Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications
Nanomaterials have been recently introduced as potential diagnostic and therapeutic tools in the medical field. One of the main concerns in relation to the use of nanomaterials in humans is their potential toxicity profile and blood compatibility. In fact, and due to their small size, NPs can transl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcvm.2019.00139/full |
| _version_ | 1818983043299278848 |
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| author | Nadhim Kamil Hante Nadhim Kamil Hante Carlos Medina Maria Jose Santos-Martinez Maria Jose Santos-Martinez |
| author_facet | Nadhim Kamil Hante Nadhim Kamil Hante Carlos Medina Maria Jose Santos-Martinez Maria Jose Santos-Martinez |
| author_sort | Nadhim Kamil Hante |
| collection | DOAJ |
| description | Nanomaterials have been recently introduced as potential diagnostic and therapeutic tools in the medical field. One of the main concerns in relation to the use of nanomaterials in humans is their potential toxicity profile and blood compatibility. In fact, and due to their small size, NPs can translocate into the systemic circulation even after dermal contact, inhalation, or oral ingestion. Once in the blood stream, nanoparticles become in contact with the different components of the blood and can potentially interfere with normal platelet function leading to bleeding or thrombosis. Metallic NPs have been already used for diagnosis and treatment purposes due to their unique characteristics. However, the potential interactions between metallic NPs and platelets has not been widely studied and reported. This review focuses on the factors that can affect platelet activation and aggregation by metal NPs and the nature of such interactions, providing a summary of the effect of various metal NPs on platelet function available in the literature. |
| first_indexed | 2024-12-20T17:56:50Z |
| format | Article |
| id | doaj.art-cae86fd9232d42438074c1050885a9a6 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-20T17:56:50Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-cae86fd9232d42438074c1050885a9a62022-12-21T19:30:44ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2019-09-01610.3389/fcvm.2019.00139478592Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical ApplicationsNadhim Kamil Hante0Nadhim Kamil Hante1Carlos Medina2Maria Jose Santos-Martinez3Maria Jose Santos-Martinez4The School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Dublin, IrelandCollege of Pharmacy, University of Kufa, Najaf, IraqThe School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Dublin, IrelandThe School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Dublin, IrelandSchool of Medicine, Trinity College Dublin, The University of Dublin, Dublin, IrelandNanomaterials have been recently introduced as potential diagnostic and therapeutic tools in the medical field. One of the main concerns in relation to the use of nanomaterials in humans is their potential toxicity profile and blood compatibility. In fact, and due to their small size, NPs can translocate into the systemic circulation even after dermal contact, inhalation, or oral ingestion. Once in the blood stream, nanoparticles become in contact with the different components of the blood and can potentially interfere with normal platelet function leading to bleeding or thrombosis. Metallic NPs have been already used for diagnosis and treatment purposes due to their unique characteristics. However, the potential interactions between metallic NPs and platelets has not been widely studied and reported. This review focuses on the factors that can affect platelet activation and aggregation by metal NPs and the nature of such interactions, providing a summary of the effect of various metal NPs on platelet function available in the literature.https://www.frontiersin.org/article/10.3389/fcvm.2019.00139/fullplateletsmetallic nanoparticlesnanoparticlesactivationaggregationcytotoxicity |
| spellingShingle | Nadhim Kamil Hante Nadhim Kamil Hante Carlos Medina Maria Jose Santos-Martinez Maria Jose Santos-Martinez Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications Frontiers in Cardiovascular Medicine platelets metallic nanoparticles nanoparticles activation aggregation cytotoxicity |
| title | Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications |
| title_full | Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications |
| title_fullStr | Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications |
| title_full_unstemmed | Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications |
| title_short | Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications |
| title_sort | effect on platelet function of metal based nanoparticles developed for medical applications |
| topic | platelets metallic nanoparticles nanoparticles activation aggregation cytotoxicity |
| url | https://www.frontiersin.org/article/10.3389/fcvm.2019.00139/full |
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