on experimental periodontitis and to study its antidiabetic activity and molecular mechanisms of action
Materials and methods: The work was performed on 232 white nonlinear rats of both sexes and 55 male mice. To assess the effect of BFС on experimental periodontitis, the amount of gingival fluid (AGF) was determined, an in-depth morphofunctional study of periodontal tissues was conducted, as well as the study of the biochemical composition of the gingiva and blood. Antidiabetic properties were studied using the glucose tolerance test (GTT), as well as the assessment of endothelium-dependent vasodilation and transmembrane K+-currents on an isolated aortic segment of rats with streptozotocin-induced diabetes mellitus (DM).
Results and discussion: In experimental periodontitis, BFC improves the morphological picture and decreases AGF, increases the level of blood microcirculation in the attached gingiva, has a normalizing effect on the prekallikrein-kallikrein system, reduces the synthesis of bradykinin, proinflammatory cytokines and PGE2, increases the level of VEGF, reduces the level of endothelin-1, increases the ATP content and NADH-ubiquinone-reductase activity, exhibits antioxidant properties, reduces the content of nitrosothiols and NO metabolites (NO2/NO3), increases the level of transferrin; when conducting a glucose tolerance test in mice, it reduces the level of glucose in the blood, but in this respect is inferior to glibenclamide, has a hypoglycemic effect in the early stages of diabetes (30 days), tends to restore endothelium-dependent dilatation of smooth muscle cells (SMC) of the aorta and does not affect the functioning of the K+-channels of the aortic SMC.
Conclusion: BFС is an effective drug for the treatment of periodontitis and can be recommended for further preclinical and clinical studies. |
| first_indexed | 2024-03-09T09:09:24Z |
| format | Article |
| id | doaj.art-cae2ad6b59964b12a6c462dfb56df9fb |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:09:24Z |
| publishDate | 2019-03-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-cae2ad6b59964b12a6c462dfb56df9fb2023-12-02T09:24:16ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2019-03-0151153010.3897/rrpharmacology.5.3310033100Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of actionPavel A. Galenko-Yaroshevsky0Viktor L. Popkov1Karine A. Bedrosova2Leonid A. Faustov3Galina V. Sukoyan4Andrej V. Zadorozhny5Ol’ga N. Gulevskaya6Aleksandr V. Uvarov7Valeriya S. Dobrodomova8Kuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityKuban Medical InstituteInternational Scientific Centre for Introduction and Development of New Biomedical TechnologiesRostov State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityIntroduction: A promising compound for the treatment of inflammatory periodontal diseases is benzofuracaine (BFC). BFC has pronounced anti-inflammatory, analgesic, reparative, hypoglycemic and other effects. Objective: To assess the influence of benzofuracaine on experimental periodontitis and to study its antidiabetic activity and molecular mechanisms of action Materials and methods: The work was performed on 232 white nonlinear rats of both sexes and 55 male mice. To assess the effect of BFС on experimental periodontitis, the amount of gingival fluid (AGF) was determined, an in-depth morphofunctional study of periodontal tissues was conducted, as well as the study of the biochemical composition of the gingiva and blood. Antidiabetic properties were studied using the glucose tolerance test (GTT), as well as the assessment of endothelium-dependent vasodilation and transmembrane K+-currents on an isolated aortic segment of rats with streptozotocin-induced diabetes mellitus (DM). Results and discussion: In experimental periodontitis, BFC improves the morphological picture and decreases AGF, increases the level of blood microcirculation in the attached gingiva, has a normalizing effect on the prekallikrein-kallikrein system, reduces the synthesis of bradykinin, proinflammatory cytokines and PGE2, increases the level of VEGF, reduces the level of endothelin-1, increases the ATP content and NADH-ubiquinone-reductase activity, exhibits antioxidant properties, reduces the content of nitrosothiols and NO metabolites (NO2/NO3), increases the level of transferrin; when conducting a glucose tolerance test in mice, it reduces the level of glucose in the blood, but in this respect is inferior to glibenclamide, has a hypoglycemic effect in the early stages of diabetes (30 days), tends to restore endothelium-dependent dilatation of smooth muscle cells (SMC) of the aorta and does not affect the functioning of the K+-channels of the aortic SMC. Conclusion: BFС is an effective drug for the treatment of periodontitis and can be recommended for further preclinical and clinical studies.https://rrpharmacology.pensoft.net/article/33100/download/pdf/ |
| spellingShingle | Pavel A. Galenko-Yaroshevsky Viktor L. Popkov Karine A. Bedrosova Leonid A. Faustov Galina V. Sukoyan Andrej V. Zadorozhny Ol’ga N. Gulevskaya Aleksandr V. Uvarov Valeriya S. Dobrodomova Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of action Research Results in Pharmacology |
| title | Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of action |
| title_full | Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of action |
| title_fullStr | Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of action |
| title_full_unstemmed | Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of action |
| title_short | Benzofurocaine: effects on experimental periodontitis, anti-diabetic activity and molecular mechanisms of action |
| title_sort | benzofurocaine effects on experimental periodontitis anti diabetic activity and molecular mechanisms of action |
| url | https://rrpharmacology.pensoft.net/article/33100/download/pdf/ |
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