B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphoma
Secondary acute lymphoblastic leukemia (ALL) is a rare disease that has not been well characterized compared with secondary myelodysplastic syndrome or secondary acute myeloid leukemia. We present a report of two patients who developed ALL following complete remission of diffuse large B-cell lymphom...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | https://www.pagepress.org/journals/index.php/hr/article/view/8100 |
| _version_ | 1828045918353489920 |
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| author | Daria Gaut Anthony Bejjani Joshua Sasine Gary Schiller |
| author_facet | Daria Gaut Anthony Bejjani Joshua Sasine Gary Schiller |
| author_sort | Daria Gaut |
| collection | DOAJ |
| description | Secondary acute lymphoblastic leukemia (ALL) is a rare disease that has not been well characterized compared with secondary myelodysplastic syndrome or secondary acute myeloid leukemia. We present a report of two patients who developed ALL following complete remission of diffuse large B-cell lymphoma (DLBCL). The first case is more consistent with a therapy-related ALL as a PCR analysis of bone marrow aspirate revealed a distinct clone and the mixed-lineage leukemia gene rearrangement, commonly associated with exposure to topoisomerase II inhibitors. The second case is more consistent with clonal evolution given positive MYC and BCL2 fusion signals in the original diagnosis of DLBCL and the secondary ALL. |
| first_indexed | 2024-04-10T18:18:23Z |
| format | Article |
| id | doaj.art-cae9b2965ada453c855b1ba6a8aa7f2b |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:18:23Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-cae9b2965ada453c855b1ba6a8aa7f2b2023-02-02T08:03:17ZengMDPI AGHematology Reports2038-83222038-83302019-06-0111210.4081/hr.2019.8100B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphomaDaria Gaut0Anthony Bejjani1Joshua Sasine2Gary Schiller3Department of Medicine, University of California Los Angeles, CADivision of Hematology/Oncology, David Geffen School of Medicine, University of California Los Angeles, CADivision of Hematology/Oncology, David Geffen School of Medicine, University of California Los Angeles, CADivision of Hematology/Oncology, David Geffen School of Medicine, University of California Los Angeles, CASecondary acute lymphoblastic leukemia (ALL) is a rare disease that has not been well characterized compared with secondary myelodysplastic syndrome or secondary acute myeloid leukemia. We present a report of two patients who developed ALL following complete remission of diffuse large B-cell lymphoma (DLBCL). The first case is more consistent with a therapy-related ALL as a PCR analysis of bone marrow aspirate revealed a distinct clone and the mixed-lineage leukemia gene rearrangement, commonly associated with exposure to topoisomerase II inhibitors. The second case is more consistent with clonal evolution given positive MYC and BCL2 fusion signals in the original diagnosis of DLBCL and the secondary ALL.https://www.pagepress.org/journals/index.php/hr/article/view/8100acute lymphoblastic leukemiadiffuse large B-cell lymphoma, secondary malignancysecondary acute lymphoblastic leukemiatherapy-related acute lymphoblastic leukemia |
| spellingShingle | Daria Gaut Anthony Bejjani Joshua Sasine Gary Schiller B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphoma Hematology Reports acute lymphoblastic leukemia diffuse large B-cell lymphoma, secondary malignancy secondary acute lymphoblastic leukemia therapy-related acute lymphoblastic leukemia |
| title | B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphoma |
| title_full | B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphoma |
| title_fullStr | B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphoma |
| title_full_unstemmed | B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphoma |
| title_short | B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphoma |
| title_sort | b cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large b cell lymphoma |
| topic | acute lymphoblastic leukemia diffuse large B-cell lymphoma, secondary malignancy secondary acute lymphoblastic leukemia therapy-related acute lymphoblastic leukemia |
| url | https://www.pagepress.org/journals/index.php/hr/article/view/8100 |
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