Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model
Melatonin is a hormone secreted by the pineal gland, it can be associated with circadian rhythms, aging and neuroprotection. Melatonin levels are decreased in sporadic Alzheimer's disease (sAD) patients, which suggests a relationship between the melatonergic system and sAD. Melatonin may reduce...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
|
| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123000052 |
| _version_ | 1797804555826626560 |
|---|---|
| author | Marcos K. Andrade Leonardo C. Souza Evellyn M. Azevedo Ellen L. Bail Silvio M. Zanata Roberto Andreatini Maria A.B.F. Vital |
| author_facet | Marcos K. Andrade Leonardo C. Souza Evellyn M. Azevedo Ellen L. Bail Silvio M. Zanata Roberto Andreatini Maria A.B.F. Vital |
| author_sort | Marcos K. Andrade |
| collection | DOAJ |
| description | Melatonin is a hormone secreted by the pineal gland, it can be associated with circadian rhythms, aging and neuroprotection. Melatonin levels are decreased in sporadic Alzheimer's disease (sAD) patients, which suggests a relationship between the melatonergic system and sAD. Melatonin may reduce inflammation, oxidative stress, TAU protein hyperphosphorylation, and the formation of β-amyloid (Aβ) aggregates. Therefore, the objective of this work was to investigate the impact of treatment with 10 mg/kg of melatonin (i.p) in the animal model of sAD induced by the intracerebroventricular (ICV) infusion of 3 mg/kg of streptozotocin (STZ). ICV-STZ causes changes in the brain of rats similar to those found in patients with sAD. These changes include; progressive memory decline, the formation of neurofibrillary tangles, senile plaques, disturbances in glucose metabolism, insulin resistance and even reactive astrogliosis characterized by the upregulation of glucose levels and glial fibrillary acidic protein (GFAP). The results show that ICV-STZ caused short-term spatial memory impairment in rats after 30 days of STZ infusion without locomotor impairment which was evaluated on day 27 post-injury. Furthermore, we observed that a prolonged 30-day treatment with melatonin can improve the cognitive impairment of animals in the Y-maze test, but not in the object location test. Finally, we demonstrated that animals receiving ICV-STZ have high levels of Aβ and GFAP in the hippocampus and that treatment with melatonin reduces Aβ levels but does not reduce GFAP levels, concluding that melatonin may be useful to control the progression of amyloid pathology in the brain. |
| first_indexed | 2024-03-13T05:38:58Z |
| format | Article |
| id | doaj.art-cae62c84b2d4485bac0a860927e061a9 |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-13T05:38:58Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-cae62c84b2d4485bac0a860927e061a92023-06-14T04:34:38ZengElsevierIBRO Neuroscience Reports2667-24212023-06-0114264272Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease modelMarcos K. Andrade0Leonardo C. Souza1Evellyn M. Azevedo2Ellen L. Bail3Silvio M. Zanata4Roberto Andreatini5Maria A.B.F. Vital6Department of Pharmacology, Federal University of Paraná, PR, BrazilDepartment of Pharmacology, Federal University of Paraná, PR, BrazilDepartment of Physiology, Federal University of Paraná, PR, Brazil; Department of Basic Pathology, Federal University of Paraná, PR, BrazilDepartment of Physiology, Federal University of Paraná, PR, Brazil; Department of Basic Pathology, Federal University of Paraná, PR, BrazilDepartment of Basic Pathology, Federal University of Paraná, PR, BrazilDepartment of Pharmacology, Federal University of Paraná, PR, BrazilDepartment of Pharmacology, Federal University of Paraná, PR, Brazil; Correspondence to: Departamento de Farmacologia, Universidade Federal do Paraná, Centro Politécnico, R. Cel. Francisco H. dos Santos, 100, Jardim das Américas, CEP 80050-540 Curitiba, PR, Brazil.Melatonin is a hormone secreted by the pineal gland, it can be associated with circadian rhythms, aging and neuroprotection. Melatonin levels are decreased in sporadic Alzheimer's disease (sAD) patients, which suggests a relationship between the melatonergic system and sAD. Melatonin may reduce inflammation, oxidative stress, TAU protein hyperphosphorylation, and the formation of β-amyloid (Aβ) aggregates. Therefore, the objective of this work was to investigate the impact of treatment with 10 mg/kg of melatonin (i.p) in the animal model of sAD induced by the intracerebroventricular (ICV) infusion of 3 mg/kg of streptozotocin (STZ). ICV-STZ causes changes in the brain of rats similar to those found in patients with sAD. These changes include; progressive memory decline, the formation of neurofibrillary tangles, senile plaques, disturbances in glucose metabolism, insulin resistance and even reactive astrogliosis characterized by the upregulation of glucose levels and glial fibrillary acidic protein (GFAP). The results show that ICV-STZ caused short-term spatial memory impairment in rats after 30 days of STZ infusion without locomotor impairment which was evaluated on day 27 post-injury. Furthermore, we observed that a prolonged 30-day treatment with melatonin can improve the cognitive impairment of animals in the Y-maze test, but not in the object location test. Finally, we demonstrated that animals receiving ICV-STZ have high levels of Aβ and GFAP in the hippocampus and that treatment with melatonin reduces Aβ levels but does not reduce GFAP levels, concluding that melatonin may be useful to control the progression of amyloid pathology in the brain.http://www.sciencedirect.com/science/article/pii/S2667242123000052Alzheimer's diseaseStreptozotocinMelatoninβ-amyloidGFAPY maze |
| spellingShingle | Marcos K. Andrade Leonardo C. Souza Evellyn M. Azevedo Ellen L. Bail Silvio M. Zanata Roberto Andreatini Maria A.B.F. Vital Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model IBRO Neuroscience Reports Alzheimer's disease Streptozotocin Melatonin β-amyloid GFAP Y maze |
| title | Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model |
| title_full | Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model |
| title_fullStr | Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model |
| title_full_unstemmed | Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model |
| title_short | Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model |
| title_sort | melatonin reduces β amyloid accumulation and improves short term memory in streptozotocin induced sporadic alzheimer s disease model |
| topic | Alzheimer's disease Streptozotocin Melatonin β-amyloid GFAP Y maze |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123000052 |
| work_keys_str_mv | AT marcoskandrade melatoninreducesbamyloidaccumulationandimprovesshorttermmemoryinstreptozotocininducedsporadicalzheimersdiseasemodel AT leonardocsouza melatoninreducesbamyloidaccumulationandimprovesshorttermmemoryinstreptozotocininducedsporadicalzheimersdiseasemodel AT evellynmazevedo melatoninreducesbamyloidaccumulationandimprovesshorttermmemoryinstreptozotocininducedsporadicalzheimersdiseasemodel AT ellenlbail melatoninreducesbamyloidaccumulationandimprovesshorttermmemoryinstreptozotocininducedsporadicalzheimersdiseasemodel AT silviomzanata melatoninreducesbamyloidaccumulationandimprovesshorttermmemoryinstreptozotocininducedsporadicalzheimersdiseasemodel AT robertoandreatini melatoninreducesbamyloidaccumulationandimprovesshorttermmemoryinstreptozotocininducedsporadicalzheimersdiseasemodel AT mariaabfvital melatoninreducesbamyloidaccumulationandimprovesshorttermmemoryinstreptozotocininducedsporadicalzheimersdiseasemodel |