Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19

Summary: In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular, and transcriptomic imprints of...

Full description

Bibliographic Details
Main Authors: Christoph Schultheiß, Lisa Paschold, Edith Willscher, Donjete Simnica, Anna Wöstemeier, Franziska Muscate, Maxi Wass, Stephan Eisenmann, Jochen Dutzmann, Gernot Keyßer, Nicola Gagliani, Mascha Binder
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Immunology
Virology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221012943

Similar Items

Similar Items