Rifampicin-induced Pancytopenia in Pulmonary Tuberculosis Patient: A Rare Presentation
Tuberculosis (TB) is prevalent throughout the world and is a major public health problem in most developing countries. In India, standardised and Directly Observed Treatment (DOT) under National Tuberculosis Elimination Programme (NTEP) is being recommended currently for drug-sensitive pulmonary TB....
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2024-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/19102/67726_CE[Ra1]_F(IS)_PF1(KB_SS_OM)_PF_NC(KM)_Ref_Pat(OM)_PN(KM).pdf |
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| author | Yashika Bansal Nitin Tangri |
| author_facet | Yashika Bansal Nitin Tangri |
| author_sort | Yashika Bansal |
| collection | DOAJ |
| description | Tuberculosis (TB) is prevalent throughout the world and is a major public health problem in most developing countries. In India, standardised and Directly Observed Treatment (DOT) under National Tuberculosis Elimination Programme (NTEP) is being recommended currently for drug-sensitive pulmonary TB. TB being a major health issue in developing nations like India, causes enormous death and morbidity every year. Anti-Tuberculosis Treatment (ATT) given for TB has been highly effective in fighting the disease and is generally well tolerated, with few minor side-effects. We report a 76-year-old male who was diagnosed with pulmonary TB and was on first-line four-drug anti-tubercular therapy ATT since seven days. He presented to the emergency department with loss of weight and appetite, chest tightness and vomiting. Liver Function Tests (LFT) was deranged, suggesting ATT-induced hepatitis. After normalisation of LFT, rifampicin reintroduction was initiated. Complete Blood Count (CBC) revealed pancytopenia. In bone marrow biopsy, normoblastic maturation with few micronormoblasts and megaloblast picture was seen that did not reveal any granuloma, thereby ruling out the presence of Mycobacterium tuberculosis (MTB). Iron profile and vitamin B12 levels were within normal limits. Rifampicin-induced pancytopenia is rare but its possibility should always be kept in mind while treating with ATT. |
| first_indexed | 2024-03-07T21:37:58Z |
| format | Article |
| id | doaj.art-cae7443355984f7f993dd32e23c24b78 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-07T21:37:58Z |
| publishDate | 2024-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-cae7443355984f7f993dd32e23c24b782024-02-26T11:51:37ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-03-011803010210.7860/JCDR/2024/67726.19102Rifampicin-induced Pancytopenia in Pulmonary Tuberculosis Patient: A Rare PresentationYashika Bansal0Nitin Tangri1Postgraduate Resident, Department of Respiratory Medicine, Adesh Medical College and Hospital, Shahabad (M), Kurukshetra, Haryana, India.Professor, Deptartment of Respiratory Medicine, Adesh Medical College and Hospital, Shahabad (M), Kurukshetra, Haryana, India.Tuberculosis (TB) is prevalent throughout the world and is a major public health problem in most developing countries. In India, standardised and Directly Observed Treatment (DOT) under National Tuberculosis Elimination Programme (NTEP) is being recommended currently for drug-sensitive pulmonary TB. TB being a major health issue in developing nations like India, causes enormous death and morbidity every year. Anti-Tuberculosis Treatment (ATT) given for TB has been highly effective in fighting the disease and is generally well tolerated, with few minor side-effects. We report a 76-year-old male who was diagnosed with pulmonary TB and was on first-line four-drug anti-tubercular therapy ATT since seven days. He presented to the emergency department with loss of weight and appetite, chest tightness and vomiting. Liver Function Tests (LFT) was deranged, suggesting ATT-induced hepatitis. After normalisation of LFT, rifampicin reintroduction was initiated. Complete Blood Count (CBC) revealed pancytopenia. In bone marrow biopsy, normoblastic maturation with few micronormoblasts and megaloblast picture was seen that did not reveal any granuloma, thereby ruling out the presence of Mycobacterium tuberculosis (MTB). Iron profile and vitamin B12 levels were within normal limits. Rifampicin-induced pancytopenia is rare but its possibility should always be kept in mind while treating with ATT.https://www.jcdr.net/articles/PDF/19102/67726_CE[Ra1]_F(IS)_PF1(KB_SS_OM)_PF_NC(KM)_Ref_Pat(OM)_PN(KM).pdfanti-tuberculosis treatmentdirectly observed treatmentdrug-induced reactionmycobacterium tuberculosis |
| spellingShingle | Yashika Bansal Nitin Tangri Rifampicin-induced Pancytopenia in Pulmonary Tuberculosis Patient: A Rare Presentation Journal of Clinical and Diagnostic Research anti-tuberculosis treatment directly observed treatment drug-induced reaction mycobacterium tuberculosis |
| title | Rifampicin-induced Pancytopenia in Pulmonary Tuberculosis Patient: A Rare Presentation |
| title_full | Rifampicin-induced Pancytopenia in Pulmonary Tuberculosis Patient: A Rare Presentation |
| title_fullStr | Rifampicin-induced Pancytopenia in Pulmonary Tuberculosis Patient: A Rare Presentation |
| title_full_unstemmed | Rifampicin-induced Pancytopenia in Pulmonary Tuberculosis Patient: A Rare Presentation |
| title_short | Rifampicin-induced Pancytopenia in Pulmonary Tuberculosis Patient: A Rare Presentation |
| title_sort | rifampicin induced pancytopenia in pulmonary tuberculosis patient a rare presentation |
| topic | anti-tuberculosis treatment directly observed treatment drug-induced reaction mycobacterium tuberculosis |
| url | https://www.jcdr.net/articles/PDF/19102/67726_CE[Ra1]_F(IS)_PF1(KB_SS_OM)_PF_NC(KM)_Ref_Pat(OM)_PN(KM).pdf |
| work_keys_str_mv | AT yashikabansal rifampicininducedpancytopeniainpulmonarytuberculosispatientararepresentation AT nitintangri rifampicininducedpancytopeniainpulmonarytuberculosispatientararepresentation |