An ETV6-ABL1 fusion in a patient with chronic myeloproliferative neoplasm: Initial response to Imatinib followed by rapid transformation into ALL

An ETV6-ABL1 fusion in a patient with chronic myeloproliferative neoplasm: Initial response to Imatinib followed by rapid transformation into ALL

We report the case of a 26 year-old patient presenting with a persistent leukocytosis and CML-like marrow but no evidence of a BCR/ABL1 fusion. Molecular cytogenetics revealed that a portion of the ETV6 locus was inserted into the ABL1 locus. An ETV6/ABL1 fusion transcript could subsequently be conf...

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Bibliographic Details
Main Authors: Purvi M. Kakadia, Ralf Schmidmaier, Andreas Völkl, Irene Schneider, Natalia Huk, Stephanie Schneider, Gerda Panzner, Ulrike Neidel, Barbara Fritz, Karsten Spiekermann, Stefan K. Bohlander
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Leukemia Research Reports
Subjects:
ETV6/ABL1 fusion
CML
ALL
MRD assay
TKI treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048916300206

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