Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China
Abstract Background Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the fact...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Child and Adolescent Psychiatry and Mental Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13034-023-00601-2 |
| _version_ | 1797841174734569472 |
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| author | Yesheng Zhou Kailing Tang Hongyan Lu Hongli Chen Haomin Xie Zeyu Li Jinghua Huang Ningye Fang Siya Chen Hong Wang Qin He Huanhuan Chen Xiu Liu Guanghua Lan Qiuying Zhu Yi Chen Xiangjun Zhang Yuhua Ruan Shujia Liang |
| author_facet | Yesheng Zhou Kailing Tang Hongyan Lu Hongli Chen Haomin Xie Zeyu Li Jinghua Huang Ningye Fang Siya Chen Hong Wang Qin He Huanhuan Chen Xiu Liu Guanghua Lan Qiuying Zhu Yi Chen Xiangjun Zhang Yuhua Ruan Shujia Liang |
| author_sort | Yesheng Zhou |
| collection | DOAJ |
| description | Abstract Background Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes. Methods This cross-sectional study was conducted in Guangxi, China, between July and August 2021. HIV-infected children answered questionnaires about BEDs, physical health, social support, and whether they have missed doses in the past month. BEDs were assessed using the Chinese version of the self-reported Strengths and Difficulties Questionnaire (SDQ-C). The self-reported survey data were linked to participants’ HIV care information that was obtained from the national surveillance database. Univariate and multivariate logistic regression models were used to identify factors that were associated with missed doses in the past month and virological failure. Results The study sample was 325 HIV-infected children. HIV-infected children had a higher proportion of abnormal scores on SDQ-C total difficulties compared to their peers in the general population (16.9 vs 10.0%; P = 0.002). An abnormal SDQ-C total difficulties score (AOR = 2.06, 95%CI: 1.10–3.88) and infrequency of receiving assistance and support from parents over the past 3 months (AOR = 1.85, 95%CI: 1.12–3.06) were significantly associated with missed doses in the past month. Between the ages of 14–17 years (AOR = 2.66, 95% CI: 1.37–5.16), female (AOR = 2.21, 95% CI: 1.20–4.08), and suboptimal adherence (AOR = 2.45, 95% CI: 1.32–4.57) were significantly associated with virological failure. Conclusions Children’s mental health plays a role in HIV treatment outcomes. Psychological interventions should be promoted in pediatric HIV care clinics to improve children’s mental health status and HIV treatment outcomes. |
| first_indexed | 2024-04-09T16:26:49Z |
| format | Article |
| id | doaj.art-cae45cb8e01b45c18f3cb5f24097a7a0 |
| institution | Directory Open Access Journal |
| issn | 1753-2000 |
| language | English |
| last_indexed | 2024-04-09T16:26:49Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Child and Adolescent Psychiatry and Mental Health |
| spelling | doaj.art-cae45cb8e01b45c18f3cb5f24097a7a02023-04-23T11:09:44ZengBMCChild and Adolescent Psychiatry and Mental Health1753-20002023-04-0117111010.1186/s13034-023-00601-2Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern ChinaYesheng Zhou0Kailing Tang1Hongyan Lu2Hongli Chen3Haomin Xie4Zeyu Li5Jinghua Huang6Ningye Fang7Siya Chen8Hong Wang9Qin He10Huanhuan Chen11Xiu Liu12Guanghua Lan13Qiuying Zhu14Yi Chen15Xiangjun Zhang16Yuhua Ruan17Shujia Liang18State Key Laboratory of Infectious Disease Prevention and Control (SKLID), National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionState Key Laboratory of Infectious Disease Prevention and Control (SKLID), National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionState Key Laboratory of Infectious Disease Prevention and Control (SKLID), National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science CenterState Key Laboratory of Infectious Disease Prevention and Control (SKLID), National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesGuangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response, Guangxi Center for Disease Control and PreventionAbstract Background Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes. Methods This cross-sectional study was conducted in Guangxi, China, between July and August 2021. HIV-infected children answered questionnaires about BEDs, physical health, social support, and whether they have missed doses in the past month. BEDs were assessed using the Chinese version of the self-reported Strengths and Difficulties Questionnaire (SDQ-C). The self-reported survey data were linked to participants’ HIV care information that was obtained from the national surveillance database. Univariate and multivariate logistic regression models were used to identify factors that were associated with missed doses in the past month and virological failure. Results The study sample was 325 HIV-infected children. HIV-infected children had a higher proportion of abnormal scores on SDQ-C total difficulties compared to their peers in the general population (16.9 vs 10.0%; P = 0.002). An abnormal SDQ-C total difficulties score (AOR = 2.06, 95%CI: 1.10–3.88) and infrequency of receiving assistance and support from parents over the past 3 months (AOR = 1.85, 95%CI: 1.12–3.06) were significantly associated with missed doses in the past month. Between the ages of 14–17 years (AOR = 2.66, 95% CI: 1.37–5.16), female (AOR = 2.21, 95% CI: 1.20–4.08), and suboptimal adherence (AOR = 2.45, 95% CI: 1.32–4.57) were significantly associated with virological failure. Conclusions Children’s mental health plays a role in HIV treatment outcomes. Psychological interventions should be promoted in pediatric HIV care clinics to improve children’s mental health status and HIV treatment outcomes.https://doi.org/10.1186/s13034-023-00601-2Behavioral and emotional problemsStrengths and Difficulties QuestionnaireChildrenHIVAntiretroviral therapyTreatment outcome |
| spellingShingle | Yesheng Zhou Kailing Tang Hongyan Lu Hongli Chen Haomin Xie Zeyu Li Jinghua Huang Ningye Fang Siya Chen Hong Wang Qin He Huanhuan Chen Xiu Liu Guanghua Lan Qiuying Zhu Yi Chen Xiangjun Zhang Yuhua Ruan Shujia Liang Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China Child and Adolescent Psychiatry and Mental Health Behavioral and emotional problems Strengths and Difficulties Questionnaire Children HIV Antiretroviral therapy Treatment outcome |
| title | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
| title_full | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
| title_fullStr | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
| title_full_unstemmed | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
| title_short | Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China |
| title_sort | behavioral and emotional difficulties and hiv treatment outcomes among hiv infected children in rural southwestern china |
| topic | Behavioral and emotional problems Strengths and Difficulties Questionnaire Children HIV Antiretroviral therapy Treatment outcome |
| url | https://doi.org/10.1186/s13034-023-00601-2 |
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