Interactive effects between CDHR3 genotype and rhinovirus species for diagnosis and severity of respiratory tract infections in hospitalized children

Interactive effects between CDHR3 genotype and rhinovirus species for diagnosis and severity of respiratory tract infections in hospitalized children

ABSTRACT Rhinovirus (RV) is the leading pathogen causing childhood wheezing, with rhinovirus C (RV-C) species reported to cause asthma exacerbation. Allele A of single-nucleotide polymorphism (SNP) CDHR3_rs6967330 upregulates epithelial expression of RV-C receptors which results in more severe asthm...

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Bibliographic Details
Main Authors: Yu P. Song, Man F. Tang, Agnes S. Y. Leung, Kin P. Tao, Oi M. Chan, Gary W. K. Wong, Paul K. S. Chan, Renee W. Y. Chan, Ting F. Leung
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
CDHR3
children
gene-environment interaction
respiratory tract infection
rhinovirus
wheezing
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01181-23

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