What do Cochrane systematic reviews say about the management of irritable bowel syndrome?
ABSTRACT BACKGROUND: Irritable bowel syndrome (IBS) is a clinical disorder associated with high socioeconomic burden. Despite its importance, management of IBS remains difficult and several interventions have been hypothesized as beneficial for this condition. This study identified and summarized...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2019-05-01
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802019000100082&lng=en&tlng=en |
| _version_ | 1819093235645022208 |
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| author | Rafael Leite Pacheco Arnaldo Roizenblatt Aécio Flávio Teixeira de Góis Carolina de Oliveira Cruz Latorraca Carolina Frade Magalhães Girardin Pimentel Mota Rachel Riera |
| author_facet | Rafael Leite Pacheco Arnaldo Roizenblatt Aécio Flávio Teixeira de Góis Carolina de Oliveira Cruz Latorraca Carolina Frade Magalhães Girardin Pimentel Mota Rachel Riera |
| author_sort | Rafael Leite Pacheco |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Irritable bowel syndrome (IBS) is a clinical disorder associated with high socioeconomic burden. Despite its importance, management of IBS remains difficult and several interventions have been hypothesized as beneficial for this condition. This study identified and summarized all Cochrane systematic reviews (SRs) about the effects of interventions for managing IBS patients. DESIGN AND SETTING: Review of systematic reviews, carried out in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP). METHODS: Review of Cochrane SRs addressing interventions for IBS. RESULTS: We included six SRs assessing acupuncture, bulking agents, antispasmodics, antidepressants, herbal medicines, homeopathy, hypnotherapy and psychological therapy for IBS. The certainty of evidence ranged from unknown to moderate, mainly due to imprecision in the estimates and high risk of bias from the primary studies included. There was moderate certainty of evidence that acupuncture had no important benefit regarding improvement of symptoms and quality of life, compared with sham acupuncture. There was also very low certainty of evidence that homeopathic asafoetida, used alone or in association with nux, was better than placebo regarding self-reported overall improvement. CONCLUSION: There was moderate certainty of evidence that acupuncture had no important benefit regarding improvement of symptoms and quality of life. Further well-designed and well-conducted randomized clinical trials are needed in order to reduce the uncertainties regarding the most commonly used interventions for patients with IBS. |
| first_indexed | 2024-12-21T23:08:17Z |
| format | Article |
| id | doaj.art-cae88fda373e4d2e81e8d496ac0c9f00 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-21T23:08:17Z |
| publishDate | 2019-05-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-cae88fda373e4d2e81e8d496ac0c9f002022-12-21T18:47:06ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602019-05-011371829110.1590/1516-3180.2018.053740119S1516-31802019000100082What do Cochrane systematic reviews say about the management of irritable bowel syndrome?Rafael Leite PachecoArnaldo RoizenblattAécio Flávio Teixeira de GóisCarolina de Oliveira Cruz LatorracaCarolina Frade Magalhães Girardin Pimentel MotaRachel RieraABSTRACT BACKGROUND: Irritable bowel syndrome (IBS) is a clinical disorder associated with high socioeconomic burden. Despite its importance, management of IBS remains difficult and several interventions have been hypothesized as beneficial for this condition. This study identified and summarized all Cochrane systematic reviews (SRs) about the effects of interventions for managing IBS patients. DESIGN AND SETTING: Review of systematic reviews, carried out in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP). METHODS: Review of Cochrane SRs addressing interventions for IBS. RESULTS: We included six SRs assessing acupuncture, bulking agents, antispasmodics, antidepressants, herbal medicines, homeopathy, hypnotherapy and psychological therapy for IBS. The certainty of evidence ranged from unknown to moderate, mainly due to imprecision in the estimates and high risk of bias from the primary studies included. There was moderate certainty of evidence that acupuncture had no important benefit regarding improvement of symptoms and quality of life, compared with sham acupuncture. There was also very low certainty of evidence that homeopathic asafoetida, used alone or in association with nux, was better than placebo regarding self-reported overall improvement. CONCLUSION: There was moderate certainty of evidence that acupuncture had no important benefit regarding improvement of symptoms and quality of life. Further well-designed and well-conducted randomized clinical trials are needed in order to reduce the uncertainties regarding the most commonly used interventions for patients with IBS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802019000100082&lng=en&tlng=enReview [publication type]Irritable bowel syndromeColonic diseases, functionalEvidence-based medicineEvidence-based practice |
| spellingShingle | Rafael Leite Pacheco Arnaldo Roizenblatt Aécio Flávio Teixeira de Góis Carolina de Oliveira Cruz Latorraca Carolina Frade Magalhães Girardin Pimentel Mota Rachel Riera What do Cochrane systematic reviews say about the management of irritable bowel syndrome? São Paulo Medical Journal Review [publication type] Irritable bowel syndrome Colonic diseases, functional Evidence-based medicine Evidence-based practice |
| title | What do Cochrane systematic reviews say about the management of irritable bowel syndrome? |
| title_full | What do Cochrane systematic reviews say about the management of irritable bowel syndrome? |
| title_fullStr | What do Cochrane systematic reviews say about the management of irritable bowel syndrome? |
| title_full_unstemmed | What do Cochrane systematic reviews say about the management of irritable bowel syndrome? |
| title_short | What do Cochrane systematic reviews say about the management of irritable bowel syndrome? |
| title_sort | what do cochrane systematic reviews say about the management of irritable bowel syndrome |
| topic | Review [publication type] Irritable bowel syndrome Colonic diseases, functional Evidence-based medicine Evidence-based practice |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802019000100082&lng=en&tlng=en |
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